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EIF4A1 (eukaryotic translation initiation factor 4A1)

Identity

Alias (NCBI)DDX2A
EIF-4A
EIF4A
eIF-4A-I
eIF4A-I
HGNC (Hugo) EIF4A1
HGNC Alias symbDDX2A
EIF-4A
HGNC Previous nameEIF4A
HGNC Previous nameeukaryotic translation initiation factor 4A, isoform 1
LocusID (NCBI) 1973
Atlas_Id 46639
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7572825 and ends at 7579006 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTSL (9q21.33) / EIF4A1 (17p13.1)EIF4A1 (17p13.1) / EIF4A1 (17p13.1)EIF4A1 (17p13.1) / HSPA2 (14q23.3)
EIF4A1 (17p13.1) / PHOSPHO1 (17q21.32)FAM120A (9q22.31) / EIF4A1 (17p13.1)NOM1 (7q36.3) / EIF4A1 (17p13.1)
NRF1 (7q32.2) / EIF4A1 (17p13.1)RPL37A (2q35) / EIF4A1 (17p13.1)TMEM223 (11q12.3) / EIF4A1 (17p13.1)
TRAF7 (16p13.3) / EIF4A1 (17p13.1)EIF4A1 17p13.1 / PHOSPHO1 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)EIF4A1   3282
Cards
Entrez_Gene (NCBI)EIF4A1    eukaryotic translation initiation factor 4A1
AliasesDDX2A; EIF-4A; EIF4A; eIF-4A-I; 
eIF4A-I
GeneCards (Weizmann)EIF4A1
Ensembl hg19 (Hinxton)ENSG00000161960 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161960 [Gene_View]  ENSG00000161960 [Sequence]  chr17:7572825-7579006 [Contig_View]  EIF4A1 [Vega]
ICGC DataPortalENSG00000161960
TCGA cBioPortalEIF4A1
AceView (NCBI)EIF4A1
Genatlas (Paris)EIF4A1
SOURCE (Princeton)EIF4A1
Genetics Home Reference (NIH)EIF4A1
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4A1  -     chr17:7572825-7579006 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4A1  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathEIF4A1 - 17p13.1 [CytoView hg19]  EIF4A1 - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000161960
Genome Data Viewer NCBIEIF4A1 [Mapview hg19]  
OMIM602641   
Gene and transcription
Genbank (Entrez)AA446856 AK130082 AK289453 AK291971 AK296664
RefSeq transcript (Entrez)NM_001204510 NM_001416
Consensus coding sequences : CCDS (NCBI)EIF4A1
Gene ExpressionEIF4A1 [ NCBI-GEO ]   EIF4A1 [ EBI - ARRAY_EXPRESS ]   EIF4A1 [ SEEK ]   EIF4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4A1 [ Firebrowse - Broad ]
GenevisibleExpression of EIF4A1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1973
GTEX Portal (Tissue expression)EIF4A1
Human Protein AtlasENSG00000161960-EIF4A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60842   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60842  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60842
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP60842
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)EIF4A1
PDB (RSDB)2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
PDB Europe2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
PDB (PDBSum)2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
PDB (IMB)2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
Structural Biology KnowledgeBase2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
SCOP (Structural Classification of Proteins)2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
CATH (Classification of proteins structures)2G9N    2ZU6    3EIQ    5ZBZ    5ZC9    6ZMW   
SuperfamilyP60842
AlphaFold pdb e-kbP60842   
Human Protein Atlas [tissue]ENSG00000161960-EIF4A1 [tissue]
HPRD04030
Protein Interaction databases
DIP (DOE-UCLA)P60842
IntAct (EBI)P60842
BioGRIDEIF4A1
STRING (EMBL)EIF4A1
ZODIACEIF4A1
Ontologies - Pathways
QuickGOP60842
Ontology : AmiGORNA cap binding  cytoplasmic translational initiation  RNA binding  RNA helicase activity  double-stranded RNA binding  mRNA binding  translation initiation factor activity  helicase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  translational initiation  translation factor activity, RNA binding  membrane  eukaryotic translation initiation factor 4F complex  hydrolase activity  extracellular exosome  
Ontology : EGO-EBIRNA cap binding  cytoplasmic translational initiation  RNA binding  RNA helicase activity  double-stranded RNA binding  mRNA binding  translation initiation factor activity  helicase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  translational initiation  translation factor activity, RNA binding  membrane  eukaryotic translation initiation factor 4F complex  hydrolase activity  extracellular exosome  
Pathways : BIOCARTAInternal Ribosome entry pathway [Genes]    Regulation of eIF4e and p70 S6 Kinase [Genes]    mTOR Signaling Pathway [Genes]    Eukaryotic protein translation [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkEIF4A1
Atlas of Cancer Signalling NetworkEIF4A1
Wikipedia pathwaysEIF4A1
Orthology - Evolution
OrthoDB1973
GeneTree (enSembl)ENSG00000161960
Phylogenetic Trees/Animal Genes : TreeFamEIF4A1
Homologs : HomoloGeneEIF4A1
Homology/Alignments : Family Browser (UCSC)EIF4A1
Gene fusions - Rearrangements
Fusion : MitelmanEIF4A1/PHOSPHO1 [17p13.1/17q21.32]  
Fusion : QuiverEIF4A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4A1
dbVarEIF4A1
ClinVarEIF4A1
MonarchEIF4A1
1000_GenomesEIF4A1 
Exome Variant ServerEIF4A1
GNOMAD BrowserENSG00000161960
Varsome BrowserEIF4A1
ACMGEIF4A1 variants
VarityP60842
Genomic Variants (DGV)EIF4A1 [DGVbeta]
DECIPHEREIF4A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4A1 
Mutations
ICGC Data PortalEIF4A1 
TCGA Data PortalEIF4A1 
Broad Tumor PortalEIF4A1
OASIS PortalEIF4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF4A1
Mutations and Diseases : HGMDEIF4A1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEIF4A1
DgiDB (Drug Gene Interaction Database)EIF4A1
DoCM (Curated mutations)EIF4A1
CIViC (Clinical Interpretations of Variants in Cancer)EIF4A1
Cancer3DEIF4A1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602641   
Orphanet
DisGeNETEIF4A1
MedgenEIF4A1
Genetic Testing Registry EIF4A1
NextProtP60842 [Medical]
GENETestsEIF4A1
Target ValidationEIF4A1
Huge Navigator EIF4A1 [HugePedia]
ClinGenEIF4A1
Clinical trials, drugs, therapy
MyCancerGenomeEIF4A1
Protein Interactions : CTDEIF4A1
Pharm GKB GenePA27710
PharosP60842
Clinical trialEIF4A1
Miscellaneous
canSAR (ICR)EIF4A1
HarmonizomeEIF4A1
DataMed IndexEIF4A1
Probes
Litterature
PubMed208 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEIF4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:55 CEST 2021
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