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EIF3H (eukaryotic translation initiation factor 3 subunit H)

Identity

Alias (NCBI)EIF3S3
eIF3-gamma
eIF3-p40
HGNC (Hugo) EIF3H
HGNC Alias symbeIF3-gamma
eIF3-p40
HGNC Previous nameEIF3S3
HGNC Previous nameeukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa
 eukaryotic translation initiation factor 3, subunit H
LocusID (NCBI) 8667
Atlas_Id 40427
Location 8q23.3  [Link to chromosome band 8q23]
Location_base_pair Starts at 116642131 and ends at 116755823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYTH1 (17q25.3) / EIF3H (8q23.3)EIF3H (8q23.3) / ACSL5 (10q25.2)EIF3H (8q23.3) / CMC1 (3p24.1)
EIF3H (8q23.3) / EIF3H (8q23.3)EIF3H (8q23.3) / FAM65C (20q13.13)EIF3H (8q23.3) / NRL (14q11.2)
FAM129B (9q33.3) / EIF3H (8q23.3)RAD21 (8q24.11) / EIF3H (8q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EIF3H   3273
Cards
Entrez_Gene (NCBI)EIF3H    eukaryotic translation initiation factor 3 subunit H
AliasesEIF3S3; eIF3-gamma; eIF3-p40
GeneCards (Weizmann)EIF3H
Ensembl hg19 (Hinxton)ENSG00000147677 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147677 [Gene_View]  ENSG00000147677 [Sequence]  chr8:116642131-116755823 [Contig_View]  EIF3H [Vega]
ICGC DataPortalENSG00000147677
TCGA cBioPortalEIF3H
AceView (NCBI)EIF3H
Genatlas (Paris)EIF3H
SOURCE (Princeton)EIF3H
Genetics Home Reference (NIH)EIF3H
Genomic and cartography
GoldenPath hg38 (UCSC)EIF3H  -     chr8:116642131-116755823 -  8q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF3H  -     8q23.3   [Description]    (hg19-Feb_2009)
GoldenPathEIF3H - 8q23.3 [CytoView hg19]  EIF3H - 8q23.3 [CytoView hg38]
ImmunoBaseENSG00000147677
Genome Data Viewer NCBIEIF3H [Mapview hg19]  
OMIM603912   
Gene and transcription
Genbank (Entrez)AA902770 AK093128 AK222520 AK222620 AK296162
RefSeq transcript (Entrez)NM_003756
Consensus coding sequences : CCDS (NCBI)EIF3H
Gene ExpressionEIF3H [ NCBI-GEO ]   EIF3H [ EBI - ARRAY_EXPRESS ]   EIF3H [ SEEK ]   EIF3H [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3H [ Firebrowse - Broad ]
GenevisibleExpression of EIF3H in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8667
GTEX Portal (Tissue expression)EIF3H
Human Protein AtlasENSG00000147677-EIF3H [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15372   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15372  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15372
PhosPhoSitePlusO15372
Domaine pattern : Prosite (Expaxy)MPN (PS50249)   
Domains : Interpro (EBI)eIF3h    JAMM/MPN+_dom    MPN   
Domain families : Pfam (Sanger)JAB (PF01398)   
Domain families : Pfam (NCBI)pfam01398   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)EIF3H
PDB (RSDB)3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
PDB Europe3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
PDB (PDBSum)3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
PDB (IMB)3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
Structural Biology KnowledgeBase3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
SCOP (Structural Classification of Proteins)3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
CATH (Classification of proteins structures)3J8B    3J8C    6YBD    6ZMW    6ZON    6ZP4    6ZVJ    7A09   
SuperfamilyO15372
AlphaFold pdb e-kbO15372   
Human Protein Atlas [tissue]ENSG00000147677-EIF3H [tissue]
HPRD04885
Protein Interaction databases
DIP (DOE-UCLA)O15372
IntAct (EBI)O15372
BioGRIDEIF3H
STRING (EMBL)EIF3H
ZODIACEIF3H
Ontologies - Pathways
QuickGOO15372
Ontology : AmiGOformation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  regulation of translational initiation  proteolysis  metallopeptidase activity  metallopeptidase activity  membrane  eukaryotic 43S preinitiation complex  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  eukaryotic 48S preinitiation complex  polysomal ribosome  extracellular exosome  isopeptidase activity  eukaryotic translation initiation factor 3 complex, eIF3m  deubiquitinase activity  
Ontology : EGO-EBIformation of cytoplasmic translation initiation complex  RNA binding  translation initiation factor activity  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  cytosol  eukaryotic translation initiation factor 3 complex  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  regulation of translational initiation  proteolysis  metallopeptidase activity  metallopeptidase activity  membrane  eukaryotic 43S preinitiation complex  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  eukaryotic 48S preinitiation complex  polysomal ribosome  extracellular exosome  isopeptidase activity  eukaryotic translation initiation factor 3 complex, eIF3m  deubiquitinase activity  
Pathways : KEGGRNA transport    Measles   
NDEx NetworkEIF3H
Atlas of Cancer Signalling NetworkEIF3H
Wikipedia pathwaysEIF3H
Orthology - Evolution
OrthoDB8667
GeneTree (enSembl)ENSG00000147677
Phylogenetic Trees/Animal Genes : TreeFamEIF3H
Homologs : HomoloGeneEIF3H
Homology/Alignments : Family Browser (UCSC)EIF3H
Gene fusions - Rearrangements
Fusion : MitelmanCYTH1/EIF3H [17q25.3/8q23.3]  
Fusion : MitelmanEIF3H/FAM65C [8q23.3/20q13.13]  
Fusion : QuiverEIF3H
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3H
dbVarEIF3H
ClinVarEIF3H
MonarchEIF3H
1000_GenomesEIF3H 
Exome Variant ServerEIF3H
GNOMAD BrowserENSG00000147677
Varsome BrowserEIF3H
ACMGEIF3H variants
VarityO15372
Genomic Variants (DGV)EIF3H [DGVbeta]
DECIPHEREIF3H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF3H 
Mutations
ICGC Data PortalEIF3H 
TCGA Data PortalEIF3H 
Broad Tumor PortalEIF3H
OASIS PortalEIF3H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3H  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF3H
Mutations and Diseases : HGMDEIF3H
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEIF3H
DgiDB (Drug Gene Interaction Database)EIF3H
DoCM (Curated mutations)EIF3H
CIViC (Clinical Interpretations of Variants in Cancer)EIF3H
Cancer3DEIF3H
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603912   
Orphanet
DisGeNETEIF3H
MedgenEIF3H
Genetic Testing Registry EIF3H
NextProtO15372 [Medical]
GENETestsEIF3H
Target ValidationEIF3H
Huge Navigator EIF3H [HugePedia]
ClinGenEIF3H
Clinical trials, drugs, therapy
MyCancerGenomeEIF3H
Protein Interactions : CTDEIF3H
Pharm GKB GenePA162384854
PharosO15372
Clinical trialEIF3H
Miscellaneous
canSAR (ICR)EIF3H
HarmonizomeEIF3H
DataMed IndexEIF3H
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEIF3H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:54 CEST 2021

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