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EIF4A1 (eukaryotic translation initiation factor 4A1)

Identity

Alias_namesEIF4A
eukaryotic translation initiation factor 4A
Alias_symbol (synonym)DDX2A
EIF-4A
Other aliaseIF-4A-I
eIF4A-I
HGNC (Hugo) EIF4A1
LocusID (NCBI) 1973
Atlas_Id 46639
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7572706 and ends at 7579006 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTSL (9q21.33) / EIF4A1 (17p13.1)EIF4A1 (17p13.1) / EIF4A1 (17p13.1)EIF4A1 (17p13.1) / HSPA2 (14q23.3)
EIF4A1 (17p13.1) / PHOSPHO1 (17q21.32)FAM120A (9q22.31) / EIF4A1 (17p13.1)NOM1 (7q36.3) / EIF4A1 (17p13.1)
NRF1 (7q32.2) / EIF4A1 (17p13.1)RPL37A (2q35) / EIF4A1 (17p13.1)TMEM223 (11q12.3) / EIF4A1 (17p13.1)
TRAF7 (16p13.3) / EIF4A1 (17p13.1)EIF4A1 17p13.1 / PHOSPHO1 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(p13;q21) EIF4A1/PHOSPHO1

External links

Nomenclature
HGNC (Hugo)EIF4A1   3282
Cards
Entrez_Gene (NCBI)EIF4A1  1973  eukaryotic translation initiation factor 4A1
AliasesDDX2A; EIF-4A; EIF4A; eIF-4A-I; 
eIF4A-I
GeneCards (Weizmann)EIF4A1
Ensembl hg19 (Hinxton)ENSG00000161960 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161960 [Gene_View]  ENSG00000161960 [Sequence]  chr17:7572706-7579006 [Contig_View]  EIF4A1 [Vega]
ICGC DataPortalENSG00000161960
TCGA cBioPortalEIF4A1
AceView (NCBI)EIF4A1
Genatlas (Paris)EIF4A1
WikiGenes1973
SOURCE (Princeton)EIF4A1
Genetics Home Reference (NIH)EIF4A1
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4A1  -     chr17:7572706-7579006 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4A1  -     17p13.1   [Description]    (hg19-Feb_2009)
EIF4A1 - 17p13.1 [CytoView hg19]  EIF4A1 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIEIF4A1 [Mapview hg19]  EIF4A1 [Mapview hg38]
OMIM602641   
Gene and transcription
Genbank (Entrez)AA446856 AK130082 AK289453 AK291971 AK296664
RefSeq transcript (Entrez)NM_001204510 NM_001416
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF4A1
Cluster EST : UnigeneHs.129673 [ NCBI ]
CGAP (NCI)Hs.129673
Alternative Splicing GalleryENSG00000161960
Gene ExpressionEIF4A1 [ NCBI-GEO ]   EIF4A1 [ EBI - ARRAY_EXPRESS ]   EIF4A1 [ SEEK ]   EIF4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1973
GTEX Portal (Tissue expression)EIF4A1
Human Protein AtlasENSG00000161960-EIF4A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60842   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60842  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60842
Splice isoforms : SwissVarP60842
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusP60842
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    EIF4A    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)EIF4A1
DMDM Disease mutations1973
Blocks (Seattle)EIF4A1
PDB (RSDB)2G9N    2ZU6    3EIQ   
PDB Europe2G9N    2ZU6    3EIQ   
PDB (PDBSum)2G9N    2ZU6    3EIQ   
PDB (IMB)2G9N    2ZU6    3EIQ   
Structural Biology KnowledgeBase2G9N    2ZU6    3EIQ   
SCOP (Structural Classification of Proteins)2G9N    2ZU6    3EIQ   
CATH (Classification of proteins structures)2G9N    2ZU6    3EIQ   
SuperfamilyP60842
Human Protein Atlas [tissue]ENSG00000161960-EIF4A1 [tissue]
Peptide AtlasP60842
HPRD04030
IPIIPI00025491   IPI01012993   IPI00910691   IPI01008914   
Protein Interaction databases
DIP (DOE-UCLA)P60842
IntAct (EBI)P60842
FunCoupENSG00000161960
BioGRIDEIF4A1
STRING (EMBL)EIF4A1
ZODIACEIF4A1
Ontologies - Pathways
QuickGOP60842
Ontology : AmiGORNA cap binding  RNA binding  double-stranded RNA binding  mRNA binding  translation initiation factor activity  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  translational initiation  translation factor activity, RNA binding  membrane  viral process  eukaryotic translation initiation factor 4F complex  extracellular exosome  
Ontology : EGO-EBIRNA cap binding  RNA binding  double-stranded RNA binding  mRNA binding  translation initiation factor activity  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  translational initiation  translation factor activity, RNA binding  membrane  viral process  eukaryotic translation initiation factor 4F complex  extracellular exosome  
Pathways : KEGGRNA transport   
NDEx NetworkEIF4A1
Atlas of Cancer Signalling NetworkEIF4A1
Wikipedia pathwaysEIF4A1
Orthology - Evolution
OrthoDB1973
GeneTree (enSembl)ENSG00000161960
Phylogenetic Trees/Animal Genes : TreeFamEIF4A1
HOGENOMP60842
Homologs : HomoloGeneEIF4A1
Homology/Alignments : Family Browser (UCSC)EIF4A1
Gene fusions - Rearrangements
Fusion : MitelmanEIF4A1/PHOSPHO1 [17p13.1/17q21.32]  
Fusion PortalEIF4A1 17p13.1 PHOSPHO1 17q21.32 GBM
Fusion : QuiverEIF4A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4A1
dbVarEIF4A1
ClinVarEIF4A1
1000_GenomesEIF4A1 
Exome Variant ServerEIF4A1
ExAC (Exome Aggregation Consortium)ENSG00000161960
GNOMAD BrowserENSG00000161960
Varsome BrowserEIF4A1
Genetic variants : HAPMAP1973
Genomic Variants (DGV)EIF4A1 [DGVbeta]
DECIPHEREIF4A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4A1 
Mutations
ICGC Data PortalEIF4A1 
TCGA Data PortalEIF4A1 
Broad Tumor PortalEIF4A1
OASIS PortalEIF4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4A1
DgiDB (Drug Gene Interaction Database)EIF4A1
DoCM (Curated mutations)EIF4A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4A1 (select a term)
intoGenEIF4A1
Cancer3DEIF4A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602641   
Orphanet
DisGeNETEIF4A1
MedgenEIF4A1
Genetic Testing Registry EIF4A1
NextProtP60842 [Medical]
TSGene1973
GENETestsEIF4A1
Target ValidationEIF4A1
Huge Navigator EIF4A1 [HugePedia]
snp3D : Map Gene to Disease1973
BioCentury BCIQEIF4A1
ClinGenEIF4A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1973
Chemical/Pharm GKB GenePA27710
Clinical trialEIF4A1
Miscellaneous
canSAR (ICR)EIF4A1 (select the gene name)
DataMed IndexEIF4A1
Probes
Litterature
PubMed139 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4A1
EVEXEIF4A1
GoPubMedEIF4A1
iHOPEIF4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:44:52 CET 2019
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