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EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)

Identity

Alias_namesEIF2B
eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kD)
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Alias_symbol (synonym)EIF-2Balpha
EIF-2B
EIF2BA
Other alias
HGNC (Hugo) EIF2B1
LocusID (NCBI) 1967
Atlas_Id 62773
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 123621023 and ends at 123633776 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2B1   3257
Cards
Entrez_Gene (NCBI)EIF2B1  1967  eukaryotic translation initiation factor 2B subunit alpha
AliasesEIF2B; EIF2BA
GeneCards (Weizmann)EIF2B1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr12:123621023-123633776 [Contig_View]  EIF2B1 [Vega]
TCGA cBioPortalEIF2B1
AceView (NCBI)EIF2B1
Genatlas (Paris)EIF2B1
WikiGenes1967
SOURCE (Princeton)EIF2B1
Genetics Home Reference (NIH)EIF2B1
Genomic and cartography
GoldenPath hg38 (UCSC)EIF2B1  -     chr12:123621023-123633776 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF2B1  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblEIF2B1 - 12q24.31 [CytoView hg19]  EIF2B1 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIEIF2B1 [Mapview hg19]  EIF2B1 [Mapview hg38]
OMIM603896   606686   
Gene and transcription
Genbank (Entrez)AI540796 AK294815 AL541292 BC103763 BC104188
RefSeq transcript (Entrez)NM_001414
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF2B1
Cluster EST : UnigeneHs.741273 [ NCBI ]
CGAP (NCI)Hs.741273
Gene ExpressionEIF2B1 [ NCBI-GEO ]   EIF2B1 [ EBI - ARRAY_EXPRESS ]   EIF2B1 [ SEEK ]   EIF2B1 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1967
GTEX Portal (Tissue expression)EIF2B1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14232
Splice isoforms : SwissVarQ14232
PhosPhoSitePlusQ14232
Domains : Interpro (EBI)IF-2B-related   
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
Conserved Domain (NCBI)EIF2B1
DMDM Disease mutations1967
Blocks (Seattle)EIF2B1
PDB (SRS)3ECS   
PDB (PDBSum)3ECS   
PDB (IMB)3ECS   
PDB (RSDB)3ECS   
Structural Biology KnowledgeBase3ECS   
SCOP (Structural Classification of Proteins)3ECS   
CATH (Classification of proteins structures)3ECS   
SuperfamilyQ14232
Peptide AtlasQ14232
HPRD09458
IPIIPI00221300   IPI01015264   IPI01013010   IPI01014305   IPI00910969   
Protein Interaction databases
DIP (DOE-UCLA)Q14232
IntAct (EBI)Q14232
BioGRIDEIF2B1
STRING (EMBL)EIF2B1
ZODIACEIF2B1
Ontologies - Pathways
QuickGOQ14232
Ontology : AmiGOtranslation initiation factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  plasma membrane  translational initiation  response to heat  response to heat  response to glucose  oligodendrocyte development  membrane  identical protein binding  response to peptide hormone  positive regulation of GTPase activity  cellular response to stimulus  
Ontology : EGO-EBItranslation initiation factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  plasma membrane  translational initiation  response to heat  response to heat  response to glucose  oligodendrocyte development  membrane  identical protein binding  response to peptide hormone  positive regulation of GTPase activity  cellular response to stimulus  
Pathways : BIOCARTAVEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkEIF2B1
Atlas of Cancer Signalling NetworkEIF2B1
Wikipedia pathwaysEIF2B1
Orthology - Evolution
OrthoDB1967
Phylogenetic Trees/Animal Genes : TreeFamEIF2B1
HOVERGENQ14232
HOGENOMQ14232
Homologs : HomoloGeneEIF2B1
Homology/Alignments : Family Browser (UCSC)EIF2B1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2B1
dbVarEIF2B1
ClinVarEIF2B1
1000_GenomesEIF2B1 
Exome Variant ServerEIF2B1
ExAC (Exome Aggregation Consortium)EIF2B1 (select the gene name)
Genetic variants : HAPMAP1967
Genomic Variants (DGV)EIF2B1 [DGVbeta]
DECIPHEREIF2B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF2B1 
Mutations
ICGC Data PortalEIF2B1 
TCGA Data PortalEIF2B1 
Broad Tumor PortalEIF2B1
OASIS PortalEIF2B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF2B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch EIF2B1
DgiDB (Drug Gene Interaction Database)EIF2B1
DoCM (Curated mutations)EIF2B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2B1 (select a term)
intoGenEIF2B1
Cancer3DEIF2B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603896    606686   
Orphanet17140    17141    17139    14426    14427   
MedgenEIF2B1
Genetic Testing Registry EIF2B1
NextProtQ14232 [Medical]
TSGene1967
GENETestsEIF2B1
Target ValidationEIF2B1
Huge Navigator EIF2B1 [HugePedia]
snp3D : Map Gene to Disease1967
BioCentury BCIQEIF2B1
ClinGenEIF2B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1967
Chemical/Pharm GKB GenePA27688
Clinical trialEIF2B1
Miscellaneous
canSAR (ICR)EIF2B1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2B1
EVEXEIF2B1
GoPubMedEIF2B1
iHOPEIF2B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:06:57 CEST 2017

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