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EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)

Identity

Alias (NCBI)EIF-2B
EIF2B
EIF2Bdelta
HGNC (Hugo) EIF2B4
HGNC Alias symbEIF2Bdelta
EIF-2B
DKFZP586J0119
EIF2B
HGNC Previous nameeukaryotic translation initiation factor 2B, subunit 4 (delta, 67kD)
 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
LocusID (NCBI) 8890
Atlas_Id 51837
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27364352 and ends at 27370052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CALR (19p13.2) / EIF2B4 (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)EIF2B4   3260
Cards
Entrez_Gene (NCBI)EIF2B4  8890  eukaryotic translation initiation factor 2B subunit delta
AliasesEIF-2B; EIF2B; EIF2Bdelta
GeneCards (Weizmann)EIF2B4
Ensembl hg19 (Hinxton)ENSG00000115211 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115211 [Gene_View]  ENSG00000115211 [Sequence]  chr2:27364352-27370052 [Contig_View]  EIF2B4 [Vega]
ICGC DataPortalENSG00000115211
TCGA cBioPortalEIF2B4
AceView (NCBI)EIF2B4
Genatlas (Paris)EIF2B4
WikiGenes8890
SOURCE (Princeton)EIF2B4
Genetics Home Reference (NIH)EIF2B4
Genomic and cartography
GoldenPath hg38 (UCSC)EIF2B4  -     chr2:27364352-27370052 -  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF2B4  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathEIF2B4 - 2p23.3 [CytoView hg19]  EIF2B4 - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000115211
genome Data Viewer NCBIEIF2B4 [Mapview hg19]  
OMIM603896   606687   
Gene and transcription
Genbank (Entrez)AB209532 AF057699 AF086520 AF112207 AF218009
RefSeq transcript (Entrez)NM_001034116 NM_001318965 NM_001318966 NM_001318967 NM_001318968 NM_001318969 NM_015636 NM_172195
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF2B4
Alternative Splicing GalleryENSG00000115211
Gene ExpressionEIF2B4 [ NCBI-GEO ]   EIF2B4 [ EBI - ARRAY_EXPRESS ]   EIF2B4 [ SEEK ]   EIF2B4 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2B4 [ Firebrowse - Broad ]
GenevisibleExpression of EIF2B4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8890
GTEX Portal (Tissue expression)EIF2B4
Human Protein AtlasENSG00000115211-EIF2B4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI10   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI10  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI10
Splice isoforms : SwissVarQ9UI10
PhosPhoSitePlusQ9UI10
Domains : Interpro (EBI)IF-2B-related    IF_2B-like_C    NagB/RpiA_transferase-like   
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
Conserved Domain (NCBI)EIF2B4
DMDM Disease mutations8890
Blocks (Seattle)EIF2B4
PDB (RSDB)6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
PDB Europe6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
PDB (PDBSum)6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
PDB (IMB)6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
Structural Biology KnowledgeBase6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
SCOP (Structural Classification of Proteins)6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
CATH (Classification of proteins structures)6CAJ    6EZO    6K71    6K72    6O81    6O85    6O9Z   
SuperfamilyQ9UI10
Human Protein Atlas [tissue]ENSG00000115211-EIF2B4 [tissue]
Peptide AtlasQ9UI10
HPRD09459
IPIIPI00005979   IPI00220232   IPI00654843   IPI00908922   IPI01011751   IPI00556659   IPI00893055   IPI00893169   IPI00892585   IPI00983659   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI10
IntAct (EBI)Q9UI10
FunCoupENSG00000115211
BioGRIDEIF2B4
STRING (EMBL)EIF2B4
ZODIACEIF2B4
Ontologies - Pathways
QuickGOQ9UI10
Ontology : AmiGOovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translation  response to heat  response to heat  response to glucose  oligodendrocyte development  translation initiation factor binding  myelination  response to peptide hormone  T cell receptor signaling pathway  
Ontology : EGO-EBIovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translation  response to heat  response to heat  response to glucose  oligodendrocyte development  translation initiation factor binding  myelination  response to peptide hormone  T cell receptor signaling pathway  
Pathways : KEGGRNA transport   
NDEx NetworkEIF2B4
Atlas of Cancer Signalling NetworkEIF2B4
Wikipedia pathwaysEIF2B4
Orthology - Evolution
OrthoDB8890
GeneTree (enSembl)ENSG00000115211
Phylogenetic Trees/Animal Genes : TreeFamEIF2B4
HOGENOMQ9UI10
Homologs : HomoloGeneEIF2B4
Homology/Alignments : Family Browser (UCSC)EIF2B4
Gene fusions - Rearrangements
Fusion : QuiverEIF2B4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2B4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2B4
dbVarEIF2B4
ClinVarEIF2B4
MonarchEIF2B4
1000_GenomesEIF2B4 
Exome Variant ServerEIF2B4
GNOMAD BrowserENSG00000115211
Varsome BrowserEIF2B4
Genetic variants : HAPMAP8890
Genomic Variants (DGV)EIF2B4 [DGVbeta]
DECIPHEREIF2B4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF2B4 
Mutations
ICGC Data PortalEIF2B4 
TCGA Data PortalEIF2B4 
Broad Tumor PortalEIF2B4
OASIS PortalEIF2B4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2B4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF2B4
Mutations and Diseases : HGMDEIF2B4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch EIF2B4
DgiDB (Drug Gene Interaction Database)EIF2B4
DoCM (Curated mutations)EIF2B4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2B4 (select a term)
intoGenEIF2B4
Cancer3DEIF2B4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603896    606687   
Orphanet17140    17141    17139    14426    14427   
DisGeNETEIF2B4
MedgenEIF2B4
Genetic Testing Registry EIF2B4
NextProtQ9UI10 [Medical]
TSGene8890
GENETestsEIF2B4
Target ValidationEIF2B4
Huge Navigator EIF2B4 [HugePedia]
snp3D : Map Gene to Disease8890
BioCentury BCIQEIF2B4
ClinGenEIF2B4
Clinical trials, drugs, therapy
Protein Interactions : CTD8890
Pharm GKB GenePA27691
Clinical trialEIF2B4
Miscellaneous
canSAR (ICR)EIF2B4 (select the gene name)
HarmonizomeEIF2B4
DataMed IndexEIF2B4
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2B4
EVEXEIF2B4
GoPubMedEIF2B4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:09:52 CEST 2020

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