EIF4E2 (eukaryotic translation initiation factor 4E family member 2)

2012-11-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
4E-LP,4EHP,EIF4EL3,IF4e,h4EHP
FUSION GENES

Other Information

Locus ID:

NCBI: 9470
MIM: 605895
HGNC: 3293
Ensembl: ENSG00000135930

Variants:

dbSNP: 9470
ClinVar: 9470
TCGA: ENSG00000135930
COSMIC: EIF4E2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135930ENST00000258416O60573
ENSG00000135930ENST00000258416Q53RG0
ENSG00000135930ENST00000409098O60573
ENSG00000135930ENST00000409167B4E1E4
ENSG00000135930ENST00000409322B8ZZL3
ENSG00000135930ENST00000409394B9A023
ENSG00000135930ENST00000409495B9A044
ENSG00000135930ENST00000409514B8ZZ50
ENSG00000135930ENST00000444113H7BZH2
ENSG00000135930ENST00000454501C9JEL3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Insulin signaling pathwayKEGGko04910
mTOR signaling pathwayKEGGhsa04150
Insulin signaling pathwayKEGGhsa04910
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
eIF4F complexKEGGM00428
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Longevity regulating pathwayKEGGhsa04211
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172899162007ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.58
227519312012A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.50
284874842017Cap-binding protein 4EHP effects translation silencing by microRNAs.22
173693092007Weak binding affinity of human 4EHP for mRNA cap analogs.21
173684782007Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.20
244089182014Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression.20
210795202011Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.16
263705102015Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs.16
150940422004Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.13

Citation

Dessen P

EIF4E2 (eukaryotic translation initiation factor 4E family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52997/eif4e2