EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3)

2003-05-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
PEK,PERK,WRS
FUSION GENES

Other Information

Locus ID:

NCBI: 9451
MIM: 604032
HGNC: 3255
Ensembl: ENSG00000172071

Variants:

dbSNP: 9451
ClinVar: 9451
TCGA: ENSG00000172071
COSMIC: EIF2AK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172071ENST00000303236Q9NZJ5
ENSG00000172071ENST00000652099A0A494BZR8
ENSG00000172071ENST00000652423A0A494C186

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
ApoptosisKEGGko04210
Alzheimer's diseaseKEGGko05010
Autophagy - animalKEGGhsa04140
ApoptosisKEGGhsa04210
Alzheimer's diseaseKEGGhsa05010
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161489482005ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.240
123702882002Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.225
120149892002Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.164
221694772011H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.144
231100432012ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK.100
229175052012Unfolded protein response.91
272118002016The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.91
217090202011PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.90
187874112008Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40424/eif2ak3