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EIF3M (eukaryotic translation initiation factor 3 subunit M)

Identity

Alias_namesPCID1
PCI domain containing 1 (herpesvirus entry mediator)
eukaryotic translation initiation factor 3, subunit M
Alias_symbol (synonym)hfl-B5
FLJ29030
GA17
eIF3m
TANGO7
Other aliasB5
HGNC (Hugo) EIF3M
LocusID (NCBI) 10480
Atlas_Id 52139
Location 11p13  [Link to chromosome band 11p13]
Location_base_pair Starts at 32605313 and ends at 32624419 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP6AP2 (Xp11.4) / EIF3M (11p13)CSTF3 (11p13) / EIF3M (11p13)EIF3M (11p13) / EIF3M (11p13)
EIF3M (11p13) / KRT7 (12q13.13)EIF3M (11p13) / MPPED2 (11p14.1)EIF3M (11p13) / PPIE (1p34.2)
EIF3M (11p13) / SYNCRIP (6q14.3)PDHX (11p13) / EIF3M (11p13)SSRP1 (11q12.1) / EIF3M (11p13)
UPF1 (19p13.11) / EIF3M (11p13)ATP6AP2 Xp11.4 / EIF3M 11p13PDHX 11p13 / EIF3M 11p13
UPF1 19p13.11 / EIF3M 11p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)EIF3M   24460
Cards
Entrez_Gene (NCBI)EIF3M  10480  eukaryotic translation initiation factor 3 subunit M
AliasesB5; GA17; PCID1; TANGO7; 
hfl-B5
GeneCards (Weizmann)EIF3M
Ensembl hg19 (Hinxton)ENSG00000149100 [Gene_View]  chr11:32605313-32624419 [Contig_View]  EIF3M [Vega]
Ensembl hg38 (Hinxton)ENSG00000149100 [Gene_View]  chr11:32605313-32624419 [Contig_View]  EIF3M [Vega]
ICGC DataPortalENSG00000149100
TCGA cBioPortalEIF3M
AceView (NCBI)EIF3M
Genatlas (Paris)EIF3M
WikiGenes10480
SOURCE (Princeton)EIF3M
Genetics Home Reference (NIH)EIF3M
Genomic and cartography
GoldenPath hg19 (UCSC)EIF3M  -     chr11:32605313-32624419 +  11p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF3M  -     11p13   [Description]    (hg38-Dec_2013)
EnsemblEIF3M - 11p13 [CytoView hg19]  EIF3M - 11p13 [CytoView hg38]
Mapping of homologs : NCBIEIF3M [Mapview hg19]  EIF3M [Mapview hg38]
OMIM609641   
Gene and transcription
Genbank (Entrez)AF064603 AF277183 AK001768 AK131064 AK222564
RefSeq transcript (Entrez)NM_001307929 NM_006360
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)EIF3M
Cluster EST : UnigeneHs.502244 [ NCBI ]
CGAP (NCI)Hs.502244
Alternative Splicing GalleryENSG00000149100
Gene ExpressionEIF3M [ NCBI-GEO ]   EIF3M [ EBI - ARRAY_EXPRESS ]   EIF3M [ SEEK ]   EIF3M [ MEM ]
Gene Expression Viewer (FireBrowse)EIF3M [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10480
GTEX Portal (Tissue expression)EIF3M
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L2H7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L2H7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L2H7
Splice isoforms : SwissVarQ7L2H7
PhosPhoSitePlusQ7L2H7
Domains : Interpro (EBI)ARM-type_fold    eIF3m    PCI_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)PCI (PF01399)   
Domain families : Pfam (NCBI)pfam01399   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)EIF3M
DMDM Disease mutations10480
Blocks (Seattle)EIF3M
PDB (SRS)3J8B    3J8C   
PDB (PDBSum)3J8B    3J8C   
PDB (IMB)3J8B    3J8C   
PDB (RSDB)3J8B    3J8C   
Structural Biology KnowledgeBase3J8B    3J8C   
SCOP (Structural Classification of Proteins)3J8B    3J8C   
CATH (Classification of proteins structures)3J8B    3J8C   
SuperfamilyQ7L2H7
Human Protein AtlasENSG00000149100
Peptide AtlasQ7L2H7
HPRD09969
IPIIPI00102069   IPI00983383   IPI00909759   IPI00984480   IPI00980809   IPI00984713   IPI00979853   IPI00981251   IPI00982537   
Protein Interaction databases
DIP (DOE-UCLA)Q7L2H7
IntAct (EBI)Q7L2H7
FunCoupENSG00000149100
BioGRIDEIF3M
STRING (EMBL)EIF3M
ZODIACEIF3M
Ontologies - Pathways
QuickGOQ7L2H7
Ontology : AmiGOformation of translation preinitiation complex  cytoplasmic translational initiation  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  regulation of translational initiation  eukaryotic 43S preinitiation complex  translation initiation factor binding  eukaryotic 48S preinitiation complex  eukaryotic translation initiation factor 3 complex, eIF3m  
Ontology : EGO-EBIformation of translation preinitiation complex  cytoplasmic translational initiation  translation initiation factor activity  protein binding  cytosol  eukaryotic translation initiation factor 3 complex  translational initiation  translational initiation  regulation of translational initiation  eukaryotic 43S preinitiation complex  translation initiation factor binding  eukaryotic 48S preinitiation complex  eukaryotic translation initiation factor 3 complex, eIF3m  
NDEx NetworkEIF3M
Atlas of Cancer Signalling NetworkEIF3M
Wikipedia pathwaysEIF3M
Orthology - Evolution
OrthoDB10480
GeneTree (enSembl)ENSG00000149100
Phylogenetic Trees/Animal Genes : TreeFamEIF3M
HOVERGENQ7L2H7
HOGENOMQ7L2H7
Homologs : HomoloGeneEIF3M
Homology/Alignments : Family Browser (UCSC)EIF3M
Gene fusions - Rearrangements
Fusion : MitelmanATP6AP2/EIF3M [Xp11.4/11p13]  [t(X;11)(p11;p13)]  
Fusion : MitelmanEIF3M/MPPED2 [11p13/11p14.1]  [t(11;11)(p13;p14)]  
Fusion : MitelmanUPF1/EIF3M [19p13.11/11p13]  [t(11;19)(p13;p13)]  
Fusion: TCGAATP6AP2 Xp11.4 EIF3M 11p13 PRAD
Fusion: TCGAPDHX 11p13 EIF3M 11p13 BRCA
Fusion: TCGAUPF1 19p13.11 EIF3M 11p13 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF3M [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF3M
dbVarEIF3M
ClinVarEIF3M
1000_GenomesEIF3M 
Exome Variant ServerEIF3M
ExAC (Exome Aggregation Consortium)EIF3M (select the gene name)
Genetic variants : HAPMAP10480
Genomic Variants (DGV)EIF3M [DGVbeta]
DECIPHER (Syndromes)11:32605313-32624419  ENSG00000149100
CONAN: Copy Number AnalysisEIF3M 
Mutations
ICGC Data PortalEIF3M 
TCGA Data PortalEIF3M 
Broad Tumor PortalEIF3M
OASIS PortalEIF3M [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF3M  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF3M
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF3M
DgiDB (Drug Gene Interaction Database)EIF3M
DoCM (Curated mutations)EIF3M (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF3M (select a term)
intoGenEIF3M
Cancer3DEIF3M(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609641   
Orphanet
MedgenEIF3M
Genetic Testing Registry EIF3M
NextProtQ7L2H7 [Medical]
TSGene10480
GENETestsEIF3M
Huge Navigator EIF3M [HugePedia]
snp3D : Map Gene to Disease10480
BioCentury BCIQEIF3M
ClinGenEIF3M
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10480
Chemical/Pharm GKB GenePA162384944
Clinical trialEIF3M
Miscellaneous
canSAR (ICR)EIF3M (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF3M
EVEXEIF3M
GoPubMedEIF3M
iHOPEIF3M
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:59:54 CEST 2017

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