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EIF2D (eukaryotic translation initiation factor 2D)

Identity

Alias_symbol (synonym)LGTN
Other aliasHCA56
HGNC (Hugo) EIF2D
LocusID (NCBI) 1939
Atlas_Id 62777
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206591643 and ends at 206612551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCAF8 (1q23.2) / EIF2D (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2D   6583
Cards
Entrez_Gene (NCBI)EIF2D  1939  eukaryotic translation initiation factor 2D
AliasesHCA56; LGTN
GeneCards (Weizmann)EIF2D
Ensembl hg19 (Hinxton)ENSG00000143486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143486 [Gene_View]  chr1:206591643-206612551 [Contig_View]  EIF2D [Vega]
ICGC DataPortalENSG00000143486
TCGA cBioPortalEIF2D
AceView (NCBI)EIF2D
Genatlas (Paris)EIF2D
WikiGenes1939
SOURCE (Princeton)EIF2D
Genetics Home Reference (NIH)EIF2D
Genomic and cartography
GoldenPath hg38 (UCSC)EIF2D  -     chr1:206591643-206612551 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF2D  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblEIF2D - 1q32.1 [CytoView hg19]  EIF2D - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIEIF2D [Mapview hg19]  EIF2D [Mapview hg38]
OMIM613709   
Gene and transcription
Genbank (Entrez)AB209364 AF159586 AF220417 AF262403 AK001852
RefSeq transcript (Entrez)NM_001201478 NM_006893
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF2D
Cluster EST : UnigeneHs.497581 [ NCBI ]
CGAP (NCI)Hs.497581
Alternative Splicing GalleryENSG00000143486
Gene ExpressionEIF2D [ NCBI-GEO ]   EIF2D [ EBI - ARRAY_EXPRESS ]   EIF2D [ SEEK ]   EIF2D [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1939
GTEX Portal (Tissue expression)EIF2D
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41214   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41214  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41214
Splice isoforms : SwissVarP41214
PhosPhoSitePlusP41214
Domaine pattern : Prosite (Expaxy)PUA (PS50890)    SUI1 (PS50296)   
Domains : Interpro (EBI)PUA    PUA-like_domain    SUI1    SWIB_MDM2_domain   
Domain families : Pfam (Sanger)SUI1 (PF01253)   
Domain families : Pfam (NCBI)pfam01253   
Domain families : Smart (EMBL)PUA (SM00359)  
Conserved Domain (NCBI)EIF2D
DMDM Disease mutations1939
Blocks (Seattle)EIF2D
SuperfamilyP41214
Human Protein AtlasENSG00000143486
Peptide AtlasP41214
HPRD01057
IPIIPI00013160   IPI00183443   IPI00908382   IPI00555840   IPI00514767   
Protein Interaction databases
DIP (DOE-UCLA)P41214
IntAct (EBI)P41214
FunCoupENSG00000143486
BioGRIDEIF2D
STRING (EMBL)EIF2D
ZODIACEIF2D
Ontologies - Pathways
QuickGOP41214
Ontology : AmiGOformation of translation preinitiation complex  IRES-dependent translational initiation  translation initiation factor activity  receptor activity  cytoplasm  cytosol  intracellular protein transport  nuclear body  cytosolic small ribosomal subunit  ribosome disassembly  
Ontology : EGO-EBIformation of translation preinitiation complex  IRES-dependent translational initiation  translation initiation factor activity  receptor activity  cytoplasm  cytosol  intracellular protein transport  nuclear body  cytosolic small ribosomal subunit  ribosome disassembly  
NDEx NetworkEIF2D
Atlas of Cancer Signalling NetworkEIF2D
Wikipedia pathwaysEIF2D
Orthology - Evolution
OrthoDB1939
GeneTree (enSembl)ENSG00000143486
Phylogenetic Trees/Animal Genes : TreeFamEIF2D
HOVERGENP41214
HOGENOMP41214
Homologs : HomoloGeneEIF2D
Homology/Alignments : Family Browser (UCSC)EIF2D
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2D
dbVarEIF2D
ClinVarEIF2D
1000_GenomesEIF2D 
Exome Variant ServerEIF2D
ExAC (Exome Aggregation Consortium)EIF2D (select the gene name)
Genetic variants : HAPMAP1939
Genomic Variants (DGV)EIF2D [DGVbeta]
DECIPHEREIF2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF2D 
Mutations
ICGC Data PortalEIF2D 
TCGA Data PortalEIF2D 
Broad Tumor PortalEIF2D
OASIS PortalEIF2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF2D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF2D
DgiDB (Drug Gene Interaction Database)EIF2D
DoCM (Curated mutations)EIF2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2D (select a term)
intoGenEIF2D
Cancer3DEIF2D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613709   
Orphanet
MedgenEIF2D
Genetic Testing Registry EIF2D
NextProtP41214 [Medical]
TSGene1939
GENETestsEIF2D
Target ValidationEIF2D
Huge Navigator EIF2D [HugePedia]
snp3D : Map Gene to Disease1939
BioCentury BCIQEIF2D
ClinGenEIF2D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1939
Chemical/Pharm GKB GenePA30355
Clinical trialEIF2D
Miscellaneous
canSAR (ICR)EIF2D (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2D
EVEXEIF2D
GoPubMedEIF2D
iHOPEIF2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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