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EIF3L (eukaryotic translation initiation factor 3 subunit L)

Identity

Alias_namesEIF3S6IP
EIF3EIP
eukaryotic translation initiation factor 3, subunit 6 interacting protein
eukaryotic translation initiation factor 3, subunit E interacting protein
eukaryotic translation initiation factor 3, subunit L
Alias_symbol (synonym)HSPC021
HSPC025
EIF3S11
Other aliasMSTP005
HGNC (Hugo) EIF3L
LocusID (NCBI) 51386
Atlas_Id 62783
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 37849372 and ends at 37888782 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCZ1B (7p22.1) / EIF3L (22q13.1)EIF3L (22q13.1) / ASCC2 (22q12.2)EIF3L (22q13.1) / EIF3L (22q13.1)
EIF3L (22q13.1) / LOC440934 (2q36.1)EIF3L (22q13.1) / MTUS1 (8p22)EIF3L (22q13.1) / SEPT6 (Xq24)
LOC100507412 (-) / EIF3L (22q13.1)MARS (12q13.3) / EIF3L (22q13.1)MICALL1 (22q13.1) / EIF3L (22q13.1)
TMEM33 (4p13) / EIF3L (22q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF3L   18138
Cards
Entrez_Gene (NCBI)EIF3L  51386  eukaryotic translation initiation factor 3 subunit L
AliasesEIF3EIP; EIF3S11; EIF3S6IP; HSPC021; 
HSPC025; MSTP005
GeneCards (Weizmann)EIF3L
Ensembl hg19 (Hinxton)ENSG00000100129 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100129 [Gene_View]  chr22:37849372-37888782 [Contig_View]  EIF3L [Vega]
ICGC DataPortalENSG00000100129
TCGA cBioPortalEIF3L
AceView (NCBI)EIF3L
Genatlas (Paris)EIF3L
WikiGenes51386
SOURCE (Princeton)EIF3L
Genetics Home Reference (NIH)EIF3L
Genomic and cartography
GoldenPath hg38 (UCSC)EIF3L  -     chr22:37849372-37888782 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF3L  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblEIF3L - 22q13.1 [CytoView hg19]  EIF3L - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBIEIF3L [Mapview hg19]  EIF3L [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF077207 AF083243 AF109359 AK027429 AK056129
RefSeq transcript (Entrez)NM_001242923 NM_016091
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF3L
Cluster EST : UnigeneHs.446852 [ NCBI ]
CGAP (NCI)Hs.446852
Alternative Splicing GalleryENSG00000100129
Gene ExpressionEIF3L [ NCBI-GEO ]   EIF3L [ EBI - ARRAY_EXPRESS ]   EIF3L [ SEEK ]   EIF3L [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51386
GTEX Portal (Tissue expression)EIF3L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y262   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y262  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y262
Splice isoforms : SwissVarQ9Y262
PhosPhoSitePlusQ9Y262
Domains : Interpro (EBI)eIF3l    TPR-like_helical_dom   
Domain families : Pfam (Sanger)Paf67 (PF10255)   
Domain families : Pfam (NCBI)pfam10255   
Conserved Domain (NCBI)EIF3L
DMDM Disease mutations51386
Blocks (Seattle)EIF3L
PDB (SRS)3J8B    3J8C   
PDB (PDBSum)3J8B    3J8C   
PDB (IMB)3J8B    3J8C   
PDB (RSDB)3J8B    3J8C   
Structural Biology KnowledgeBase3J8B    3J8C   
SCOP (Structural Classification of Proteins)3J8B    3J8C   
CATH (Classification of proteins structures)3J8B    3J8C   
SuperfamilyQ9Y262
Human Protein AtlasENSG00000100129
Peptide AtlasQ9Y262
HPRD10932
IPIIPI00745266   IPI00465233   IPI01018027   IPI00910633   IPI00910422   IPI01015554   IPI00877598   IPI00877935   IPI00878788   IPI00878298   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y262
IntAct (EBI)Q9Y262
FunCoupENSG00000100129
BioGRIDEIF3L
STRING (EMBL)EIF3L
ZODIACEIF3L
Ontologies - Pathways
QuickGOQ9Y262
Ontology : AmiGOfibrillar center  RNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  nucleoplasm  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  membrane  viral translational termination-reinitiation  
Ontology : EGO-EBIfibrillar center  RNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  nucleoplasm  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  translational initiation  membrane  viral translational termination-reinitiation  
NDEx NetworkEIF3L
Atlas of Cancer Signalling NetworkEIF3L
Wikipedia pathwaysEIF3L
Orthology - Evolution
OrthoDB51386
GeneTree (enSembl)ENSG00000100129
Phylogenetic Trees/Animal Genes : TreeFamEIF3L
HOVERGENQ9Y262
HOGENOMQ9Y262
Homologs : HomoloGeneEIF3L
Homology/Alignments : Family Browser (UCSC)EIF3L
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3L
dbVarEIF3L
ClinVarEIF3L
1000_GenomesEIF3L 
Exome Variant ServerEIF3L
ExAC (Exome Aggregation Consortium)EIF3L (select the gene name)
Genetic variants : HAPMAP51386
Genomic Variants (DGV)EIF3L [DGVbeta]
DECIPHEREIF3L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF3L 
Mutations
ICGC Data PortalEIF3L 
TCGA Data PortalEIF3L 
Broad Tumor PortalEIF3L
OASIS PortalEIF3L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF3L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF3L
DgiDB (Drug Gene Interaction Database)EIF3L
DoCM (Curated mutations)EIF3L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF3L (select a term)
intoGenEIF3L
Cancer3DEIF3L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenEIF3L
Genetic Testing Registry EIF3L
NextProtQ9Y262 [Medical]
TSGene51386
GENETestsEIF3L
Target ValidationEIF3L
Huge Navigator EIF3L [HugePedia]
snp3D : Map Gene to Disease51386
BioCentury BCIQEIF3L
ClinGenEIF3L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51386
Chemical/Pharm GKB GenePA27706
Clinical trialEIF3L
Miscellaneous
canSAR (ICR)EIF3L (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF3L
EVEXEIF3L
GoPubMedEIF3L
iHOPEIF3L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:46:58 CEST 2017

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