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EIF4E2 (eukaryotic translation initiation factor 4E family member 2)

Identity

Alias_namesEIF4EL3
eukaryotic translation initiation factor 4E-like 3
Alias_symbol (synonym)IF4e
4EHP
Other alias4E-LP
HGNC (Hugo) EIF4E2
LocusID (NCBI) 9470
Atlas_Id 52997
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233415297 and ends at 233448355 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATMIN (16q23.2) / EIF4E2 (2q37.1)EFHD1 (2q37.1) / EIF4E2 (2q37.1)EIF4E2 (2q37.1) / CREBBP (16p13.3)
EIF4E2 (2q37.1) / DIS3L2 (2q37.1)EIF4E2 (2q37.1) / HJURP (2q37.1)EIF4E2 (2q37.1) / LOC100507412 (-)
GIGYF2 (2q37.1) / EIF4E2 (2q37.1)HJURP (2q37.1) / EIF4E2 (2q37.1)TMOD3 (15q21.2) / EIF4E2 (2q37.1)
EFHD1 2q37.1 / EIF4E2 2q37.1EIF4E2 2q37.1 / DIS3L2 2q37.1GIGYF2 2q37.1 / EIF4E2 2q37.1
TMOD3 15q21.2 / EIF4E2 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)EIF4E2   3293
Cards
Entrez_Gene (NCBI)EIF4E2  9470  eukaryotic translation initiation factor 4E family member 2
Aliases4E-LP; 4EHP; EIF4EL3; IF4e
GeneCards (Weizmann)EIF4E2
Ensembl hg19 (Hinxton)ENSG00000135930 [Gene_View]  chr2:233415297-233448355 [Contig_View]  EIF4E2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135930 [Gene_View]  chr2:233415297-233448355 [Contig_View]  EIF4E2 [Vega]
ICGC DataPortalENSG00000135930
TCGA cBioPortalEIF4E2
AceView (NCBI)EIF4E2
Genatlas (Paris)EIF4E2
WikiGenes9470
SOURCE (Princeton)EIF4E2
Genetics Home Reference (NIH)EIF4E2
Genomic and cartography
GoldenPath hg19 (UCSC)EIF4E2  -     chr2:233415297-233448355 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF4E2  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblEIF4E2 - 2q37.1 [CytoView hg19]  EIF4E2 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIEIF4E2 [Mapview hg19]  EIF4E2 [Mapview hg38]
OMIM605895   
Gene and transcription
Genbank (Entrez)AB209519 AF038957 AF047695 AF068117 AK022518
RefSeq transcript (Entrez)NM_001276336 NM_001276337 NM_001282958 NM_004846
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)EIF4E2
Cluster EST : UnigeneHs.292026 [ NCBI ]
CGAP (NCI)Hs.292026
Alternative Splicing GalleryENSG00000135930
Gene ExpressionEIF4E2 [ NCBI-GEO ]   EIF4E2 [ EBI - ARRAY_EXPRESS ]   EIF4E2 [ SEEK ]   EIF4E2 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4E2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9470
GTEX Portal (Tissue expression)EIF4E2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60573   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60573  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60573
Splice isoforms : SwissVarO60573
PhosPhoSitePlusO60573
Domaine pattern : Prosite (Expaxy)IF4E (PS00813)   
Domains : Interpro (EBI)TIF_eIF4e-like    TIF_eIF_4E    TIF_eIF_4E_CS   
Domain families : Pfam (Sanger)IF4E (PF01652)   
Domain families : Pfam (NCBI)pfam01652   
Conserved Domain (NCBI)EIF4E2
DMDM Disease mutations9470
Blocks (Seattle)EIF4E2
PDB (SRS)2JGB    2JGC   
PDB (PDBSum)2JGB    2JGC   
PDB (IMB)2JGB    2JGC   
PDB (RSDB)2JGB    2JGC   
Structural Biology KnowledgeBase2JGB    2JGC   
SCOP (Structural Classification of Proteins)2JGB    2JGC   
CATH (Classification of proteins structures)2JGB    2JGC   
SuperfamilyO60573
Human Protein AtlasENSG00000135930
Peptide AtlasO60573
HPRD05798
IPIIPI00744211   IPI00967202   IPI00556081   IPI00916635   IPI00910085   IPI00917532   IPI00917665   IPI00917207   IPI00917373   IPI00915774   
Protein Interaction databases
DIP (DOE-UCLA)O60573
IntAct (EBI)O60573
FunCoupENSG00000135930
BioGRIDEIF4E2
STRING (EMBL)EIF4E2
ZODIACEIF4E2
Ontologies - Pathways
QuickGOO60573
Ontology : AmiGORNA cap binding  in utero embryonic development  translation initiation factor activity  protein binding  cytosol  mRNA cap binding complex  translational initiation  translation factor activity, RNA binding  negative regulation of translation  ubiquitin protein ligase binding  poly(A) RNA binding  
Ontology : EGO-EBIRNA cap binding  in utero embryonic development  translation initiation factor activity  protein binding  cytosol  mRNA cap binding complex  translational initiation  translation factor activity, RNA binding  negative regulation of translation  ubiquitin protein ligase binding  poly(A) RNA binding  
Pathways : KEGGRNA transport    HIF-1 signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    Insulin signaling pathway   
NDEx NetworkEIF4E2
Atlas of Cancer Signalling NetworkEIF4E2
Wikipedia pathwaysEIF4E2
Orthology - Evolution
OrthoDB9470
GeneTree (enSembl)ENSG00000135930
Phylogenetic Trees/Animal Genes : TreeFamEIF4E2
HOVERGENO60573
HOGENOMO60573
Homologs : HomoloGeneEIF4E2
Homology/Alignments : Family Browser (UCSC)EIF4E2
Gene fusions - Rearrangements
Fusion : MitelmanEFHD1/EIF4E2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanEIF4E2/DIS3L2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanGIGYF2/EIF4E2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanHJURP/EIF4E2 [2q37.1/2q37.1]  [t(2;2)(q37;q37)]  
Fusion : MitelmanTMOD3/EIF4E2 [15q21.2/2q37.1]  [t(2;15)(q37;q21)]  
Fusion: TCGAEFHD1 2q37.1 EIF4E2 2q37.1 BRCA
Fusion: TCGAEIF4E2 2q37.1 DIS3L2 2q37.1 BRCA
Fusion: TCGAGIGYF2 2q37.1 EIF4E2 2q37.1 BRCA
Fusion: TCGATMOD3 15q21.2 EIF4E2 2q37.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4E2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4E2
dbVarEIF4E2
ClinVarEIF4E2
1000_GenomesEIF4E2 
Exome Variant ServerEIF4E2
ExAC (Exome Aggregation Consortium)EIF4E2 (select the gene name)
Genetic variants : HAPMAP9470
Genomic Variants (DGV)EIF4E2 [DGVbeta]
DECIPHER (Syndromes)2:233415297-233448355  ENSG00000135930
CONAN: Copy Number AnalysisEIF4E2 
Mutations
ICGC Data PortalEIF4E2 
TCGA Data PortalEIF4E2 
Broad Tumor PortalEIF4E2
OASIS PortalEIF4E2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4E2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4E2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4E2
DgiDB (Drug Gene Interaction Database)EIF4E2
DoCM (Curated mutations)EIF4E2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4E2 (select a term)
intoGenEIF4E2
Cancer3DEIF4E2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605895   
Orphanet
MedgenEIF4E2
Genetic Testing Registry EIF4E2
NextProtO60573 [Medical]
TSGene9470
GENETestsEIF4E2
Huge Navigator EIF4E2 [HugePedia]
snp3D : Map Gene to Disease9470
BioCentury BCIQEIF4E2
ClinGenEIF4E2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9470
Chemical/Pharm GKB GenePA27720
Clinical trialEIF4E2
Miscellaneous
canSAR (ICR)EIF4E2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4E2
EVEXEIF4E2
GoPubMedEIF4E2
iHOPEIF4E2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:04:29 CET 2017

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