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EIF2B2 (eukaryotic translation initiation factor 2B subunit beta)

Identity

Alias_nameseukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD)
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Alias_symbol (synonym)EIF2B
EIF-2Bbeta
Other alias
HGNC (Hugo) EIF2B2
LocusID (NCBI) 8892
Atlas_Id 62774
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 75002909 and ends at 75009591 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF2B2 (14q24.3) / EIF2B2 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2B2   3258
Cards
Entrez_Gene (NCBI)EIF2B2  8892  eukaryotic translation initiation factor 2B subunit beta
AliasesEIF-2Bbeta; EIF2B
GeneCards (Weizmann)EIF2B2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr14:75002909-75009591 [Contig_View]  EIF2B2 [Vega]
TCGA cBioPortalEIF2B2
AceView (NCBI)EIF2B2
Genatlas (Paris)EIF2B2
WikiGenes8892
SOURCE (Princeton)EIF2B2
Genetics Home Reference (NIH)EIF2B2
Genomic and cartography
GoldenPath hg38 (UCSC)EIF2B2  -     chr14:75002909-75009591 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF2B2  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblEIF2B2 - 14q24.3 [CytoView hg19]  EIF2B2 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIEIF2B2 [Mapview hg19]  EIF2B2 [Mapview hg38]
OMIM603896   606454   
Gene and transcription
Genbank (Entrez)AF035280 AI265790 BC000494 BC003165 BC011750
RefSeq transcript (Entrez)NM_014239
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF2B2
Cluster EST : UnigeneHs.409137 [ NCBI ]
CGAP (NCI)Hs.409137
Gene ExpressionEIF2B2 [ NCBI-GEO ]   EIF2B2 [ EBI - ARRAY_EXPRESS ]   EIF2B2 [ SEEK ]   EIF2B2 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8892
GTEX Portal (Tissue expression)EIF2B2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49770   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49770  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49770
Splice isoforms : SwissVarP49770
PhosPhoSitePlusP49770
Domains : Interpro (EBI)IF-2B-related   
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
Conserved Domain (NCBI)EIF2B2
DMDM Disease mutations8892
Blocks (Seattle)EIF2B2
SuperfamilyP49770
Peptide AtlasP49770
HPRD05923
IPIIPI00028083   IPI01025442   IPI01025566   IPI01025248   
Protein Interaction databases
DIP (DOE-UCLA)P49770
IntAct (EBI)P49770
BioGRIDEIF2B2
STRING (EMBL)EIF2B2
ZODIACEIF2B2
Ontologies - Pathways
QuickGOP49770
Ontology : AmiGOovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  ATP binding  GTP binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translational initiation  central nervous system development  response to heat  response to heat  response to glucose  oligodendrocyte development  myelination  response to peptide hormone  positive regulation of GTPase activity  cellular response to stimulus  
Ontology : EGO-EBIovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  ATP binding  GTP binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translational initiation  central nervous system development  response to heat  response to heat  response to glucose  oligodendrocyte development  myelination  response to peptide hormone  positive regulation of GTPase activity  cellular response to stimulus  
Pathways : BIOCARTAVEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkEIF2B2
Atlas of Cancer Signalling NetworkEIF2B2
Wikipedia pathwaysEIF2B2
Orthology - Evolution
OrthoDB8892
Phylogenetic Trees/Animal Genes : TreeFamEIF2B2
HOVERGENP49770
HOGENOMP49770
Homologs : HomoloGeneEIF2B2
Homology/Alignments : Family Browser (UCSC)EIF2B2
Gene fusions - Rearrangements
Fusion: Tumor Portal EIF2B2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2B2
dbVarEIF2B2
ClinVarEIF2B2
1000_GenomesEIF2B2 
Exome Variant ServerEIF2B2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP8892
Genomic Variants (DGV)EIF2B2 [DGVbeta]
DECIPHEREIF2B2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF2B2 
Mutations
ICGC Data PortalEIF2B2 
TCGA Data PortalEIF2B2 
Broad Tumor PortalEIF2B2
OASIS PortalEIF2B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF2B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch EIF2B2
DgiDB (Drug Gene Interaction Database)EIF2B2
DoCM (Curated mutations)EIF2B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2B2 (select a term)
intoGenEIF2B2
Cancer3DEIF2B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603896    606454   
Orphanet17140    17141    17139    14426    14427   
MedgenEIF2B2
Genetic Testing Registry EIF2B2
NextProtP49770 [Medical]
TSGene8892
GENETestsEIF2B2
Target ValidationEIF2B2
Huge Navigator EIF2B2 [HugePedia]
snp3D : Map Gene to Disease8892
BioCentury BCIQEIF2B2
ClinGenEIF2B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8892
Chemical/Pharm GKB GenePA27689
Clinical trialEIF2B2
Miscellaneous
canSAR (ICR)EIF2B2 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2B2
EVEXEIF2B2
GoPubMedEIF2B2
iHOPEIF2B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:45:35 CET 2017

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