EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)

2014-01-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
EIF2,EIF2B,EIF2beta,PPP1R67,eIF-2-beta
FUSION GENES

Other Information

Locus ID:

NCBI: 8894
MIM: 603908
HGNC: 3266
Ensembl: ENSG00000125977

Variants:

dbSNP: 8894
ClinVar: 8894
TCGA: ENSG00000125977
COSMIC: EIF2S2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125977ENST00000374980P20042
ENSG00000125977ENST00000374980Q6IBR8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Recycling of eIF2:GDPREACTOMER-HSA-72731
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228137442012The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.35
266090492016Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4.7
186395292008Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation.4
296248142018eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.2

Citation

Dessen P

EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53658/eif2s2