Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EIF2B4 (eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa)

Identity

Other namesEIF-2B
EIF2B
EIF2Bdelta
HGNC (Hugo) EIF2B4
LocusID (NCBI) 8890
Location 2p23.3
Location_base_pair Starts at 27587219 and ends at 27593324 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)EIF2B4   3260
Cards
Entrez_Gene (NCBI)EIF2B4  8890  eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
GeneCards (Weizmann)EIF2B4
Ensembl (Hinxton)ENSG00000115211 [Gene_View]  chr2:27587219-27593324 [Contig_View]  EIF2B4 [Vega]
ICGC DataPortalENSG00000115211
cBioPortalEIF2B4
AceView (NCBI)EIF2B4
Genatlas (Paris)EIF2B4
WikiGenes8890
SOURCE (Princeton)NM_001034116 NM_015636 NM_172195
Genomic and cartography
GoldenPath (UCSC)EIF2B4  -  2p23.3   chr2:27587219-27593324 -  2p23.3   [Description]    (hg19-Feb_2009)
EnsemblEIF2B4 - 2p23.3 [CytoView]
Mapping of homologs : NCBIEIF2B4 [Mapview]
OMIM603896   606687   
Gene and transcription
Genbank (Entrez)AB209532 AF057699 AF086520 AF112207 AF218009
RefSeq transcript (Entrez)NM_001034116 NM_015636 NM_172195
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_009305 NT_022184 NW_001838768 NW_004929300
Consensus coding sequences : CCDS (NCBI)EIF2B4
Cluster EST : UnigeneHs.169474 [ NCBI ]
CGAP (NCI)Hs.169474
Alternative Splicing : Fast-db (Paris)GSHG0017509
Alternative Splicing GalleryENSG00000115211
Gene ExpressionEIF2B4 [ NCBI-GEO ]     EIF2B4 [ SEEK ]   EIF2B4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI10 (Uniprot)
NextProtQ9UI10  [Medical]
With graphics : InterProQ9UI10
Splice isoforms : SwissVarQ9UI10 (Swissvar)
Domains : Interpro (EBI)IF-2B-related [organisation]  
Related proteins : CluSTrQ9UI10
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
DMDM Disease mutations8890
Blocks (Seattle)Q9UI10
Human Protein AtlasENSG00000115211 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9UI10
HPRD09459
IPIIPI00005979   IPI00220232   IPI00654843   IPI00908922   IPI01011751   IPI00556659   IPI00893055   IPI00893169   IPI00892585   IPI00983659   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI10
IntAct (EBI)Q9UI10
FunCoupENSG00000115211
BioGRIDEIF2B4
InParanoidQ9UI10
Interologous Interaction database Q9UI10
IntegromeDBEIF2B4
STRING (EMBL)EIF2B4
Ontologies - Pathways
Ontology : AmiGOovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translation  translational initiation  translational initiation  regulation of translation  regulation of translational initiation  response to heat  response to heat  response to glucose  gene expression  oligodendrocyte development  L-methionine salvage from methylthioadenosine  translation initiation factor binding  negative regulation of translational initiation in response to stress  myelination  response to peptide hormone  positive regulation of GTPase activity  positive regulation of GTPase activity  cellular protein metabolic process  negative regulation of translational initiation  S-methyl-5-thioribose-1-phosphate isomerase activity  cellular response to stimulus  
Ontology : EGO-EBIovarian follicle development  translation initiation factor activity  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  eukaryotic translation initiation factor 2B complex  translation  translational initiation  translational initiation  regulation of translation  regulation of translational initiation  response to heat  response to heat  response to glucose  gene expression  oligodendrocyte development  L-methionine salvage from methylthioadenosine  translation initiation factor binding  negative regulation of translational initiation in response to stress  myelination  response to peptide hormone  positive regulation of GTPase activity  positive regulation of GTPase activity  cellular protein metabolic process  negative regulation of translational initiation  S-methyl-5-thioribose-1-phosphate isomerase activity  cellular response to stimulus  
Pathways : BIOCARTAVEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGRNA transport   
Protein Interaction DatabaseEIF2B4
Wikipedia pathwaysEIF2B4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EIF2B4
snp3D : Map Gene to Disease8890
SNP (GeneSNP Utah)EIF2B4
SNP : HGBaseEIF2B4
Genetic variants : HAPMAPEIF2B4
Exome VariantEIF2B4
1000_GenomesEIF2B4 
ICGC programENSG00000115211 
Somatic Mutations in Cancer : COSMICEIF2B4 
CONAN: Copy Number AnalysisEIF2B4 
Mutations and Diseases : HGMDEIF2B4
Genomic VariantsEIF2B4  EIF2B4 [DGVbeta]
dbVarEIF2B4
ClinVarEIF2B4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603896    606687   
MedgenEIF2B4
GENETestsEIF2B4
Disease Genetic AssociationEIF2B4
Huge Navigator EIF2B4 [HugePedia]  EIF2B4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneEIF2B4
Homology/Alignments : Family Browser (UCSC)EIF2B4
Phylogenetic Trees/Animal Genes : TreeFamEIF2B4
Chemical/Protein Interactions : CTD8890
Chemical/Pharm GKB GenePA27691
Clinical trialEIF2B4
Cancer Resource (Charite)ENSG00000115211
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMineEIF2B4
iHOPEIF2B4
OncoSearchEIF2B4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:52:39 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.