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EIF3H (eukaryotic translation initiation factor 3 subunit H)

Identity

Alias_namesEIF3S3
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
eukaryotic translation initiation factor 3, subunit H
Alias_symbol (synonym)eIF3-gamma
eIF3-p40
eIF3h
Other alias
HGNC (Hugo) EIF3H
LocusID (NCBI) 8667
Atlas_Id 40427
Location 8q23.3  [Link to chromosome band 8q23]
Location_base_pair Starts at 116644816 and ends at 116755823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYTH1 (17q25.3) / EIF3H (8q23.3)EIF3H (8q23.3) / ACSL5 (10q25.2)EIF3H (8q23.3) / CMC1 (3p24.1)
EIF3H (8q23.3) / EIF3H (8q23.3)EIF3H (8q23.3) / FAM65C (20q13.13)EIF3H (8q23.3) / NRL (14q11.2)
FAM129B (9q33.3) / EIF3H (8q23.3)RAD21 (8q24.11) / EIF3H (8q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF3H   3273
Cards
Entrez_Gene (NCBI)EIF3H  8667  eukaryotic translation initiation factor 3 subunit H
AliasesEIF3S3; eIF3-gamma; eIF3-p40
GeneCards (Weizmann)EIF3H
Ensembl hg19 (Hinxton)ENSG00000147677 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147677 [Gene_View]  chr8:116644816-116755823 [Contig_View]  EIF3H [Vega]
ICGC DataPortalENSG00000147677
TCGA cBioPortalEIF3H
AceView (NCBI)EIF3H
Genatlas (Paris)EIF3H
WikiGenes8667
SOURCE (Princeton)EIF3H
Genetics Home Reference (NIH)EIF3H
Genomic and cartography
GoldenPath hg38 (UCSC)EIF3H  -     chr8:116644816-116755823 -  8q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF3H  -     8q23.3   [Description]    (hg19-Feb_2009)
EnsemblEIF3H - 8q23.3 [CytoView hg19]  EIF3H - 8q23.3 [CytoView hg38]
Mapping of homologs : NCBIEIF3H [Mapview hg19]  EIF3H [Mapview hg38]
OMIM603912   
Gene and transcription
Genbank (Entrez)AA902770 AK093128 AK222520 AK222620 AK296162
RefSeq transcript (Entrez)NM_003756
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF3H
Cluster EST : UnigeneHs.492599 [ NCBI ]
CGAP (NCI)Hs.492599
Alternative Splicing GalleryENSG00000147677
Gene ExpressionEIF3H [ NCBI-GEO ]   EIF3H [ EBI - ARRAY_EXPRESS ]   EIF3H [ SEEK ]   EIF3H [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8667
GTEX Portal (Tissue expression)EIF3H
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15372   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15372  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15372
Splice isoforms : SwissVarO15372
PhosPhoSitePlusO15372
Domains : Interpro (EBI)eIF3h    JAMM/MPN+_dom   
Domain families : Pfam (Sanger)JAB (PF01398)   
Domain families : Pfam (NCBI)pfam01398   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)EIF3H
DMDM Disease mutations8667
Blocks (Seattle)EIF3H
PDB (SRS)3J8B    3J8C   
PDB (PDBSum)3J8B    3J8C   
PDB (IMB)3J8B    3J8C   
PDB (RSDB)3J8B    3J8C   
Structural Biology KnowledgeBase3J8B    3J8C   
SCOP (Structural Classification of Proteins)3J8B    3J8C   
CATH (Classification of proteins structures)3J8B    3J8C   
SuperfamilyO15372
Human Protein AtlasENSG00000147677
Peptide AtlasO15372
HPRD04885
IPIIPI00977658   IPI00647650   IPI00973775   IPI01011241   IPI00789224   IPI01010398   IPI00972949   IPI00984356   
Protein Interaction databases
DIP (DOE-UCLA)O15372
IntAct (EBI)O15372
FunCoupENSG00000147677
BioGRIDEIF3H
STRING (EMBL)EIF3H
ZODIACEIF3H
Ontologies - Pathways
QuickGOO15372
Ontology : AmiGORNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  regulation of translational initiation  membrane  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3m  
Ontology : EGO-EBIRNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  regulation of translational initiation  membrane  extracellular exosome  eukaryotic translation initiation factor 3 complex, eIF3m  
Pathways : KEGGRNA transport    Measles   
NDEx NetworkEIF3H
Atlas of Cancer Signalling NetworkEIF3H
Wikipedia pathwaysEIF3H
Orthology - Evolution
OrthoDB8667
GeneTree (enSembl)ENSG00000147677
Phylogenetic Trees/Animal Genes : TreeFamEIF3H
HOVERGENO15372
HOGENOMO15372
Homologs : HomoloGeneEIF3H
Homology/Alignments : Family Browser (UCSC)EIF3H
Gene fusions - Rearrangements
Fusion : MitelmanCYTH1/EIF3H [17q25.3/8q23.3]  [t(8;17)(q24;q25)]  
Fusion : MitelmanEIF3H/FAM65C [8q23.3/20q13.13]  [t(8;20)(q24;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3H
dbVarEIF3H
ClinVarEIF3H
1000_GenomesEIF3H 
Exome Variant ServerEIF3H
ExAC (Exome Aggregation Consortium)EIF3H (select the gene name)
Genetic variants : HAPMAP8667
Genomic Variants (DGV)EIF3H [DGVbeta]
DECIPHEREIF3H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF3H 
Mutations
ICGC Data PortalEIF3H 
TCGA Data PortalEIF3H 
Broad Tumor PortalEIF3H
OASIS PortalEIF3H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF3H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF3H
DgiDB (Drug Gene Interaction Database)EIF3H
DoCM (Curated mutations)EIF3H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF3H (select a term)
intoGenEIF3H
Cancer3DEIF3H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603912   
Orphanet
MedgenEIF3H
Genetic Testing Registry EIF3H
NextProtO15372 [Medical]
TSGene8667
GENETestsEIF3H
Target ValidationEIF3H
Huge Navigator EIF3H [HugePedia]
snp3D : Map Gene to Disease8667
BioCentury BCIQEIF3H
ClinGenEIF3H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8667
Chemical/Pharm GKB GenePA162384854
Clinical trialEIF3H
Miscellaneous
canSAR (ICR)EIF3H (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF3H
EVEXEIF3H
GoPubMedEIF3H
iHOPEIF3H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:06:41 CEST 2017

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