Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EIF4G3 (eukaryotic translation initiation factor 4 gamma 3)


Alias_nameseukaryotic translation initiation factor 4 gamma
Alias_symbol (synonym)eIF4GII
Other aliaseIF-4G 3
eIF4G 3
HGNC (Hugo) EIF4G3
LocusID (NCBI) 8672
Atlas_Id 40434
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 20806292 and ends at 21111383 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP78 (9q21.2) / EIF4G3 (1p36.12)EIF4G3 (1p36.12) / ECE1 (1p36.12)EIF4G3 (1p36.12) / EIF4G3 (1p36.12)
EIF4G3 (1p36.12) / GGA1 (22q13.1)EIF4G3 (1p36.12) / LAPTM4A (2p24.1)EIF4G3 (1p36.12) / LIN28A (1p36.11)
EIF4G3 (1p36.12) / LRRC8D (1p22.2)EIF4G3 (1p36.12) / NSUN4 (1p33)EIF4G3 (1p36.12) / PPP2R3A (3q22.2)
EIF4G3 (1p36.12) / RAP1GAP (1p36.12)EIF4G3 (1p36.12) / SVIP (11p14.3)ENSG00000211894 () / EIF4G3 (1p36.12)
METTL13 (1q24.3) / EIF4G3 (1p36.12)PUM1 (1p35.2) / EIF4G3 (1p36.12)EIF4G3 1p36.12 / ECE1 1p36.12
EIF4G3 1p36.12 / LIN28A 1p36.11EIF4G3 1p36.12 / NSUN4 1p33EIF4G3 1p36.12 / PPP2R3A 3q22.2
EIF4G3 1p36.12 / RAP1GAP 1p36.12METTL13 1q24.3 / EIF4G3 1p36.12PUM1 1p35.2 / EIF4G3 1p36.12


Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(1;1)(p22;p36) EIF4G3/LRRC8D
t(1;1)(p33;p36) EIF4G3/NSUN4
t(1;1)(p35;p36) PUM1/EIF4G3
t(1;1)(p36;p36) EIF4G3/RAP1GAP
t(1;1)(p36;p36) EIF4G3/ECE1
t(1;1)(p36;p36) EIF4G3/LIN28A
t(1;1)(p36;q24) METTL13/EIF4G3
t(1;3)(p36;q22) EIF4G3/PPP2R3A

External links

HGNC (Hugo)EIF4G3   3298
Entrez_Gene (NCBI)EIF4G3  8672  eukaryotic translation initiation factor 4 gamma 3
AliaseseIF-4G; eIF4G; eIF4GII
GeneCards (Weizmann)EIF4G3
Ensembl hg19 (Hinxton)ENSG00000075151 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075151 [Gene_View]  chr1:20806292-21111383 [Contig_View]  EIF4G3 [Vega]
ICGC DataPortalENSG00000075151
TCGA cBioPortalEIF4G3
AceView (NCBI)EIF4G3
Genatlas (Paris)EIF4G3
SOURCE (Princeton)EIF4G3
Genetics Home Reference (NIH)EIF4G3
Genomic and cartography
GoldenPath hg38 (UCSC)EIF4G3  -     chr1:20806292-21111383 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF4G3  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblEIF4G3 - 1p36.12 [CytoView hg19]  EIF4G3 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIEIF4G3 [Mapview hg19]  EIF4G3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB209119 AF012072 AK225489 AK294883 AK302087
RefSeq transcript (Entrez)NM_001198801 NM_001198802 NM_001198803 NM_003760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF4G3
Cluster EST : UnigeneHs.732241 [ NCBI ]
CGAP (NCI)Hs.732241
Alternative Splicing GalleryENSG00000075151
Gene ExpressionEIF4G3 [ NCBI-GEO ]   EIF4G3 [ EBI - ARRAY_EXPRESS ]   EIF4G3 [ SEEK ]   EIF4G3 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF4G3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8672
GTEX Portal (Tissue expression)EIF4G3
Human Protein AtlasENSG00000075151-EIF4G3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43432   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43432  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43432
Splice isoforms : SwissVarO43432
Domaine pattern : Prosite (Expaxy)MI (PS51366)    W2 (PS51363)   
Domains : Interpro (EBI)ARM-type_fold    Initiation_fac_eIF4g_MI    MIF4-like    MIF4G-like_typ-3    W2_domain   
Domain families : Pfam (Sanger)MA3 (PF02847)    MIF4G (PF02854)    W2 (PF02020)   
Domain families : Pfam (NCBI)pfam02847    pfam02854    pfam02020   
Domain families : Smart (EMBL)eIF5C (SM00515)  MA3 (SM00544)  MIF4G (SM00543)  
Conserved Domain (NCBI)EIF4G3
DMDM Disease mutations8672
Blocks (Seattle)EIF4G3
PDB (SRS)1HU3   
PDB (PDBSum)1HU3   
PDB (IMB)1HU3   
Structural Biology KnowledgeBase1HU3   
SCOP (Structural Classification of Proteins)1HU3   
CATH (Classification of proteins structures)1HU3   
Human Protein Atlas [tissue]ENSG00000075151-EIF4G3 [tissue]
Peptide AtlasO43432
IPIIPI00646377   IPI00889701   IPI01014648   IPI01015386   IPI01010928   IPI00328268   IPI00979291   IPI00411710   IPI00514035   IPI00513762   
Protein Interaction databases
IntAct (EBI)O43432
Ontologies - Pathways
Ontology : AmiGORNA cap binding  RNA binding  translation initiation factor activity  cytosol  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  negative regulation of autophagy  viral process  eukaryotic translation initiation factor 4F complex  
Ontology : EGO-EBIRNA cap binding  RNA binding  translation initiation factor activity  cytosol  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  negative regulation of autophagy  viral process  eukaryotic translation initiation factor 4F complex  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    Eukaryotic protein translation [Genes]    mTOR Signaling Pathway [Genes]    Internal Ribosome entry pathway [Genes]   
NDEx NetworkEIF4G3
Atlas of Cancer Signalling NetworkEIF4G3
Wikipedia pathwaysEIF4G3
Orthology - Evolution
GeneTree (enSembl)ENSG00000075151
Phylogenetic Trees/Animal Genes : TreeFamEIF4G3
Homologs : HomoloGeneEIF4G3
Homology/Alignments : Family Browser (UCSC)EIF4G3
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G3/ECE1 [1p36.12/1p36.12]  
Fusion : MitelmanEIF4G3/LIN28A [1p36.12/1p36.11]  [t(1;1)(p36;p36)]  
Fusion : MitelmanEIF4G3/LRRC8D [1p36.12/1p22.2]  [t(1;1)(p22;p36)]  
Fusion : MitelmanEIF4G3/NSUN4 [1p36.12/1p33]  [t(1;1)(p33;p36)]  
Fusion : MitelmanEIF4G3/PPP2R3A [1p36.12/3q22.2]  [t(1;3)(p36;q22)]  
Fusion : MitelmanEIF4G3/RAP1GAP [1p36.12/1p36.12]  [t(1;1)(p36;p36)]  
Fusion : MitelmanMETTL13/EIF4G3 [1q24.3/1p36.12]  [t(1;1)(p36;q24)]  
Fusion : MitelmanPUM1/EIF4G3 [1p35.2/1p36.12]  [t(1;1)(p35;p36)]  
Fusion: TCGA_MDACCEIF4G3 1p36.12 ECE1 1p36.12 LGG LUAD
Fusion: TCGA_MDACCEIF4G3 1p36.12 LIN28A 1p36.11 HNSC
Fusion: TCGA_MDACCEIF4G3 1p36.12 NSUN4 1p33 LUAD
Fusion: TCGA_MDACCEIF4G3 1p36.12 PPP2R3A 3q22.2 BRCA
Fusion: TCGA_MDACCEIF4G3 1p36.12 RAP1GAP 1p36.12 BRCA
Fusion: TCGA_MDACCMETTL13 1q24.3 EIF4G3 1p36.12 PRAD
Fusion: TCGA_MDACCPUM1 1p35.2 EIF4G3 1p36.12 LUSC
Fusion PortalEIF4G3 1p36.12 ECE1 1p36.12 LGG LUAD
Fusion PortalEIF4G3 1p36.12 LIN28A 1p36.11 HNSC
Fusion PortalEIF4G3 1p36.12 NSUN4 1p33 LUAD
Fusion PortalEIF4G3 1p36.12 PPP2R3A 3q22.2 BRCA
Fusion PortalEIF4G3 1p36.12 RAP1GAP 1p36.12 BRCA
Fusion PortalMETTL13 1q24.3 EIF4G3 1p36.12 PRAD
Fusion PortalPUM1 1p35.2 EIF4G3 1p36.12 LUSC
Fusion Cancer (Beijing)ENSG00000211894 [EIF4G3]  -  1p36.12 [FUSC000727]
Fusion : QuiverEIF4G3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF4G3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4G3
Exome Variant ServerEIF4G3
ExAC (Exome Aggregation Consortium)ENSG00000075151
GNOMAD BrowserENSG00000075151
Genetic variants : HAPMAP8672
Genomic Variants (DGV)EIF4G3 [DGVbeta]
DECIPHEREIF4G3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF4G3 
ICGC Data PortalEIF4G3 
TCGA Data PortalEIF4G3 
Broad Tumor PortalEIF4G3
OASIS PortalEIF4G3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF4G3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF4G3
intOGen PortalEIF4G3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4G3
DgiDB (Drug Gene Interaction Database)EIF4G3
DoCM (Curated mutations)EIF4G3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4G3 (select a term)
Cancer3DEIF4G3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry EIF4G3
NextProtO43432 [Medical]
Target ValidationEIF4G3
Huge Navigator EIF4G3 [HugePedia]
snp3D : Map Gene to Disease8672
BioCentury BCIQEIF4G3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8672
Chemical/Pharm GKB GenePA27724
Clinical trialEIF4G3
canSAR (ICR)EIF4G3 (select the gene name)
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:11:02 CET 2018

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