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EIF4E3 (eukaryotic translation initiation factor 4E family member 3)

Identity

Alias_nameseukaryotic translation initiation factor 4E member 3
Alias_symbol (synonym)MGC39820
Other aliaseIF-4E3
eIF4E-3
HGNC (Hugo) EIF4E3
LocusID (NCBI) 317649
Atlas_Id 53621
Location 3p13  [Link to chromosome band 3p13]
Location_base_pair Starts at 71679289 and ends at 71754383 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF4E3 (3p13) / EIF4E3 (3p13)EIF4E3 (3p13) / FCN3 (1p36.11)FOXP1 (3p13) / EIF4E3 (3p13)
PDZRN3 (3p13) / EIF4E3 (3p13)FOXP1 3p13 / EIF4E3 3p13PDZRN3 3p13 / EIF4E3 3p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF4E3   31837
Cards
Entrez_Gene (NCBI)EIF4E3  317649  eukaryotic translation initiation factor 4E family member 3
AliaseseIF-4E3; eIF4E-3
GeneCards (Weizmann)EIF4E3
Ensembl hg19 (Hinxton)ENSG00000163412 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163412 [Gene_View]  chr3:71679289-71754383 [Contig_View]  EIF4E3 [Vega]
ICGC DataPortalENSG00000163412
TCGA cBioPortalEIF4E3
AceView (NCBI)EIF4E3
Genatlas (Paris)EIF4E3
WikiGenes317649
SOURCE (Princeton)EIF4E3
Genetics Home Reference (NIH)EIF4E3
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4E3  -     chr3:71679289-71754383 -  3p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4E3  -     3p13   [Description]    (hg19-Feb_2009)
EnsemblEIF4E3 - 3p13 [CytoView hg19]  EIF4E3 - 3p13 [CytoView hg38]
Mapping of homologs : NCBIEIF4E3 [Mapview hg19]  EIF4E3 [Mapview hg38]
OMIM609896   
Gene and transcription
Genbank (Entrez)AK126999 AK313656 AL161983 BC022303 BC031289
RefSeq transcript (Entrez)NM_001134649 NM_001134650 NM_001134651 NM_001282886 NM_173359
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF4E3
Cluster EST : UnigeneHs.581355 [ NCBI ]
CGAP (NCI)Hs.581355
Alternative Splicing GalleryENSG00000163412
Gene ExpressionEIF4E3 [ NCBI-GEO ]   EIF4E3 [ EBI - ARRAY_EXPRESS ]   EIF4E3 [ SEEK ]   EIF4E3 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4E3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)317649
GTEX Portal (Tissue expression)EIF4E3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N5X7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N5X7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N5X7
Splice isoforms : SwissVarQ8N5X7
PhosPhoSitePlusQ8N5X7
Domains : Interpro (EBI)TIF_eIF4e-like    TIF_eIF_4E   
Domain families : Pfam (Sanger)IF4E (PF01652)   
Domain families : Pfam (NCBI)pfam01652   
Conserved Domain (NCBI)EIF4E3
DMDM Disease mutations317649
Blocks (Seattle)EIF4E3
SuperfamilyQ8N5X7
Human Protein AtlasENSG00000163412
Peptide AtlasQ8N5X7
HPRD10687
IPIIPI00783667   IPI00552764   IPI00945385   IPI00947300   IPI00947118   
Protein Interaction databases
DIP (DOE-UCLA)Q8N5X7
IntAct (EBI)Q8N5X7
FunCoupENSG00000163412
BioGRIDEIF4E3
STRING (EMBL)EIF4E3
ZODIACEIF4E3
Ontologies - Pathways
QuickGOQ8N5X7
Ontology : AmiGOtranslation initiation factor activity  cytosol  mRNA cap binding complex  translational initiation  regulation of translation  
Ontology : EGO-EBItranslation initiation factor activity  cytosol  mRNA cap binding complex  translational initiation  regulation of translation  
NDEx NetworkEIF4E3
Atlas of Cancer Signalling NetworkEIF4E3
Wikipedia pathwaysEIF4E3
Orthology - Evolution
OrthoDB317649
GeneTree (enSembl)ENSG00000163412
Phylogenetic Trees/Animal Genes : TreeFamEIF4E3
HOVERGENQ8N5X7
HOGENOMQ8N5X7
Homologs : HomoloGeneEIF4E3
Homology/Alignments : Family Browser (UCSC)EIF4E3
Gene fusions - Rearrangements
Fusion: TCGAFOXP1 3p13 EIF4E3 3p13 BRCA
Fusion: TCGAPDZRN3 3p13 EIF4E3 3p13 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4E3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4E3
dbVarEIF4E3
ClinVarEIF4E3
1000_GenomesEIF4E3 
Exome Variant ServerEIF4E3
ExAC (Exome Aggregation Consortium)EIF4E3 (select the gene name)
Genetic variants : HAPMAP317649
Genomic Variants (DGV)EIF4E3 [DGVbeta]
DECIPHEREIF4E3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4E3 
Mutations
ICGC Data PortalEIF4E3 
TCGA Data PortalEIF4E3 
Broad Tumor PortalEIF4E3
OASIS PortalEIF4E3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4E3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4E3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4E3
DgiDB (Drug Gene Interaction Database)EIF4E3
DoCM (Curated mutations)EIF4E3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4E3 (select a term)
intoGenEIF4E3
Cancer3DEIF4E3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609896   
Orphanet
MedgenEIF4E3
Genetic Testing Registry EIF4E3
NextProtQ8N5X7 [Medical]
TSGene317649
GENETestsEIF4E3
Target ValidationEIF4E3
Huge Navigator EIF4E3 [HugePedia]
snp3D : Map Gene to Disease317649
BioCentury BCIQEIF4E3
ClinGenEIF4E3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD317649
Chemical/Pharm GKB GenePA134961880
Clinical trialEIF4E3
Miscellaneous
canSAR (ICR)EIF4E3 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4E3
EVEXEIF4E3
GoPubMedEIF4E3
iHOPEIF4E3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:06:43 CEST 2017

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