EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

Identity

Other names	GCN2
	KIAA1338
HGNC	EIF2AK4
Location	15q15.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	EIF2AK4   19687
Entrez_Gene	EIF2AK4  440275  eukaryotic translation initiation factor 2 alpha kinase 4
	Cards
GeneCards	EIF2AK4
Ensembl	EIF2AK4 [Search_View]   ENSG00000128829 [Gene_View]
Genatlas	EIF2AK4
GeneLynx	EIF2AK4
eGenome	EIF2AK4
euGene	440275
	Genomic and cartography
GoldenPath	EIF2AK4  -  15q15.1   chr15:38013639-38115089 +  15q15.1   [Description]    (hg18-March_2006)
Ensembl	EIF2AK4 - 15q15.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EIF2AK4
	Gene and transcription
Genbank	AB037759 [ ENTREZ ]
Genbank	AJ243428 [ ENTREZ ]
Genbank	AK027011 [ ENTREZ ]
Genbank	AK074361 [ ENTREZ ]
Genbank	AL137627 [ ENTREZ ]
RefSeq	NM_001013703 [ SRS ]    NM_001013703 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	AC_000147 [ SRS ]    AC_000147 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_001838214 [ SRS ]    NW_001838214 [ ENTREZ ]
RefSeq	NW_925840 [ SRS ]    NW_925840 [ ENTREZ ]
AceView	EIF2AK4 AceView - NCBI
Unigene	Hs.656673 [ SRS ]    Hs.656673 [ NCBI ]     HS656673 [ spliceNest ]
Fast-db	2009 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9P2K8 [ SRS]    Q9P2K8 [ EXPASY ]     Q9P2K8 [ INTERPRO ]     Q9P2K8 [ UNIPROT ]
Prosite	PS50862 AA_TRNA_LIGASE_II [ SRS ]    PS50862 AA_TRNA_LIGASE_II [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS50908 RWD [ SRS ]    PS50908 RWD [ Expasy ]
Interpro	IPR002314 aa-tRNA-synt_IIb [ SRS ]    IPR002314 aa-tRNA-synt_IIb [ EBI ]
Interpro	IPR006195 aa-tRNA-synth_II [ SRS ]    IPR006195 aa-tRNA-synth_II [ EBI ]
Interpro	IPR015515 GCN2 [ SRS ]    IPR015515 GCN2 [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR006575 RWD [ SRS ]    IPR006575 RWD [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR016255 Ser/Thr_prot_kinase_GCN2 [ SRS ]    IPR016255 Ser/Thr_prot_kinase_GCN2 [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR016135 UBQ-conjugat/RWD-like [ SRS ]    IPR016135 UBQ-conjugat/RWD-like [ EBI ]
CluSTr	Q9P2K8
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF05773 RWD [ SRS ]    PF05773 RWD [ Sanger ]    pfam05773 [ NCBI-CDD ]
Pfam	PF00587 tRNA-synt_2b [ SRS ]    PF00587 tRNA-synt_2b [ Sanger ]    pfam00587 [ NCBI-CDD ]
Smart	SM00591 RWD [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q9P2K8 E2AK4_HUMAN [ Domain structure ]   Q9P2K8 E2AK4_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q9P2K8
HPRD	18447
	Protein Interaction databases
DIP	Q9P2K8
IntAct	Q9P2K8
	Polymorphism : SNP, mutations, diseases
OMIM	609280    [ map ]
GENECLINICS	609280
SNP	EIF2AK4 [dbSNP-NCBI]
SNP	NM_001013703 [SNP-NCI]
SNP	EIF2AK4 [GeneSNPs - Utah]  EIF2AK4] [HGBASE - SRS]
HAPMAP	EIF2AK4 [HAPMAP]
COSMIC	EIF2AK4 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	EIF2AK4
	General knowledge
Family Browser	EIF2AK4 [UCSC Family Browser]
SOURCE	NM_001013703
SMD	Hs.656673
SAGE	Hs.656673
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	eukaryotic translation initiation factor 2alpha kinase activity [Amigo]  eukaryotic translation initiation factor 2alpha kinase activity
GO	aminoacyl-tRNA ligase activity [Amigo]  aminoacyl-tRNA ligase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	tRNA aminoacylation for protein translation [Amigo]  tRNA aminoacylation for protein translation
GO	regulation of translational initiation [Amigo]  regulation of translational initiation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transferase activity [Amigo]  transferase activity
GO	cytosolic ribosome [Amigo]  cytosolic ribosome
BIOCARTA	Regulation of eIF2    [Genes]
PubGene	EIF2AK4
TreeFam	EIF2AK4
CTD	440275 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EIF2AK4 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:09:17 2008