Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EIF4G2 (eukaryotic translation initiation factor 4 gamma 2)

Identity

Alias_nameseukaryotic translation initiation factor 4 gamma
Alias_symbol (synonym)DAP5
NAT1
p97
Other aliasAAG1
P97
HGNC (Hugo) EIF4G2
LocusID (NCBI) 1982
Atlas_Id 45619
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 10797046 and ends at 10809035 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APLP2 (11q24.3) / EIF4G2 (11p15.3)EIF4G2 (11p15.3) / APOBEC3C (22q13.1)EIF4G2 (11p15.3) / C5orf45 (5q35.3)
EIF4G2 (11p15.3) / DDX17 (22q13.1)EIF4G2 (11p15.3) / EIF4G2 (11p15.3)EIF4G2 (11p15.3) / FOXK2 (17q25.3)
EIF4G2 (11p15.3) / IFT46 (11q23.3)EIF4G2 (11p15.3) / MFSD14A (1p21.2)EIF4G2 (11p15.3) / NOL4L20q11.21 ()
EIF4G2 (11p15.3) / NUCB2 (11p15.1)EIF4G2 (11p15.3) / SH3GLB2 (9q34.11)EIF4G2 (11p15.3) / STIP1 (11q13.1)
EIF4G2 (11p15.3) / TMEM41B (11p15.4)EIF4G2 (11p15.3) / YWHAG (7q11.23)EIF4G2 (11p15.3) / ZNFX1 (20q13.13)
FAM96A (15q22.31) / EIF4G2 (11p15.3)HECTD1 (14q12) / EIF4G2 (11p15.3)LOC100507412 (-) / EIF4G2 (11p15.3)
MIPOL1 (14q13.3) / EIF4G2 (11p15.3)NBAS (2p24.3) / EIF4G2 (11p15.3)RAB8A (19p13.12) / EIF4G2 (11p15.3)
SELT (3q25.1) / EIF4G2 (11p15.3)SUGP2 (19p13.11) / EIF4G2 (11p15.3)EIF4G2 11p15.3 / C5orf45 5q35.3
EIF4G2 11p15.3 / NUCB2 11p15.1EIF4G2 11p15.3 / ZNFX1 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  EIF4G2/NUCB2 (11p15)
t(11;19)(p15;p13) RAB8A/EIF4G2
t(11;20)(p15;q13) EIF4G2/ZNFX1

External links

Nomenclature
HGNC (Hugo)EIF4G2   3297
Cards
Entrez_Gene (NCBI)EIF4G2  1982  eukaryotic translation initiation factor 4 gamma 2
AliasesAAG1; DAP5; NAT1; P97
GeneCards (Weizmann)EIF4G2
Ensembl hg19 (Hinxton)ENSG00000110321 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110321 [Gene_View]  ENSG00000110321 [Sequence]  chr11:10797046-10809035 [Contig_View]  EIF4G2 [Vega]
ICGC DataPortalENSG00000110321
TCGA cBioPortalEIF4G2
AceView (NCBI)EIF4G2
Genatlas (Paris)EIF4G2
WikiGenes1982
SOURCE (Princeton)EIF4G2
Genetics Home Reference (NIH)EIF4G2
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4G2  -     chr11:10797046-10809035 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4G2  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblEIF4G2 - 11p15.4 [CytoView hg19]  EIF4G2 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIEIF4G2 [Mapview hg19]  EIF4G2 [Mapview hg38]
OMIM602325   
Gene and transcription
Genbank (Entrez)AB063323 AB073654 AB209267 AI362365 AK123338
RefSeq transcript (Entrez)NM_001042559 NM_001172705 NM_001418
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF4G2
Cluster EST : UnigeneHs.183684 [ NCBI ]
CGAP (NCI)Hs.183684
Alternative Splicing GalleryENSG00000110321
Gene ExpressionEIF4G2 [ NCBI-GEO ]   EIF4G2 [ EBI - ARRAY_EXPRESS ]   EIF4G2 [ SEEK ]   EIF4G2 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4G2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1982
GTEX Portal (Tissue expression)EIF4G2
Human Protein AtlasENSG00000110321-EIF4G2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78344
Splice isoforms : SwissVarP78344
PhosPhoSitePlusP78344
Domaine pattern : Prosite (Expaxy)MI (PS51366)    W2 (PS51363)   
Domains : Interpro (EBI)ARM-type_fold    Initiation_fac_eIF4g_MI    MIF4-like_sf    MIF4G-like_typ-3    W2_domain   
Domain families : Pfam (Sanger)MA3 (PF02847)    MIF4G (PF02854)    W2 (PF02020)   
Domain families : Pfam (NCBI)pfam02847    pfam02854    pfam02020   
Domain families : Smart (EMBL)eIF5C (SM00515)  MA3 (SM00544)  MIF4G (SM00543)  
Conserved Domain (NCBI)EIF4G2
DMDM Disease mutations1982
Blocks (Seattle)EIF4G2
PDB (RSDB)3D3M    3L6A    4IUL   
PDB Europe3D3M    3L6A    4IUL   
PDB (PDBSum)3D3M    3L6A    4IUL   
PDB (IMB)3D3M    3L6A    4IUL   
Structural Biology KnowledgeBase3D3M    3L6A    4IUL   
SCOP (Structural Classification of Proteins)3D3M    3L6A    4IUL   
CATH (Classification of proteins structures)3D3M    3L6A    4IUL   
SuperfamilyP78344
Human Protein Atlas [tissue]ENSG00000110321-EIF4G2 [tissue]
Peptide AtlasP78344
HPRD09084
IPIIPI01022651   IPI00782985   IPI00015952   IPI00654814   IPI00976020   IPI00979000   IPI00978458   IPI00983755   IPI00984310   IPI00980508   IPI00985184   IPI00977418   IPI00979033   IPI00979603   IPI00981388   IPI00980818   IPI00976571   IPI00981951   
Protein Interaction databases
DIP (DOE-UCLA)P78344
IntAct (EBI)P78344
FunCoupENSG00000110321
BioGRIDEIF4G2
STRING (EMBL)EIF4G2
ZODIACEIF4G2
Ontologies - Pathways
QuickGOP78344
Ontology : AmiGORNA binding  mRNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  cytosol  cell-cell adherens junction  translational initiation  regulation of translational initiation  cell cycle arrest  translation factor activity, RNA binding  cell death  negative regulation of autophagy  membrane  eukaryotic translation initiation factor 4F complex  eukaryotic translation initiation factor 4F complex  positive regulation of cell growth  cellular macromolecule biosynthetic process  cadherin binding  
Ontology : EGO-EBIRNA binding  mRNA binding  translation initiation factor activity  translation initiation factor activity  protein binding  cytosol  cytosol  cell-cell adherens junction  translational initiation  regulation of translational initiation  cell cycle arrest  translation factor activity, RNA binding  cell death  negative regulation of autophagy  membrane  eukaryotic translation initiation factor 4F complex  eukaryotic translation initiation factor 4F complex  positive regulation of cell growth  cellular macromolecule biosynthetic process  cadherin binding  
Pathways : KEGGRNA transport    Viral myocarditis   
NDEx NetworkEIF4G2
Atlas of Cancer Signalling NetworkEIF4G2
Wikipedia pathwaysEIF4G2
Orthology - Evolution
OrthoDB1982
GeneTree (enSembl)ENSG00000110321
Phylogenetic Trees/Animal Genes : TreeFamEIF4G2
HOGENOMP78344
Homologs : HomoloGeneEIF4G2
Homology/Alignments : Family Browser (UCSC)EIF4G2
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G2/C5orf45 [11p15.3/5q35.3]  
Fusion : MitelmanEIF4G2/NUCB2 [11p15.3/11p15.1]  [t(11;11)(p15;p15)]  
Fusion : MitelmanEIF4G2/ZNFX1 [11p15.3/20q13.13]  [t(11;20)(p15;q13)]  
Fusion : MitelmanRAB8A/EIF4G2 [19p13.12/11p15.3]  [t(11;19)(p15;p13)]  
Fusion PortalEIF4G2 11p15.3 C5orf45 5q35.3 LUAD
Fusion PortalEIF4G2 11p15.3 NUCB2 11p15.1 THCA
Fusion PortalEIF4G2 11p15.3 ZNFX1 20q13.13 LUAD
Fusion Cancer (Beijing)EIF4G2 [11p15.3]  -  C20orf112 [FUSC002492]
Fusion Cancer (Beijing)EIF4G2 [11p15.3]  -  SH3GLB2 [9q34.11]  [FUSC004669]
Fusion : QuiverEIF4G2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4G2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4G2
dbVarEIF4G2
ClinVarEIF4G2
1000_GenomesEIF4G2 
Exome Variant ServerEIF4G2
ExAC (Exome Aggregation Consortium)ENSG00000110321
GNOMAD BrowserENSG00000110321
Varsome BrowserEIF4G2
Genetic variants : HAPMAP1982
Genomic Variants (DGV)EIF4G2 [DGVbeta]
DECIPHEREIF4G2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4G2 
Mutations
ICGC Data PortalEIF4G2 
TCGA Data PortalEIF4G2 
Broad Tumor PortalEIF4G2
OASIS PortalEIF4G2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4G2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4G2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4G2
DgiDB (Drug Gene Interaction Database)EIF4G2
DoCM (Curated mutations)EIF4G2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4G2 (select a term)
intoGenEIF4G2
Cancer3DEIF4G2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602325   
Orphanet
DisGeNETEIF4G2
MedgenEIF4G2
Genetic Testing Registry EIF4G2
NextProtP78344 [Medical]
TSGene1982
GENETestsEIF4G2
Target ValidationEIF4G2
Huge Navigator EIF4G2 [HugePedia]
snp3D : Map Gene to Disease1982
BioCentury BCIQEIF4G2
ClinGenEIF4G2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1982
Chemical/Pharm GKB GenePA27723
Clinical trialEIF4G2
Miscellaneous
canSAR (ICR)EIF4G2 (select the gene name)
DataMed IndexEIF4G2
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4G2
EVEXEIF4G2
GoPubMedEIF4G2
iHOPEIF4G2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:28:46 CET 2019
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