EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

2003-02-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
EIF-4G1,EIF4F,EIF4G,EIF4GI,P220,PARK18
FUSION GENES

Other Information

Locus ID:

NCBI: 1981
MIM: 600495
HGNC: 3296
Ensembl: ENSG00000114867

Variants:

dbSNP: 1981
ClinVar: 1981
TCGA: ENSG00000114867
COSMIC: EIF4G1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114867ENST00000342981Q04637
ENSG00000114867ENST00000346169Q04637
ENSG00000114867ENST00000350481Q04637
ENSG00000114867ENST00000352767Q04637
ENSG00000114867ENST00000382330Q04637
ENSG00000114867ENST00000392537Q04637
ENSG00000114867ENST00000411531E7EUU4
ENSG00000114867ENST00000413967F8WB97
ENSG00000114867ENST00000414031Q04637
ENSG00000114867ENST00000421110C9K073
ENSG00000114867ENST00000422614H7C0V6
ENSG00000114867ENST00000424196Q04637
ENSG00000114867ENST00000426123C9JF13
ENSG00000114867ENST00000427141C9J987
ENSG00000114867ENST00000427607C9JSU8
ENSG00000114867ENST00000427845E9PGM1
ENSG00000114867ENST00000428387C9J556
ENSG00000114867ENST00000434061Q04637
ENSG00000114867ENST00000435046Q04637
ENSG00000114867ENST00000440448C9JWH9
ENSG00000114867ENST00000441154E7EX73
ENSG00000114867ENST00000442406F8WCF2
ENSG00000114867ENST00000444134C9JWH7
ENSG00000114867ENST00000444861C9J6B6
ENSG00000114867ENST00000448284H7C044
ENSG00000114867ENST00000450424C9J2Z7
ENSG00000114867ENST00000455679C9JIH5
ENSG00000114867ENST00000456033C9JHW9
ENSG00000114867ENST00000457456C9JWW9

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Viral myocarditisKEGGhsa05416
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
eIF4F complexKEGGM00428
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
mTORC1-mediated signallingREACTOMER-HSA-166208
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNAREACTOMER-HSA-450408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151932582004Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.120
192035802009Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.105
195259342009Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.96
184269772008eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.93
154522232004Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase.86
219070112011Translation initiator EIF4G1 mutations in familial Parkinson disease.84
122392922002Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1.77
167665232006Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.74
182501592008Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.60
185939342008c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.54

Citation

Dessen P

EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40433/eif4g1