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EIF5 (eukaryotic translation initiation factor 5)

Identity

Other aliasEIF-5
EIF-5A
HGNC (Hugo) EIF5
LocusID (NCBI) 1983
Atlas_Id 62786
Location 14q32.32  [Link to chromosome band 14q32]
Location_base_pair Starts at 103334002 and ends at 103345024 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKIP1 (11p15.4) / EIF5 (14q32.32)EIF5 (14q32.32) / BOP1 (8q24.3)ITPR2 (12p12.1) / EIF5 (14q32.32)
REV1 (2q11.2) / EIF5 (14q32.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF5   3299
Cards
Entrez_Gene (NCBI)EIF5  1983  eukaryotic translation initiation factor 5
AliasesEIF-5; EIF-5A
GeneCards (Weizmann)EIF5
Ensembl hg19 (Hinxton)ENSG00000100664 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100664 [Gene_View]  chr14:103334002-103345024 [Contig_View]  EIF5 [Vega]
ICGC DataPortalENSG00000100664
TCGA cBioPortalEIF5
AceView (NCBI)EIF5
Genatlas (Paris)EIF5
WikiGenes1983
SOURCE (Princeton)EIF5
Genetics Home Reference (NIH)EIF5
Genomic and cartography
GoldenPath hg38 (UCSC)EIF5  -     chr14:103334002-103345024 +  14q32.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF5  -     14q32.32   [Description]    (hg19-Feb_2009)
EnsemblEIF5 - 14q32.32 [CytoView hg19]  EIF5 - 14q32.32 [CytoView hg38]
Mapping of homologs : NCBIEIF5 [Mapview hg19]  EIF5 [Mapview hg38]
OMIM601710   
Gene and transcription
Genbank (Entrez)AK026933 AK027240 AK074470 AK293712 AL080102
RefSeq transcript (Entrez)NM_001969 NM_183004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF5
Cluster EST : UnigeneHs.741278 [ NCBI ]
CGAP (NCI)Hs.741278
Alternative Splicing GalleryENSG00000100664
Gene ExpressionEIF5 [ NCBI-GEO ]   EIF5 [ EBI - ARRAY_EXPRESS ]   EIF5 [ SEEK ]   EIF5 [ MEM ]
Gene Expression Viewer (FireBrowse)EIF5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1983
GTEX Portal (Tissue expression)EIF5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55010   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55010  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55010
Splice isoforms : SwissVarP55010
PhosPhoSitePlusP55010
Domaine pattern : Prosite (Expaxy)W2 (PS51363)   
Domains : Interpro (EBI)ARM-type_fold    MIF4-like    Transl_init_fac_IF2/IF5    Transl_init_fac_IF2/IF5_N    Transl_init_fac_IF2/IF5_Zn-bd    W2_domain   
Domain families : Pfam (Sanger)eIF-5_eIF-2B (PF01873)    W2 (PF02020)   
Domain families : Pfam (NCBI)pfam01873    pfam02020   
Domain families : Smart (EMBL)eIF2B_5 (SM00653)  eIF5C (SM00515)  
Conserved Domain (NCBI)EIF5
DMDM Disease mutations1983
Blocks (Seattle)EIF5
PDB (SRS)2E9H    2G2K    2IU1   
PDB (PDBSum)2E9H    2G2K    2IU1   
PDB (IMB)2E9H    2G2K    2IU1   
PDB (RSDB)2E9H    2G2K    2IU1   
Structural Biology KnowledgeBase2E9H    2G2K    2IU1   
SCOP (Structural Classification of Proteins)2E9H    2G2K    2IU1   
CATH (Classification of proteins structures)2E9H    2G2K    2IU1   
SuperfamilyP55010
Human Protein AtlasENSG00000100664
Peptide AtlasP55010
HPRD03417
IPIIPI00022648   
Protein Interaction databases
DIP (DOE-UCLA)P55010
IntAct (EBI)P55010
FunCoupENSG00000100664
BioGRIDEIF5
STRING (EMBL)EIF5
ZODIACEIF5
Ontologies - Pathways
QuickGOP55010
Ontology : AmiGOformation of translation preinitiation complex  RNA binding  translation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  cadherin binding  eukaryotic initiation factor eIF2 binding  activation of GTPase activity  
Ontology : EGO-EBIformation of translation preinitiation complex  RNA binding  translation initiation factor activity  GTPase activity  protein binding  GTP binding  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  translational initiation  regulation of translational initiation  translation factor activity, RNA binding  cadherin binding  eukaryotic initiation factor eIF2 binding  activation of GTPase activity  
Pathways : BIOCARTARegulation of eIF2 [Genes]    Eukaryotic protein translation [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkEIF5
Atlas of Cancer Signalling NetworkEIF5
Wikipedia pathwaysEIF5
Orthology - Evolution
OrthoDB1983
GeneTree (enSembl)ENSG00000100664
Phylogenetic Trees/Animal Genes : TreeFamEIF5
HOVERGENP55010
HOGENOMP55010
Homologs : HomoloGeneEIF5
Homology/Alignments : Family Browser (UCSC)EIF5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF5
dbVarEIF5
ClinVarEIF5
1000_GenomesEIF5 
Exome Variant ServerEIF5
ExAC (Exome Aggregation Consortium)EIF5 (select the gene name)
Genetic variants : HAPMAP1983
Genomic Variants (DGV)EIF5 [DGVbeta]
DECIPHEREIF5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF5 
Mutations
ICGC Data PortalEIF5 
TCGA Data PortalEIF5 
Broad Tumor PortalEIF5
OASIS PortalEIF5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF5
DgiDB (Drug Gene Interaction Database)EIF5
DoCM (Curated mutations)EIF5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF5 (select a term)
intoGenEIF5
Cancer3DEIF5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601710   
Orphanet
MedgenEIF5
Genetic Testing Registry EIF5
NextProtP55010 [Medical]
TSGene1983
GENETestsEIF5
Huge Navigator EIF5 [HugePedia]
snp3D : Map Gene to Disease1983
BioCentury BCIQEIF5
ClinGenEIF5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1983
Chemical/Pharm GKB GenePA27725
Clinical trialEIF5
Miscellaneous
canSAR (ICR)EIF5 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF5
EVEXEIF5
GoPubMedEIF5
iHOPEIF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:09:37 CEST 2017

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