Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

Identity

Alias_namesEIF4G
EIF4F
eukaryotic translation initiation factor 4 gamma
Alias_symbol (synonym)p220
PARK18
Other aliasEIF-4G1
EIF4GI
P220
HGNC (Hugo) EIF4G1
LocusID (NCBI) 1981
Atlas_Id 40433
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184314495 and ends at 184335358 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF4G1 (3q27.1) / ABCC5 (3q27.1)EIF4G1 (3q27.1) / AEBP1 (7p13)EIF4G1 (3q27.1) / EIF4G1 (3q27.1)
EIF4G1 (3q27.1) / HELLS (10q23.33)EIF4G1 (3q27.1) / MCC (5q22.2)EIF4G1 (3q27.1) / SNW1 (14q24.3)
EIF4G1 (3q27.1) / TPM2 (9p13.3)MIR548N (2q31.2) / EIF4G1 (3q27.1)MYO18A (17q11.2) / EIF4G1 (3q27.1)
PPP1R14A (19q13.2) / EIF4G1 (3q27.1)PTMS (12p13.31) / EIF4G1 (3q27.1)RABEP1 (17p13.2) / EIF4G1 (3q27.1)
RAP1A (1p13.2) / EIF4G1 (3q27.1)RNU6-1 () / EIF4G1 (3q27.1)TLN1 (9p13.3) / EIF4G1 (3q27.1)
UCP2 (11q13.4) / EIF4G1 (3q27.1)EIF4G1 3q27.1 / AEBP1 7p13EIF4G1 3q27.1 / SNW1 14q24.3
PTMS 12p13.31 / EIF4G1 3q27.1TLN1 9p13.3 / EIF4G1 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF4G1   3296
Cards
Entrez_Gene (NCBI)EIF4G1  1981  eukaryotic translation initiation factor 4 gamma 1
AliasesEIF-4G1; EIF4F; EIF4G; EIF4GI; 
P220; PARK18
GeneCards (Weizmann)EIF4G1
Ensembl hg19 (Hinxton)ENSG00000114867 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114867 [Gene_View]  chr3:184314495-184335358 [Contig_View]  EIF4G1 [Vega]
ICGC DataPortalENSG00000114867
TCGA cBioPortalEIF4G1
AceView (NCBI)EIF4G1
Genatlas (Paris)EIF4G1
WikiGenes1981
SOURCE (Princeton)EIF4G1
Genetics Home Reference (NIH)EIF4G1
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4G1  -     chr3:184314495-184335358 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4G1  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblEIF4G1 - 3q27.1 [CytoView hg19]  EIF4G1 - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIEIF4G1 [Mapview hg19]  EIF4G1 [Mapview hg38]
OMIM600495   614251   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001194946 NM_001194947 NM_001291157 NM_004953 NM_182917 NM_198241 NM_198242 NM_198244
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF4G1
Cluster EST : UnigeneHs.433750 [ NCBI ]
CGAP (NCI)Hs.433750
Alternative Splicing GalleryENSG00000114867
Gene ExpressionEIF4G1 [ NCBI-GEO ]   EIF4G1 [ EBI - ARRAY_EXPRESS ]   EIF4G1 [ SEEK ]   EIF4G1 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4G1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1981
GTEX Portal (Tissue expression)EIF4G1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04637   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04637  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04637
Splice isoforms : SwissVarQ04637
PhosPhoSitePlusQ04637
Domaine pattern : Prosite (Expaxy)MI (PS51366)    W2 (PS51363)   
Domains : Interpro (EBI)ARM-type_fold    Initiation_fac_eIF4g_MI    MIF4-like    MIF4G-like_typ-3    W2_domain   
Domain families : Pfam (Sanger)MA3 (PF02847)    MIF4G (PF02854)    W2 (PF02020)   
Domain families : Pfam (NCBI)pfam02847    pfam02854    pfam02020   
Domain families : Smart (EMBL)eIF5C (SM00515)  MA3 (SM00544)  MIF4G (SM00543)  
Conserved Domain (NCBI)EIF4G1
DMDM Disease mutations1981
Blocks (Seattle)EIF4G1
PDB (SRS)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
PDB (PDBSum)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
PDB (IMB)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
PDB (RSDB)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
Structural Biology KnowledgeBase1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
SCOP (Structural Classification of Proteins)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
CATH (Classification of proteins structures)1LJ2    1UG3    2W97    4AZA    4F02    5EHC    5EI3    5EIR    5T46   
SuperfamilyQ04637
Human Protein AtlasENSG00000114867
Peptide AtlasQ04637
HPRD06774
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q04637
IntAct (EBI)Q04637
FunCoupENSG00000114867
BioGRIDEIF4G1
STRING (EMBL)EIF4G1
ZODIACEIF4G1
Ontologies - Pathways
QuickGOQ04637
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  behavioral fear response  cap-dependent translational initiation  RNA binding  RNA binding  mRNA binding  translation initiation factor activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  polysome  translation  translation  translational initiation  translational initiation  regulation of translational initiation  regulation of translational initiation  mitochondrion organization  translation factor activity, RNA binding  eukaryotic initiation factor 4E binding  eukaryotic initiation factor 4E binding  positive regulation of cell proliferation  negative regulation of autophagy  negative regulation of peptidyl-threonine phosphorylation  membrane  viral process  eukaryotic translation initiation factor 4F complex  cytosolic small ribosomal subunit  positive regulation of cell growth  translation initiation factor binding  positive regulation of cellular protein metabolic process  developmental process  protein complex scaffold  positive regulation of peptidyl-serine phosphorylation  cellular macromolecule biosynthetic process  regulation of mRNA stability  cadherin binding  positive regulation of neuron differentiation  regulation of gene silencing by miRNA  regulation of cellular response to stress  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of neuron death  positive regulation of eukaryotic translation initiation factor 4F complex assembly  regulation of presynapse assembly  positive regulation of mRNA cap binding  positive regulation of miRNA mediated inhibition of translation  regulation of polysome binding  positive regulation of energy homeostasis  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA poly(A) tail shortening  behavioral fear response  cap-dependent translational initiation  RNA binding  RNA binding  mRNA binding  translation initiation factor activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  polysome  translation  translation  translational initiation  translational initiation  regulation of translational initiation  regulation of translational initiation  mitochondrion organization  translation factor activity, RNA binding  eukaryotic initiation factor 4E binding  eukaryotic initiation factor 4E binding  positive regulation of cell proliferation  negative regulation of autophagy  negative regulation of peptidyl-threonine phosphorylation  membrane  viral process  eukaryotic translation initiation factor 4F complex  cytosolic small ribosomal subunit  positive regulation of cell growth  translation initiation factor binding  positive regulation of cellular protein metabolic process  developmental process  protein complex scaffold  positive regulation of peptidyl-serine phosphorylation  cellular macromolecule biosynthetic process  regulation of mRNA stability  cadherin binding  positive regulation of neuron differentiation  regulation of gene silencing by miRNA  regulation of cellular response to stress  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of neuron death  positive regulation of eukaryotic translation initiation factor 4F complex assembly  regulation of presynapse assembly  positive regulation of mRNA cap binding  positive regulation of miRNA mediated inhibition of translation  regulation of polysome binding  positive regulation of energy homeostasis  
Pathways : BIOCARTAmTOR Signaling Pathway [Genes]    Internal Ribosome entry pathway [Genes]    Regulation of eIF4e and p70 S6 Kinase [Genes]    Eukaryotic protein translation [Genes]   
Pathways : KEGGRNA transport    Viral myocarditis   
NDEx NetworkEIF4G1
Atlas of Cancer Signalling NetworkEIF4G1
Wikipedia pathwaysEIF4G1
Orthology - Evolution
OrthoDB1981
GeneTree (enSembl)ENSG00000114867
Phylogenetic Trees/Animal Genes : TreeFamEIF4G1
HOVERGENQ04637
HOGENOMQ04637
Homologs : HomoloGeneEIF4G1
Homology/Alignments : Family Browser (UCSC)EIF4G1
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G1/ABCC5 [3q27.1/3q27.1]  
Fusion : MitelmanEIF4G1/AEBP1 [3q27.1/7p13]  [t(3;7)(q27;p13)]  
Fusion : MitelmanEIF4G1/SNW1 [3q27.1/14q24.3]  [t(3;14)(q27;q24)]  
Fusion : MitelmanPTMS/EIF4G1 [12p13.31/3q27.1]  [t(3;12)(q27;p13)]  
Fusion : MitelmanTLN1/EIF4G1 [9p13.3/3q27.1]  [t(3;9)(q27;p13)]  
Fusion: TCGAEIF4G1 3q27.1 AEBP1 7p13 SKCM
Fusion: TCGAEIF4G1 3q27.1 SNW1 14q24.3 LUAD
Fusion: TCGAPTMS 12p13.31 EIF4G1 3q27.1 PRAD
Fusion: TCGATLN1 9p13.3 EIF4G1 3q27.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4G1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4G1
dbVarEIF4G1
ClinVarEIF4G1
1000_GenomesEIF4G1 
Exome Variant ServerEIF4G1
ExAC (Exome Aggregation Consortium)EIF4G1 (select the gene name)
Genetic variants : HAPMAP1981
Genomic Variants (DGV)EIF4G1 [DGVbeta]
DECIPHEREIF4G1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4G1 
Mutations
ICGC Data PortalEIF4G1 
TCGA Data PortalEIF4G1 
Broad Tumor PortalEIF4G1
OASIS PortalEIF4G1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4G1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4G1
intOGen PortalEIF4G1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4G1
DgiDB (Drug Gene Interaction Database)EIF4G1
DoCM (Curated mutations)EIF4G1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4G1 (select a term)
intoGenEIF4G1
Cancer3DEIF4G1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600495    614251   
Orphanet23022   
MedgenEIF4G1
Genetic Testing Registry EIF4G1
NextProtQ04637 [Medical]
TSGene1981
GENETestsEIF4G1
Target ValidationEIF4G1
Huge Navigator EIF4G1 [HugePedia]
snp3D : Map Gene to Disease1981
BioCentury BCIQEIF4G1
ClinGenEIF4G1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1981
Chemical/Pharm GKB GenePA27722
Clinical trialEIF4G1
Miscellaneous
canSAR (ICR)EIF4G1 (select the gene name)
Probes
Litterature
PubMed208 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4G1
EVEXEIF4G1
GoPubMedEIF4G1
iHOPEIF4G1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:06:44 CEST 2017

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