Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EIF4G3 (eukaryotic translation initiation factor 4 gamma, 3)

Identity

Other nameseIF-4G
eIF4G
eIF4GII
HGNC (Hugo) EIF4G3
LocusID (NCBI) 8672
Atlas_Id 40434
Location 1p36.12
Location_base_pair Starts at 21132785 and ends at 21503381 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
EIF4G3 1p36.12 / ECE1 1p36.12EIF4G3 1p36.12 / LIN28A 1p36.11EIF4G3 1p36.12 / NSUN4 1p33
EIF4G3 1p36.12 / PPP2R3A 3q22.2EIF4G3 1p36.12 / RAP1GAP 1p36.12METTL13 1q24.3 / EIF4G3 1p36.12
PUM1 1p35.2 / EIF4G3 1p36.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF4G3   3298
Cards
Entrez_Gene (NCBI)EIF4G3  8672  eukaryotic translation initiation factor 4 gamma, 3
GeneCards (Weizmann)EIF4G3
Ensembl hg19 (Hinxton)ENSG00000075151 [Gene_View]  chr1:21132785-21503381 [Contig_View]  EIF4G3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000075151 [Gene_View]  chr1:21132785-21503381 [Contig_View]  EIF4G3 [Vega]
ICGC DataPortalENSG00000075151
TCGA cBioPortalEIF4G3
AceView (NCBI)EIF4G3
Genatlas (Paris)EIF4G3
WikiGenes8672
SOURCE (Princeton)EIF4G3
Genomic and cartography
GoldenPath hg19 (UCSC)EIF4G3  -     chr1:21132785-21503381 -  1p36.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EIF4G3  -     1p36.12   [Description]    (hg38-Dec_2013)
EnsemblEIF4G3 - 1p36.12 [CytoView hg19]  EIF4G3 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIEIF4G3 [Mapview hg19]  EIF4G3 [Mapview hg38]
OMIM603929   
Gene and transcription
Genbank (Entrez)AB209119 AF012072 AK225489 AK294883 AK302087
RefSeq transcript (Entrez)NM_001198801 NM_001198802 NM_001198803 NM_003760
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)EIF4G3
Cluster EST : UnigeneHs.732241 [ NCBI ]
CGAP (NCI)Hs.732241
Alternative Splicing : Fast-db (Paris)GSHG0001828
Alternative Splicing GalleryENSG00000075151
Gene ExpressionEIF4G3 [ NCBI-GEO ]     EIF4G3 [ SEEK ]   EIF4G3 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8672
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43432 (Uniprot)
NextProtO43432  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43432
Splice isoforms : SwissVarO43432 (Swissvar)
PhosPhoSitePlusO43432
Domaine pattern : Prosite (Expaxy)MI (PS51366)    W2 (PS51363)   
Domains : Interpro (EBI)ARM-type_fold    Initiation_fac_eIF4g_MI    MIF4-like_typ_1/2/3    MIF4G-like_typ-3    W2_domain   
Domain families : Pfam (Sanger)MA3 (PF02847)    MIF4G (PF02854)    W2 (PF02020)   
Domain families : Pfam (NCBI)pfam02847    pfam02854    pfam02020   
Domain families : Smart (EMBL)eIF5C (SM00515)  MA3 (SM00544)  MIF4G (SM00543)  
DMDM Disease mutations8672
Blocks (Seattle)EIF4G3
PDB (SRS)1HU3   
PDB (PDBSum)1HU3   
PDB (IMB)1HU3   
PDB (RSDB)1HU3   
Structural Biology KnowledgeBase1HU3   
SCOP (Structural Classification of Proteins)1HU3   
CATH (Classification of proteins structures)1HU3   
Human Protein AtlasENSG00000075151
Peptide AtlasO43432
HPRD06802
IPIIPI00646377   IPI00889701   IPI01014648   IPI01015386   IPI01010928   IPI00328268   IPI00979291   IPI00411710   IPI00514035   IPI00513762   
Protein Interaction databases
DIP (DOE-UCLA)O43432
IntAct (EBI)O43432
FunCoupENSG00000075151
BioGRIDEIF4G3
IntegromeDBEIF4G3
STRING (EMBL)EIF4G3
ZODIACEIF4G3
Ontologies - Pathways
QuickGOO43432
Ontology : AmiGORNA cap binding  translation initiation factor activity  cytosol  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  viral process  eukaryotic translation initiation factor 4F complex  cytokine-mediated signaling pathway  poly(A) RNA binding  
Ontology : EGO-EBIRNA cap binding  translation initiation factor activity  cytosol  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  viral process  eukaryotic translation initiation factor 4F complex  cytokine-mediated signaling pathway  poly(A) RNA binding  
Pathways : BIOCARTARegulation of eIF4e and p70 S6 Kinase [Genes]    Eukaryotic protein translation [Genes]    mTOR Signaling Pathway [Genes]    Internal Ribosome entry pathway [Genes]   
Pathways : KEGGRNA transport    Viral myocarditis   
Protein Interaction DatabaseEIF4G3
Atlas of Cancer Signalling NetworkEIF4G3
Wikipedia pathwaysEIF4G3
Orthology - Evolution
OrthoDB8672
GeneTree (enSembl)ENSG00000075151
Phylogenetic Trees/Animal Genes : TreeFamEIF4G3
Homologs : HomoloGeneEIF4G3
Homology/Alignments : Family Browser (UCSC)EIF4G3
Gene fusions - Rearrangements
Fusion: TCGAEIF4G3 1p36.12 ECE1 1p36.12 LGG LUAD
Fusion: TCGAEIF4G3 1p36.12 LIN28A 1p36.11 HNSC
Fusion: TCGAEIF4G3 1p36.12 NSUN4 1p33 LUAD
Fusion: TCGAEIF4G3 1p36.12 PPP2R3A 3q22.2 BRCA
Fusion: TCGAEIF4G3 1p36.12 RAP1GAP 1p36.12 BRCA
Fusion: TCGAMETTL13 1q24.3 EIF4G3 1p36.12 PRAD
Fusion: TCGAPUM1 1p35.2 EIF4G3 1p36.12 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerEIF4G3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF4G3
dbVarEIF4G3
ClinVarEIF4G3
1000_GenomesEIF4G3 
Exome Variant ServerEIF4G3
Exome Aggregation Consortium (ExAC)ENSG00000075151
SNP (GeneSNP Utah)EIF4G3
SNP : HGBaseEIF4G3
Genetic variants : HAPMAPEIF4G3
Genomic Variants (DGV)EIF4G3 [DGVbeta]
Mutations
ICGC Data PortalEIF4G3 
TCGA Data PortalEIF4G3 
Tumor PortalEIF4G3
TCGA Copy Number PortalEIF4G3
Somatic Mutations in Cancer : COSMICEIF4G3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF4G3
DgiDB (Drug Gene Interaction Database)EIF4G3
DoCM (Curated mutations)EIF4G3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF4G3 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:21132785-21503381
CONAN: Copy Number AnalysisEIF4G3 
Mutations and Diseases : HGMDEIF4G3
OMIM603929   
MedgenEIF4G3
NextProtO43432 [Medical]
TSGene8672
GENETestsEIF4G3
Huge Navigator EIF4G3 [HugePedia]  EIF4G3 [HugeCancerGEM]
snp3D : Map Gene to Disease8672
BioCentury BCIQEIF4G3
General knowledge
Chemical/Protein Interactions : CTD8672
Chemical/Pharm GKB GenePA27724
Clinical trialEIF4G3
Other databases
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF4G3
GoPubMedEIF4G3
iHOPEIF4G3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jan 16 18:33:18 CET 2016

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