EIF4A1 (eukaryotic translation initiation factor 4A, isoform 1)

Identity

Other names	DDX2A
	EIF-4A
	EIF4A
HGNC	EIF4A1
Location	17p13
Location_base_pair	Starts at 7416781 and ends at 7423048 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	EIF4A1   3282
Entrez_Gene	EIF4A1  1973  eukaryotic translation initiation factor 4A, isoform 1
	Cards
GeneCards	EIF4A1
Ensembl	EIF4A1 [Search_View]   ENSG00000161960 [Gene_View]
Genatlas	EIF4A1
GeneLynx	EIF4A1
eGenome	EIF4A1
euGene	1973
	Genomic and cartography
GoldenPath	EIF4A1  -  17p13   chr17:7416781-7423048 +  17p13.1   [Description]    (hg18-March_2006)
Ensembl	EIF4A1 - 17p13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EIF4A1
	Gene and transcription
Genbank	AK130082 [ ENTREZ ]
Genbank	AK289453 [ ENTREZ ]
Genbank	AK291971 [ ENTREZ ]
Genbank	AK297916 [ ENTREZ ]
Genbank	AK309274 [ ENTREZ ]
RefSeq	NM_001416 [ SRS ]    NM_001416 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010718 [ SRS ]    NT_010718 [ ENTREZ ]
RefSeq	NW_001838403 [ SRS ]    NW_001838403 [ ENTREZ ]
RefSeq	NW_926584 [ SRS ]    NW_926584 [ ENTREZ ]
AceView	EIF4A1 AceView - NCBI
Unigene	Hs.129673 [ SRS ]    Hs.129673 [ NCBI ]     HS129673 [ spliceNest ]
Fast-db	3117 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P60842 [ SRS]    P60842 [ EXPASY ]     P60842 [ INTERPRO ]     P60842 [ UNIPROT ]
Prosite	PS00039 DEAD_ATP_HELICASE [ SRS ]    PS00039 DEAD_ATP_HELICASE [ Expasy ]
Prosite	PS51192 HELICASE_ATP_BIND_1 [ SRS ]    PS51192 HELICASE_ATP_BIND_1 [ Expasy ]
Prosite	PS51194 HELICASE_CTER [ SRS ]    PS51194 HELICASE_CTER [ Expasy ]
Prosite	PS51195 Q_MOTIF [ SRS ]    PS51195 Q_MOTIF [ Expasy ]
Interpro	IPR014001 DEAD-like_N [ SRS ]    IPR014001 DEAD-like_N [ EBI ]
Interpro	IPR001650 DNA/RNA_helicase_C [ SRS ]    IPR001650 DNA/RNA_helicase_C [ EBI ]
Interpro	IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ SRS ]    IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ EBI ]
Interpro	IPR014021 Helicase_SF1/SF2_ATP-bd [ SRS ]    IPR014021 Helicase_SF1/SF2_ATP-bd [ EBI ]
Interpro	IPR000629 RNA-helicase_DEAD-box_CS [ SRS ]    IPR000629 RNA-helicase_DEAD-box_CS [ EBI ]
Interpro	IPR014014 RNA_helicase_DEAD_Q_motif [ SRS ]    IPR014014 RNA_helicase_DEAD_Q_motif [ EBI ]
CluSTr	P60842
Pfam	PF00270 DEAD [ SRS ]    PF00270 DEAD [ Sanger ]    pfam00270 [ NCBI-CDD ]
Pfam	PF00271 Helicase_C [ SRS ]    PF00271 Helicase_C [ Sanger ]    pfam00271 [ NCBI-CDD ]
Smart	SM00487 DEXDc [EMBL]
Smart	SM00490 HELICc [EMBL]
Blocks	P60842
PDB	2G9N [ SRS ]    2G9N [ PdbSum ],   2G9N [ IMB ]   2G9N [ RSDB ]
HPRD	04030
	Protein Interaction databases
DIP	P60842
IntAct	P60842
	Polymorphism : SNP, mutations, diseases
OMIM	602641    [ map ]
GENECLINICS	602641
SNP	EIF4A1 [dbSNP-NCBI]
SNP	NM_001416 [SNP-NCI]
SNP	EIF4A1 [GeneSNPs - Utah]  EIF4A1] [HGBASE - SRS]
HAPMAP	EIF4A1 [HAPMAP]
COSMIC	EIF4A1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	EIF4A1
	General knowledge
Family Browser	EIF4A1 [UCSC Family Browser]
SOURCE	NM_001416
SMD	Hs.129673
SAGE	Hs.129673
Enzyme	3.6.1.- [ Enzyme-Expasy ]   3.6.1.- [ Enzyme-SRS ]   3.6.1.- [ IntEnz-EBI ]   3.6.1.- [ BRENDA ]   3.6.1.- [ KEGG ]   3.6.1.- [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	RNA cap binding [Amigo]  RNA cap binding
GO	nucleic acid binding [Amigo]  nucleic acid binding
GO	mRNA binding [Amigo]  mRNA binding
GO	translation initiation factor activity [Amigo]  translation initiation factor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytosol [Amigo]  cytosol
GO	translation [Amigo]  translation
GO	ATP-dependent helicase activity [Amigo]  ATP-dependent helicase activity
GO	eukaryotic translation initiation factor 4F complex [Amigo]  eukaryotic translation initiation factor 4F complex
GO	hydrolase activity [Amigo]  hydrolase activity
BIOCARTA	Regulation of eIF4e and p70 S6 Kinase    [Genes]
BIOCARTA	Internal Ribosome entry pathway    [Genes]
BIOCARTA	mTOR Signaling Pathway    [Genes]
PubGene	EIF4A1
TreeFam	EIF4A1
CTD	1973 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EIF4A1 Related clones (RZPD - Berlin)
	PubMed
PubMed	24 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:39:42 2008