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EIF3B (eukaryotic translation initiation factor 3 subunit B)

Identity

Alias_namesEIF3S9
eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa
eukaryotic translation initiation factor 3, subunit B
Alias_symbol (synonym)PRT1
eIF3b
Other aliasEIF3-ETA
EIF3-P110
EIF3-P116
HGNC (Hugo) EIF3B
LocusID (NCBI) 8662
Atlas_Id 40430
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 2354839 and ends at 2380742 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3B (7p22.3) / COL6A6 (3q22.1)EIF3B (7p22.3) / EIF3B (7p22.3)EIF3B (7p22.3) / FAM107B (10p13)
EIF3B (7p22.3) / HSP90AA1 (14q32.31)EIF3B (7p22.3) / HSPG2 (1p36.12)EIF3B (7p22.3) / POLA2 (11q13.1)
EIF3B (7p22.3) / TMEM55A (8q21.3)ERGIC1 (5q35.1) / EIF3B (7p22.3)IQCE (7p22.3) / EIF3B (7p22.3)
PLEKHF1 (19q12) / EIF3B (7p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EIF3B   3280
Cards
Entrez_Gene (NCBI)EIF3B  8662  eukaryotic translation initiation factor 3 subunit B
AliasesEIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9; 
PRT1
GeneCards (Weizmann)EIF3B
Ensembl hg19 (Hinxton)ENSG00000106263 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106263 [Gene_View]  ENSG00000106263 [Sequence]  chr7:2354839-2380742 [Contig_View]  EIF3B [Vega]
ICGC DataPortalENSG00000106263
TCGA cBioPortalEIF3B
AceView (NCBI)EIF3B
Genatlas (Paris)EIF3B
WikiGenes8662
SOURCE (Princeton)EIF3B
Genetics Home Reference (NIH)EIF3B
Genomic and cartography
GoldenPath hg38 (UCSC)EIF3B  -     chr7:2354839-2380742 +  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF3B  -     7p22.3   [Description]    (hg19-Feb_2009)
EnsemblEIF3B - 7p22.3 [CytoView hg19]  EIF3B - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBIEIF3B [Mapview hg19]  EIF3B [Mapview hg38]
OMIM603917   
Gene and transcription
Genbank (Entrez)AB209381 AI888128 AK093807 AK126670 AK127885
RefSeq transcript (Entrez)NM_001037283 NM_001362791 NM_001362792 NM_001362793 NM_003751
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF3B
Cluster EST : UnigeneHs.371001 [ NCBI ]
CGAP (NCI)Hs.371001
Alternative Splicing GalleryENSG00000106263
Gene ExpressionEIF3B [ NCBI-GEO ]   EIF3B [ EBI - ARRAY_EXPRESS ]   EIF3B [ SEEK ]   EIF3B [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8662
GTEX Portal (Tissue expression)EIF3B
Human Protein AtlasENSG00000106263-EIF3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55884   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55884  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55884
Splice isoforms : SwissVarP55884
PhosPhoSitePlusP55884
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)EIF3B    eIF3B_RRM    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    TIF_beta_prop-like    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)eIF2A (PF08662)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam08662    pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)EIF3B
DMDM Disease mutations8662
Blocks (Seattle)EIF3B
PDB (SRS)2KRB    2NLW    5K1H   
PDB (PDBSum)2KRB    2NLW    5K1H   
PDB (IMB)2KRB    2NLW    5K1H   
PDB (RSDB)2KRB    2NLW    5K1H   
Structural Biology KnowledgeBase2KRB    2NLW    5K1H   
SCOP (Structural Classification of Proteins)2KRB    2NLW    5K1H   
CATH (Classification of proteins structures)2KRB    2NLW    5K1H   
SuperfamilyP55884
Human Protein Atlas [tissue]ENSG00000106263-EIF3B [tissue]
Peptide AtlasP55884
HPRD06795
IPIIPI00396370   IPI00719752   IPI00893431   IPI01025920   IPI00893301   
Protein Interaction databases
DIP (DOE-UCLA)P55884
IntAct (EBI)P55884
FunCoupENSG00000106263
BioGRIDEIF3B
STRING (EMBL)EIF3B
ZODIACEIF3B
Ontologies - Pathways
QuickGOP55884
Ontology : AmiGOformation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  translational initiation  regulation of translational initiation  eukaryotic 43S preinitiation complex  translation initiation factor binding  protein-containing complex scaffold activity  eukaryotic 48S preinitiation complex  synapse  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3m  IRES-dependent viral translational initiation  viral translational termination-reinitiation  
Ontology : EGO-EBIformation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  translational initiation  regulation of translational initiation  eukaryotic 43S preinitiation complex  translation initiation factor binding  protein-containing complex scaffold activity  eukaryotic 48S preinitiation complex  synapse  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3m  IRES-dependent viral translational initiation  viral translational termination-reinitiation  
Pathways : KEGGRNA transport   
NDEx NetworkEIF3B
Atlas of Cancer Signalling NetworkEIF3B
Wikipedia pathwaysEIF3B
Orthology - Evolution
OrthoDB8662
GeneTree (enSembl)ENSG00000106263
Phylogenetic Trees/Animal Genes : TreeFamEIF3B
HOVERGENP55884
HOGENOMP55884
Homologs : HomoloGeneEIF3B
Homology/Alignments : Family Browser (UCSC)EIF3B
Gene fusions - Rearrangements
Fusion : QuiverEIF3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3B
dbVarEIF3B
ClinVarEIF3B
1000_GenomesEIF3B 
Exome Variant ServerEIF3B
ExAC (Exome Aggregation Consortium)ENSG00000106263
GNOMAD BrowserENSG00000106263
Varsome BrowserEIF3B
Genetic variants : HAPMAP8662
Genomic Variants (DGV)EIF3B [DGVbeta]
DECIPHEREIF3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF3B 
Mutations
ICGC Data PortalEIF3B 
TCGA Data PortalEIF3B 
Broad Tumor PortalEIF3B
OASIS PortalEIF3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF3B
DgiDB (Drug Gene Interaction Database)EIF3B
DoCM (Curated mutations)EIF3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF3B (select a term)
intoGenEIF3B
Cancer3DEIF3B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603917   
Orphanet
DisGeNETEIF3B
MedgenEIF3B
Genetic Testing Registry EIF3B
NextProtP55884 [Medical]
TSGene8662
GENETestsEIF3B
Target ValidationEIF3B
Huge Navigator EIF3B [HugePedia]
snp3D : Map Gene to Disease8662
BioCentury BCIQEIF3B
ClinGenEIF3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8662
Chemical/Pharm GKB GenePA162384603
Clinical trialEIF3B
Miscellaneous
canSAR (ICR)EIF3B (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF3B
EVEXEIF3B
GoPubMedEIF3B
iHOPEIF3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:04:10 CET 2018
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