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EIF3E (eukaryotic translation initiation factor 3 subunit E)

Identity

Alias_namesINT6
EIF3S6
eukaryotic translation initiation factor 3, subunit 6 48kDa
eukaryotic translation initiation factor 3, subunit E
Alias_symbol (synonym)eIF3-p48
eIF3e
Other aliasEIF3-P48
eIF3-p46
HGNC (Hugo) EIF3E
LocusID (NCBI) 3646
Atlas_Id 40428
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 108201743 and ends at 108248730 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG5 (6q21) / EIF3E (8q23.1)EIF3E (8q23.1) / GTSE1 (22q13.31)EIF3E (8q23.1) / PDS5A (4p14)
EIF3E (8q23.1) / PRSS23 (11q14.2)EIF3E (8q23.1) / RSPO2 (8q23.1)MMP16 (8q21.3) / EIF3E (8q23.1)
EIF3E 8q23.1 / RSPO2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;8)(q21;q23) ATG5/EIF3E
EIF3E/RSPO2 (8q23)

External links

Nomenclature
HGNC (Hugo)EIF3E   3277
Cards
Entrez_Gene (NCBI)EIF3E  3646  eukaryotic translation initiation factor 3 subunit E
AliasesEIF3-P48; EIF3S6; INT6; eIF3-p46
GeneCards (Weizmann)EIF3E
Ensembl hg19 (Hinxton)ENSG00000104408 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104408 [Gene_View]  ENSG00000104408 [Sequence]  chr8:108201743-108248730 [Contig_View]  EIF3E [Vega]
ICGC DataPortalENSG00000104408
TCGA cBioPortalEIF3E
AceView (NCBI)EIF3E
Genatlas (Paris)EIF3E
WikiGenes3646
SOURCE (Princeton)EIF3E
Genetics Home Reference (NIH)EIF3E
Genomic and cartography
GoldenPath hg38 (UCSC)EIF3E  -     chr8:108201743-108248730 -  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF3E  -     8q23.1   [Description]    (hg19-Feb_2009)
EIF3E - 8q23.1 [CytoView hg19]  EIF3E - 8q23.1 [CytoView hg38]
Mapping of homologs : NCBIEIF3E [Mapview hg19]  EIF3E [Mapview hg38]
OMIM602210   
Gene and transcription
Genbank (Entrez)AK124178 AK310902 AK313186 BC000734 BC005944
RefSeq transcript (Entrez)NM_001568
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF3E
Cluster EST : UnigeneHs.405590 [ NCBI ]
CGAP (NCI)Hs.405590
Alternative Splicing GalleryENSG00000104408
Gene ExpressionEIF3E [ NCBI-GEO ]   EIF3E [ EBI - ARRAY_EXPRESS ]   EIF3E [ SEEK ]   EIF3E [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3646
GTEX Portal (Tissue expression)EIF3E
Human Protein AtlasENSG00000104408-EIF3E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60228   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60228  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60228
Splice isoforms : SwissVarP60228
PhosPhoSitePlusP60228
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)eIF3e    eIF3e_N    PCI_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)eIF3_N (PF09440)    PCI (PF01399)   
Domain families : Pfam (NCBI)pfam09440    pfam01399   
Domain families : Smart (EMBL)eIF3_N (SM01186)  PINT (SM00088)  
Conserved Domain (NCBI)EIF3E
DMDM Disease mutations3646
Blocks (Seattle)EIF3E
PDB (RSDB)3J8B    3J8C    6FEC   
PDB Europe3J8B    3J8C    6FEC   
PDB (PDBSum)3J8B    3J8C    6FEC   
PDB (IMB)3J8B    3J8C    6FEC   
Structural Biology KnowledgeBase3J8B    3J8C    6FEC   
SCOP (Structural Classification of Proteins)3J8B    3J8C    6FEC   
CATH (Classification of proteins structures)3J8B    3J8C    6FEC   
SuperfamilyP60228
Human Protein Atlas [tissue]ENSG00000104408-EIF3E [tissue]
Peptide AtlasP60228
HPRD03734
IPIIPI00013068   IPI00984035   IPI00974080   IPI00974294   IPI00973922   IPI00977156   IPI00976006   IPI00974151   IPI01015563   IPI00977424   
Protein Interaction databases
DIP (DOE-UCLA)P60228
IntAct (EBI)P60228
FunCoupENSG00000104408
BioGRIDEIF3E
STRING (EMBL)EIF3E
ZODIACEIF3E
Ontologies - Pathways
QuickGOP60228
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  chromatin  formation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  translational initiation  regulation of translational initiation  membrane  eukaryotic 43S preinitiation complex  nuclear body  PML body  eukaryotic 48S preinitiation complex  cadherin binding  positive regulation of translation  negative regulation of translational initiation  protein N-terminus binding  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3e  positive regulation of mRNA binding  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  chromatin  formation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  translational initiation  regulation of translational initiation  membrane  eukaryotic 43S preinitiation complex  nuclear body  PML body  eukaryotic 48S preinitiation complex  cadherin binding  positive regulation of translation  negative regulation of translational initiation  protein N-terminus binding  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3e  positive regulation of mRNA binding  
Pathways : KEGGRNA transport    Hepatitis C   
NDEx NetworkEIF3E
Atlas of Cancer Signalling NetworkEIF3E
Wikipedia pathwaysEIF3E
Orthology - Evolution
OrthoDB3646
GeneTree (enSembl)ENSG00000104408
Phylogenetic Trees/Animal Genes : TreeFamEIF3E
HOGENOMP60228
Homologs : HomoloGeneEIF3E
Homology/Alignments : Family Browser (UCSC)EIF3E
Gene fusions - Rearrangements
Fusion : MitelmanEIF3E/RSPO2 [8q23.1/8q23.1]  
Fusion : QuiverEIF3E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3E
dbVarEIF3E
ClinVarEIF3E
1000_GenomesEIF3E 
Exome Variant ServerEIF3E
ExAC (Exome Aggregation Consortium)ENSG00000104408
GNOMAD BrowserENSG00000104408
Varsome BrowserEIF3E
Genetic variants : HAPMAP3646
Genomic Variants (DGV)EIF3E [DGVbeta]
DECIPHEREIF3E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF3E 
Mutations
ICGC Data PortalEIF3E 
TCGA Data PortalEIF3E 
Broad Tumor PortalEIF3E
OASIS PortalEIF3E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF3E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF3E
DgiDB (Drug Gene Interaction Database)EIF3E
DoCM (Curated mutations)EIF3E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF3E (select a term)
intoGenEIF3E
Cancer3DEIF3E(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602210   
Orphanet
DisGeNETEIF3E
MedgenEIF3E
Genetic Testing Registry EIF3E
NextProtP60228 [Medical]
TSGene3646
GENETestsEIF3E
Target ValidationEIF3E
Huge Navigator EIF3E [HugePedia]
snp3D : Map Gene to Disease3646
BioCentury BCIQEIF3E
ClinGenEIF3E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3646
Chemical/Pharm GKB GenePA27705
Clinical trialEIF3E
Miscellaneous
canSAR (ICR)EIF3E (select the gene name)
DataMed IndexEIF3E
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF3E
EVEXEIF3E
GoPubMedEIF3E
iHOPEIF3E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu May 2 12:47:35 CEST 2019
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