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EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)

Identity

Alias (NCBI)4EBP2
PHASII
HGNC (Hugo) EIF4EBP2
LocusID (NCBI) 1979
Atlas_Id 51579
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70404145 and ends at 70428618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP83 (12q22) / EIF4EBP2 (10q22.1)EIF4EBP2 (10q22.1) / EIF4EBP2 (10q22.1)EIF4EBP2 (10q22.1) / GSTM1 (1p13.3)
LDHA (11p15.1) / EIF4EBP2 (10q22.1)SERPING1 (11q12.1) / EIF4EBP2 (10q22.1)SSBP3 (1p32.3) / EIF4EBP2 (10q22.1)
TBCB (19q13.12) / EIF4EBP2 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EIF4EBP2   3289
Cards
Entrez_Gene (NCBI)EIF4EBP2    eukaryotic translation initiation factor 4E binding protein 2
Aliases4EBP2; PHASII
GeneCards (Weizmann)EIF4EBP2
Ensembl hg19 (Hinxton)ENSG00000148730 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148730 [Gene_View]  ENSG00000148730 [Sequence]  chr10:70404145-70428618 [Contig_View]  EIF4EBP2 [Vega]
ICGC DataPortalENSG00000148730
TCGA cBioPortalEIF4EBP2
AceView (NCBI)EIF4EBP2
Genatlas (Paris)EIF4EBP2
SOURCE (Princeton)EIF4EBP2
Genetics Home Reference (NIH)EIF4EBP2
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4EBP2  -     chr10:70404145-70428618 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4EBP2  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathEIF4EBP2 - 10q22.1 [CytoView hg19]  EIF4EBP2 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000148730
Genome Data Viewer NCBIEIF4EBP2 [Mapview hg19]  
OMIM602224   
Gene and transcription
Genbank (Entrez)AK001936 AK057643 AK313724 BC005057 BC015007
RefSeq transcript (Entrez)NM_004096
Consensus coding sequences : CCDS (NCBI)EIF4EBP2
Gene ExpressionEIF4EBP2 [ NCBI-GEO ]   EIF4EBP2 [ EBI - ARRAY_EXPRESS ]   EIF4EBP2 [ SEEK ]   EIF4EBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4EBP2 [ Firebrowse - Broad ]
GenevisibleExpression of EIF4EBP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1979
GTEX Portal (Tissue expression)EIF4EBP2
Human Protein AtlasENSG00000148730-EIF4EBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13542   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13542  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13542
PhosPhoSitePlusQ13542
Domains : Interpro (EBI)EIF4EBP   
Domain families : Pfam (Sanger)eIF_4EBP (PF05456)   
Domain families : Pfam (NCBI)pfam05456   
Conserved Domain (NCBI)EIF4EBP2
PDB (RSDB)2MX4    3AM7   
PDB Europe2MX4    3AM7   
PDB (PDBSum)2MX4    3AM7   
PDB (IMB)2MX4    3AM7   
Structural Biology KnowledgeBase2MX4    3AM7   
SCOP (Structural Classification of Proteins)2MX4    3AM7   
CATH (Classification of proteins structures)2MX4    3AM7   
SuperfamilyQ13542
AlphaFold pdb e-kbQ13542   
Human Protein Atlas [tissue]ENSG00000148730-EIF4EBP2 [tissue]
HPRD03747
Protein Interaction databases
DIP (DOE-UCLA)Q13542
IntAct (EBI)Q13542
BioGRIDEIF4EBP2
STRING (EMBL)EIF4EBP2
ZODIACEIF4EBP2
Ontologies - Pathways
QuickGOQ13542
Ontology : AmiGOprotein binding  cytoplasm  translation  memory  eukaryotic initiation factor 4E binding  eukaryotic initiation factor 4E binding  insulin receptor signaling pathway  cAMP-mediated signaling  translation repressor activity  TOR signaling  social behavior  negative regulation of translational initiation  negative regulation of translational initiation  regulation of synaptic plasticity  modulation of chemical synaptic transmission  postsynapse  
Ontology : EGO-EBIprotein binding  cytoplasm  translation  memory  eukaryotic initiation factor 4E binding  eukaryotic initiation factor 4E binding  insulin receptor signaling pathway  cAMP-mediated signaling  translation repressor activity  TOR signaling  social behavior  negative regulation of translational initiation  negative regulation of translational initiation  regulation of synaptic plasticity  modulation of chemical synaptic transmission  postsynapse  
NDEx NetworkEIF4EBP2
Atlas of Cancer Signalling NetworkEIF4EBP2
Wikipedia pathwaysEIF4EBP2
Orthology - Evolution
OrthoDB1979
GeneTree (enSembl)ENSG00000148730
Phylogenetic Trees/Animal Genes : TreeFamEIF4EBP2
Homologs : HomoloGeneEIF4EBP2
Homology/Alignments : Family Browser (UCSC)EIF4EBP2
Gene fusions - Rearrangements
Fusion : QuiverEIF4EBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4EBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4EBP2
dbVarEIF4EBP2
ClinVarEIF4EBP2
MonarchEIF4EBP2
1000_GenomesEIF4EBP2 
Exome Variant ServerEIF4EBP2
GNOMAD BrowserENSG00000148730
Varsome BrowserEIF4EBP2
ACMGEIF4EBP2 variants
VarityQ13542
Genomic Variants (DGV)EIF4EBP2 [DGVbeta]
DECIPHEREIF4EBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4EBP2 
Mutations
ICGC Data PortalEIF4EBP2 
TCGA Data PortalEIF4EBP2 
Broad Tumor PortalEIF4EBP2
OASIS PortalEIF4EBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4EBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF4EBP2
Mutations and Diseases : HGMDEIF4EBP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEIF4EBP2
DgiDB (Drug Gene Interaction Database)EIF4EBP2
DoCM (Curated mutations)EIF4EBP2
CIViC (Clinical Interpretations of Variants in Cancer)EIF4EBP2
Cancer3DEIF4EBP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602224   
Orphanet
DisGeNETEIF4EBP2
MedgenEIF4EBP2
Genetic Testing Registry EIF4EBP2
NextProtQ13542 [Medical]
GENETestsEIF4EBP2
Target ValidationEIF4EBP2
Huge Navigator EIF4EBP2 [HugePedia]
ClinGenEIF4EBP2
Clinical trials, drugs, therapy
MyCancerGenomeEIF4EBP2
Protein Interactions : CTDEIF4EBP2
Pharm GKB GenePA27716
PharosQ13542
Clinical trialEIF4EBP2
Miscellaneous
canSAR (ICR)EIF4EBP2
HarmonizomeEIF4EBP2
DataMed IndexEIF4EBP2
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEIF4EBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:55 CEST 2021

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