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EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3)

Identity

Alias_symbol (synonym)4E-BP3
Other alias4EBP3
HGNC (Hugo) EIF4EBP3
LocusID (NCBI) 8637
Atlas_Id 52256
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 139927251 and ends at 139929163 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKHD1 (5q31.3) / EIF4EBP3 (5q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF4EBP3   3290
Cards
Entrez_Gene (NCBI)EIF4EBP3  8637  eukaryotic translation initiation factor 4E binding protein 3
Aliases4E-BP3; 4EBP3
GeneCards (Weizmann)EIF4EBP3
Ensembl hg19 (Hinxton)ENSG00000243056 [Gene_View]  chr5:139927251-139929163 [Contig_View]  EIF4EBP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000243056 [Gene_View]  chr5:139927251-139929163 [Contig_View]  EIF4EBP3 [Vega]
ICGC DataPortalENSG00000243056
TCGA cBioPortalEIF4EBP3
AceView (NCBI)EIF4EBP3
Genatlas (Paris)EIF4EBP3
WikiGenes8637
SOURCE (Princeton)EIF4EBP3
Genetics Home Reference (NIH)EIF4EBP3
Genomic and cartography
GoldenPath hg19 (UCSC)EIF4EBP3  -     chr5:139927251-139929163 +  5q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF4EBP3  -     5q31.3   [Description]    (hg38-Dec_2013)
EnsemblEIF4EBP3 - 5q31.3 [CytoView hg19]  EIF4EBP3 - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBIEIF4EBP3 [Mapview hg19]  EIF4EBP3 [Mapview hg38]
OMIM603483   
Gene and transcription
Genbank (Entrez)AF038869 BC010881 BC069293 BC073751
RefSeq transcript (Entrez)NM_003732
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)EIF4EBP3
Cluster EST : UnigeneHs.594084 [ NCBI ]
CGAP (NCI)Hs.594084
Alternative Splicing GalleryENSG00000243056
Gene ExpressionEIF4EBP3 [ NCBI-GEO ]   EIF4EBP3 [ EBI - ARRAY_EXPRESS ]   EIF4EBP3 [ SEEK ]   EIF4EBP3 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4EBP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8637
GTEX Portal (Tissue expression)EIF4EBP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60516   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60516  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60516
Splice isoforms : SwissVarO60516
PhosPhoSitePlusO60516
Domains : Interpro (EBI)EIF4EBP   
Domain families : Pfam (Sanger)eIF_4EBP (PF05456)   
Domain families : Pfam (NCBI)pfam05456   
Conserved Domain (NCBI)EIF4EBP3
DMDM Disease mutations8637
Blocks (Seattle)EIF4EBP3
SuperfamilyO60516
Human Protein AtlasENSG00000243056
Peptide AtlasO60516
HPRD09149
IPIIPI00021476   
Protein Interaction databases
DIP (DOE-UCLA)O60516
IntAct (EBI)O60516
FunCoupENSG00000243056
BioGRIDEIF4EBP3
STRING (EMBL)EIF4EBP3
ZODIACEIF4EBP3
Ontologies - Pathways
QuickGOO60516
Ontology : AmiGOprotein binding  cytoplasm  eukaryotic initiation factor 4E binding  membrane  eukaryotic translation initiation factor 4F complex  translation repressor activity  negative regulation of translational initiation  negative regulation of translational initiation  
Ontology : EGO-EBIprotein binding  cytoplasm  eukaryotic initiation factor 4E binding  membrane  eukaryotic translation initiation factor 4F complex  translation repressor activity  negative regulation of translational initiation  negative regulation of translational initiation  
NDEx NetworkEIF4EBP3
Atlas of Cancer Signalling NetworkEIF4EBP3
Wikipedia pathwaysEIF4EBP3
Orthology - Evolution
OrthoDB8637
GeneTree (enSembl)ENSG00000243056
Phylogenetic Trees/Animal Genes : TreeFamEIF4EBP3
HOVERGENO60516
HOGENOMO60516
Homologs : HomoloGeneEIF4EBP3
Homology/Alignments : Family Browser (UCSC)EIF4EBP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4EBP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4EBP3
dbVarEIF4EBP3
ClinVarEIF4EBP3
1000_GenomesEIF4EBP3 
Exome Variant ServerEIF4EBP3
ExAC (Exome Aggregation Consortium)EIF4EBP3 (select the gene name)
Genetic variants : HAPMAP8637
Genomic Variants (DGV)EIF4EBP3 [DGVbeta]
DECIPHER (Syndromes)5:139927251-139929163  ENSG00000243056
CONAN: Copy Number AnalysisEIF4EBP3 
Mutations
ICGC Data PortalEIF4EBP3 
TCGA Data PortalEIF4EBP3 
Broad Tumor PortalEIF4EBP3
OASIS PortalEIF4EBP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4EBP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4EBP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4EBP3
DgiDB (Drug Gene Interaction Database)EIF4EBP3
DoCM (Curated mutations)EIF4EBP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4EBP3 (select a term)
intoGenEIF4EBP3
Cancer3DEIF4EBP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603483   
Orphanet
MedgenEIF4EBP3
Genetic Testing Registry EIF4EBP3
NextProtO60516 [Medical]
TSGene8637
GENETestsEIF4EBP3
Huge Navigator EIF4EBP3 [HugePedia]
snp3D : Map Gene to Disease8637
BioCentury BCIQEIF4EBP3
ClinGenEIF4EBP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8637
Chemical/Pharm GKB GenePA27718
Clinical trialEIF4EBP3
Miscellaneous
canSAR (ICR)EIF4EBP3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4EBP3
EVEXEIF4EBP3
GoPubMedEIF4EBP3
iHOPEIF4EBP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:55 CEST 2017

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