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EIF2S3 (eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa)

Identity

Alias_namesEIF2G
eukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD)
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Alias_symbol (synonym)EIF2gamma
EIF2
Other aliaseIF-2gA
HGNC (Hugo) EIF2S3
LocusID (NCBI) 1968
Atlas_Id 62778
Location Xp22.11  [Link to chromosome band Xp22]
Location_base_pair Starts at 24073065 and ends at 24096927 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EIF2S3 (Xp22.11) / H19 (11p15.5)EIF2S3 (Xp22.11) / HNRNPA3 (2q31.2)GFPT1 (2p13.3) / EIF2S3 (Xp22.11)
SLC19A2 (1q24.2) / EIF2S3 (Xp22.11)WDR70 (5p13.2) / EIF2S3 (Xp22.11)ZNF480 (19q13.41) / EIF2S3 (Xp22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2S3   3267
Cards
Entrez_Gene (NCBI)EIF2S3  1968  eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
AliasesEIF2; EIF2G; EIF2gamma; eIF-2gA
GeneCards (Weizmann)EIF2S3
Ensembl hg19 (Hinxton) [Gene_View]  chrX:24073065-24096927 [Contig_View]  EIF2S3 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chrX:24073065-24096927 [Contig_View]  EIF2S3 [Vega]
TCGA cBioPortalEIF2S3
AceView (NCBI)EIF2S3
Genatlas (Paris)EIF2S3
WikiGenes1968
SOURCE (Princeton)EIF2S3
Genetics Home Reference (NIH)EIF2S3
Genomic and cartography
GoldenPath hg19 (UCSC)EIF2S3  -     chrX:24073065-24096927 +  Xp22.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF2S3  -     Xp22.11   [Description]    (hg38-Dec_2013)
EnsemblEIF2S3 - Xp22.11 [CytoView hg19]  EIF2S3 - Xp22.11 [CytoView hg38]
Mapping of homologs : NCBIEIF2S3 [Mapview hg19]  EIF2S3 [Mapview hg38]
OMIM300161   
Gene and transcription
Genbank (Entrez)AB451230 AB451353 AF274932 AI133612 AK222577
RefSeq transcript (Entrez)NM_001415
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_016387 NT_167197 NW_004929438
Consensus coding sequences : CCDS (NCBI)EIF2S3
Cluster EST : UnigeneHs.539684 [ NCBI ]
CGAP (NCI)Hs.539684
Gene ExpressionEIF2S3 [ NCBI-GEO ]   EIF2S3 [ EBI - ARRAY_EXPRESS ]   EIF2S3 [ SEEK ]   EIF2S3 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2S3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1968
GTEX Portal (Tissue expression)EIF2S3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41091   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41091  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41091
Splice isoforms : SwissVarP41091
PhosPhoSitePlusP41091
Domaine pattern : Prosite (Expaxy)G_TR_2 (PS51722)   
Domains : Interpro (EBI)EF_GTP-bd_dom    P-loop_NTPase    TIF2_gsu_C    Transl_B-barrel    Transl_elong_EF1A/Init_IF2_C    Transl_elong_EFTu/EF1A_2   
Domain families : Pfam (Sanger)eIF2_C (PF09173)    GTP_EFTU (PF00009)    GTP_EFTU_D2 (PF03144)   
Domain families : Pfam (NCBI)pfam09173    pfam00009    pfam03144   
Conserved Domain (NCBI)EIF2S3
DMDM Disease mutations1968
Blocks (Seattle)EIF2S3
SuperfamilyP41091
Peptide AtlasP41091
HPRD02155
IPIIPI00297982   IPI00644287   
Protein Interaction databases
DIP (DOE-UCLA)P41091
IntAct (EBI)P41091
BioGRIDEIF2S3
STRING (EMBL)EIF2S3
ZODIACEIF2S3
Ontologies - Pathways
QuickGOP41091
Ontology : AmiGOtranslation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  translation  translational initiation  translational initiation  translation factor activity, RNA binding  gene expression  cellular protein metabolic process  transmembrane transport  extracellular exosome  
Ontology : EGO-EBItranslation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  translation  translational initiation  translational initiation  translation factor activity, RNA binding  gene expression  cellular protein metabolic process  transmembrane transport  extracellular exosome  
Pathways : BIOCARTAEukaryotic protein translation [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]    Regulation of eIF2 [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkEIF2S3
Atlas of Cancer Signalling NetworkEIF2S3
Wikipedia pathwaysEIF2S3
Orthology - Evolution
OrthoDB1968
Phylogenetic Trees/Animal Genes : TreeFamEIF2S3
HOVERGENP41091
HOGENOMP41091
Homologs : HomoloGeneEIF2S3
Homology/Alignments : Family Browser (UCSC)EIF2S3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2S3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2S3
dbVarEIF2S3
ClinVarEIF2S3
1000_GenomesEIF2S3 
Exome Variant ServerEIF2S3
ExAC (Exome Aggregation Consortium)EIF2S3 (select the gene name)
Genetic variants : HAPMAP1968
Genomic Variants (DGV)EIF2S3 [DGVbeta]
DECIPHER (Syndromes)X:24073065-24096927  
CONAN: Copy Number AnalysisEIF2S3 
Mutations
ICGC Data PortalEIF2S3 
TCGA Data PortalEIF2S3 
Broad Tumor PortalEIF2S3
OASIS PortalEIF2S3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2S3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF2S3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch EIF2S3
DgiDB (Drug Gene Interaction Database)EIF2S3
DoCM (Curated mutations)EIF2S3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2S3 (select a term)
intoGenEIF2S3
Cancer3DEIF2S3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300161   
Orphanet
MedgenEIF2S3
Genetic Testing Registry EIF2S3
NextProtP41091 [Medical]
TSGene1968
GENETestsEIF2S3
Huge Navigator EIF2S3 [HugePedia]
snp3D : Map Gene to Disease1968
BioCentury BCIQEIF2S3
ClinGenEIF2S3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1968
Chemical/Pharm GKB GenePA27697
Clinical trialEIF2S3
Miscellaneous
canSAR (ICR)EIF2S3 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2S3
EVEXEIF2S3
GoPubMedEIF2S3
iHOPEIF2S3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:02:41 CET 2017

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