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EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)

Identity

Other namesEIF-2B
EIF2B
EIF2Bdelta
HGNC (Hugo) EIF2B4
LocusID (NCBI) 8890
Atlas_Id 51837
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27587219 and ends at 27593324 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CALR (19p13.2) / EIF2B4 (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2B4   3260
Cards
Entrez_Gene (NCBI)EIF2B4  8890  eukaryotic translation initiation factor 2B subunit delta
AliasesEIF-2B; EIF2B; EIF2Bdelta
GeneCards (Weizmann)EIF2B4
Ensembl hg19 (Hinxton)ENSG00000115211 [Gene_View]  chr2:27587219-27593324 [Contig_View]  EIF2B4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115211 [Gene_View]  chr2:27587219-27593324 [Contig_View]  EIF2B4 [Vega]
ICGC DataPortalENSG00000115211
TCGA cBioPortalEIF2B4
AceView (NCBI)EIF2B4
Genatlas (Paris)EIF2B4
WikiGenes8890
SOURCE (Princeton)EIF2B4
Genomic and cartography
GoldenPath hg19 (UCSC)EIF2B4  -     chr2:27587219-27593324 -  2p23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF2B4  -     2p23.3   [Description]    (hg38-Dec_2013)
EnsemblEIF2B4 - 2p23.3 [CytoView hg19]  EIF2B4 - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIEIF2B4 [Mapview hg19]  EIF2B4 [Mapview hg38]
OMIM603896   606687   
Gene and transcription
Genbank (Entrez)AB209532 AF057699 AF086520 AF112207 AF218009
RefSeq transcript (Entrez)NM_001034116 NM_001318965 NM_001318966 NM_001318967 NM_001318968 NM_001318969 NM_015636 NM_172195
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_009305 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)EIF2B4
Cluster EST : UnigeneHs.169474 [ NCBI ]
CGAP (NCI)Hs.169474
Alternative Splicing GalleryENSG00000115211
Gene ExpressionEIF2B4 [ NCBI-GEO ]   EIF2B4 [ EBI - ARRAY_EXPRESS ]   EIF2B4 [ SEEK ]   EIF2B4 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2B4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8890
GTEX Portal (Tissue expression)EIF2B4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI10 (Uniprot)
NextProtQ9UI10  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI10
Splice isoforms : SwissVarQ9UI10 (Swissvar)
PhosPhoSitePlusQ9UI10
Domains : Interpro (EBI)IF-2B-related   
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
DMDM Disease mutations8890
Blocks (Seattle)EIF2B4
SuperfamilyQ9UI10
Human Protein AtlasENSG00000115211
Peptide AtlasQ9UI10
HPRD09459
IPIIPI00005979   IPI00220232   IPI00654843   IPI00908922   IPI01011751   IPI00556659   IPI00893055   IPI00893169   IPI00892585   IPI00983659   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI10
IntAct (EBI)Q9UI10
FunCoupENSG00000115211
BioGRIDEIF2B4
STRING (EMBL)EIF2B4
ZODIACEIF2B4
Ontologies - Pathways
QuickGOQ9UI10
Ontology : AmiGOovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translation  response to heat  response to heat  response to glucose  oligodendrocyte development  L-methionine biosynthetic process from methylthioadenosine  translation initiation factor binding  negative regulation of translational initiation in response to stress  myelination  response to peptide hormone  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of translational initiation  S-methyl-5-thioribose-1-phosphate isomerase activity  cellular response to stimulus  
Ontology : EGO-EBIovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translational initiation  regulation of translation  response to heat  response to heat  response to glucose  oligodendrocyte development  L-methionine biosynthetic process from methylthioadenosine  translation initiation factor binding  negative regulation of translational initiation in response to stress  myelination  response to peptide hormone  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of translational initiation  S-methyl-5-thioribose-1-phosphate isomerase activity  cellular response to stimulus  
Pathways : BIOCARTAVEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGRNA transport   
NDEx Network
Atlas of Cancer Signalling NetworkEIF2B4
Wikipedia pathwaysEIF2B4
Orthology - Evolution
OrthoDB8890
GeneTree (enSembl)ENSG00000115211
Phylogenetic Trees/Animal Genes : TreeFamEIF2B4
Homologs : HomoloGeneEIF2B4
Homology/Alignments : Family Browser (UCSC)EIF2B4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerEIF2B4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2B4
dbVarEIF2B4
ClinVarEIF2B4
1000_GenomesEIF2B4 
Exome Variant ServerEIF2B4
ExAC (Exome Aggregation Consortium)EIF2B4 (select the gene name)
Genetic variants : HAPMAP8890
Genomic Variants (DGV)EIF2B4 [DGVbeta]
Mutations
ICGC Data PortalEIF2B4 
TCGA Data PortalEIF2B4 
Broad Tumor PortalEIF2B4
OASIS PortalEIF2B4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2B4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch EIF2B4
DgiDB (Drug Gene Interaction Database)EIF2B4
DoCM (Curated mutations)EIF2B4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2B4 (select a term)
intoGenEIF2B4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:27587219-27593324  ENSG00000115211
CONAN: Copy Number AnalysisEIF2B4 
Mutations and Diseases : HGMDEIF2B4
OMIM603896    606687   
MedgenEIF2B4
Genetic Testing Registry EIF2B4
NextProtQ9UI10 [Medical]
TSGene8890
GENETestsEIF2B4
Huge Navigator EIF2B4 [HugePedia]
snp3D : Map Gene to Disease8890
BioCentury BCIQEIF2B4
ClinGenEIF2B4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8890
Chemical/Pharm GKB GenePA27691
Clinical trialEIF2B4
Miscellaneous
canSAR (ICR)EIF2B4 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2B4
EVEXEIF2B4
GoPubMedEIF2B4
iHOPEIF2B4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:13:10 CEST 2016

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