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EIF4A3 (eukaryotic translation initiation factor 4A3)

Identity

Alias_namesDDX48
DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
eukaryotic translation initiation factor 4A, isoform 3
Alias_symbol (synonym)KIAA0111
EIF4AIII
Other aliasMUK34
NMP265
NUK34
RCPS
eIF4AIII
HGNC (Hugo) EIF4A3
LocusID (NCBI) 9775
Atlas_Id 46533
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78109013 and ends at 78120982 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK12 (17q12) / EIF4A3 (17q25.3)CHCHD10 (22q11.23) / EIF4A3 (17q25.3)NOM1 (7q36.3) / EIF4A3 (17q25.3)
RAP1A (1p13.2) / EIF4A3 (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF4A3   18683
Cards
Entrez_Gene (NCBI)EIF4A3  9775  eukaryotic translation initiation factor 4A3
AliasesDDX48; MUK34; NMP265; NUK34; 
RCPS; eIF4AIII
GeneCards (Weizmann)EIF4A3
Ensembl hg19 (Hinxton)ENSG00000141543 [Gene_View]  chr17:78109013-78120982 [Contig_View]  EIF4A3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141543 [Gene_View]  chr17:78109013-78120982 [Contig_View]  EIF4A3 [Vega]
ICGC DataPortalENSG00000141543
TCGA cBioPortalEIF4A3
AceView (NCBI)EIF4A3
Genatlas (Paris)EIF4A3
WikiGenes9775
SOURCE (Princeton)EIF4A3
Genetics Home Reference (NIH)EIF4A3
Genomic and cartography
GoldenPath hg19 (UCSC)EIF4A3  -     chr17:78109013-78120982 -  17q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF4A3  -     17q25.3   [Description]    (hg38-Dec_2013)
EnsemblEIF4A3 - 17q25.3 [CytoView hg19]  EIF4A3 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIEIF4A3 [Mapview hg19]  EIF4A3 [Mapview hg38]
OMIM268305   608546   
Gene and transcription
Genbank (Entrez)AK290608 BC003662 BC004386 BC011151 CA428254
RefSeq transcript (Entrez)NM_014740
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)EIF4A3
Cluster EST : UnigeneHs.389649 [ NCBI ]
CGAP (NCI)Hs.389649
Alternative Splicing GalleryENSG00000141543
Gene ExpressionEIF4A3 [ NCBI-GEO ]   EIF4A3 [ EBI - ARRAY_EXPRESS ]   EIF4A3 [ SEEK ]   EIF4A3 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9775
GTEX Portal (Tissue expression)EIF4A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP38919   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP38919  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP38919
Splice isoforms : SwissVarP38919
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusP38919
Domaine pattern : Prosite (Expaxy)DEAD_ATP_HELICASE (PS00039)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    Q_MOTIF (PS51195)   
Domains : Interpro (EBI)DEAD/DEAH_box_helicase_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RNA-helicase_DEAD-box_CS    RNA_helicase_DEAD_Q_motif   
Domain families : Pfam (Sanger)DEAD (PF00270)    Helicase_C (PF00271)   
Domain families : Pfam (NCBI)pfam00270    pfam00271   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)EIF4A3
DMDM Disease mutations9775
Blocks (Seattle)EIF4A3
PDB (SRS)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
PDB (PDBSum)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
PDB (IMB)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
PDB (RSDB)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
Structural Biology KnowledgeBase2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
SCOP (Structural Classification of Proteins)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
CATH (Classification of proteins structures)2HXY    2HYI    2J0Q    2J0S    2J0U    2XB2    3EX7    4C9B   
SuperfamilyP38919
Human Protein AtlasENSG00000141543
Peptide AtlasP38919
HPRD06482
IPIIPI00009328   
Protein Interaction databases
DIP (DOE-UCLA)P38919
IntAct (EBI)P38919
FunCoupENSG00000141543
BioGRIDEIF4A3
STRING (EMBL)EIF4A3
ZODIACEIF4A3
Ontologies - Pathways
QuickGOP38919
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  rRNA processing  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  poly(A) binding  associative learning  RNA splicing  RNA secondary structure unwinding  response to organic cyclic compound  membrane  selenocysteine metabolic process  nuclear speck  negative regulation of translation  dendrite  mRNA 3'-end processing  exon-exon junction complex  selenocysteine insertion sequence binding  RNA stem-loop binding  exploration behavior  ribonucleoprotein complex binding  neuronal cell body  poly(A) RNA binding  positive regulation of translation  embryonic cranial skeleton morphogenesis  catalytic step 2 spliceosome  cellular response to selenite ion  negative regulation of excitatory postsynaptic potential  negative regulation of selenocysteine incorporation  negative regulation of selenocysteine insertion sequence binding  cellular response to brain-derived neurotrophic factor stimulus  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA binding  ATP-dependent RNA helicase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  rRNA processing  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  poly(A) binding  associative learning  RNA splicing  RNA secondary structure unwinding  response to organic cyclic compound  membrane  selenocysteine metabolic process  nuclear speck  negative regulation of translation  dendrite  mRNA 3'-end processing  exon-exon junction complex  selenocysteine insertion sequence binding  RNA stem-loop binding  exploration behavior  ribonucleoprotein complex binding  neuronal cell body  poly(A) RNA binding  positive regulation of translation  embryonic cranial skeleton morphogenesis  catalytic step 2 spliceosome  cellular response to selenite ion  negative regulation of excitatory postsynaptic potential  negative regulation of selenocysteine incorporation  negative regulation of selenocysteine insertion sequence binding  cellular response to brain-derived neurotrophic factor stimulus  
Pathways : KEGGRNA transport    mRNA surveillance pathway    Spliceosome   
NDEx NetworkEIF4A3
Atlas of Cancer Signalling NetworkEIF4A3
Wikipedia pathwaysEIF4A3
Orthology - Evolution
OrthoDB9775
GeneTree (enSembl)ENSG00000141543
Phylogenetic Trees/Animal Genes : TreeFamEIF4A3
HOVERGENP38919
HOGENOMP38919
Homologs : HomoloGeneEIF4A3
Homology/Alignments : Family Browser (UCSC)EIF4A3
Gene fusions - Rearrangements
Fusion : MitelmanCDK12/EIF4A3 [17q12/17q25.3]  [inv(17)(q12q25)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4A3
dbVarEIF4A3
ClinVarEIF4A3
1000_GenomesEIF4A3 
Exome Variant ServerEIF4A3
ExAC (Exome Aggregation Consortium)EIF4A3 (select the gene name)
Genetic variants : HAPMAP9775
Genomic Variants (DGV)EIF4A3 [DGVbeta]
DECIPHER (Syndromes)17:78109013-78120982  ENSG00000141543
CONAN: Copy Number AnalysisEIF4A3 
Mutations
ICGC Data PortalEIF4A3 
TCGA Data PortalEIF4A3 
Broad Tumor PortalEIF4A3
OASIS PortalEIF4A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4A3
DgiDB (Drug Gene Interaction Database)EIF4A3
DoCM (Curated mutations)EIF4A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4A3 (select a term)
intoGenEIF4A3
Cancer3DEIF4A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM268305    608546   
Orphanet2777   
MedgenEIF4A3
Genetic Testing Registry EIF4A3
NextProtP38919 [Medical]
TSGene9775
GENETestsEIF4A3
Huge Navigator EIF4A3 [HugePedia]
snp3D : Map Gene to Disease9775
BioCentury BCIQEIF4A3
ClinGenEIF4A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9775
Chemical/Pharm GKB GenePA162384945
Clinical trialEIF4A3
Miscellaneous
canSAR (ICR)EIF4A3 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4A3
EVEXEIF4A3
GoPubMedEIF4A3
iHOPEIF4A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:55 CEST 2017

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