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EIF5A (eukaryotic translation initiation factor 5A)

Identity

Alias_symbol (synonym)EIF5A1
EIF-5A
MGC99547
MGC104255
Other aliaseIF5AI
HGNC (Hugo) EIF5A
LocusID (NCBI) 1984
Atlas_Id 43812
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7306999 and ends at 7312463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF5A (17p13.1) / ADAR (1q21.3)EIF5A (17p13.1) / DNAJC24 (11p13)EIF5A (17p13.1) / HSF1 (8q24.3)
EIF5A (17p13.1) / RALY (20q11.22)EIF5A (17p13.1) / SGSM3 (22q13.1)FKBP4 (12p13.33) / EIF5A (17p13.1)
FTH1 (11q12.3) / EIF5A (17p13.1)SFPQ (16q24.1) / EIF5A (17p13.1)TCOF1 (5q32) / EIF5A (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF5A   3300
Cards
Entrez_Gene (NCBI)EIF5A  1984  eukaryotic translation initiation factor 5A
AliasesEIF-5A; EIF5A1; eIF5AI
GeneCards (Weizmann)EIF5A
Ensembl hg19 (Hinxton)ENSG00000132507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132507 [Gene_View]  chr17:7306999-7312463 [Contig_View]  EIF5A [Vega]
ICGC DataPortalENSG00000132507
TCGA cBioPortalEIF5A
AceView (NCBI)EIF5A
Genatlas (Paris)EIF5A
WikiGenes1984
SOURCE (Princeton)EIF5A
Genetics Home Reference (NIH)EIF5A
Genomic and cartography
GoldenPath hg38 (UCSC)EIF5A  -     chr17:7306999-7312463 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF5A  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblEIF5A - 17p13.1 [CytoView hg19]  EIF5A - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIEIF5A [Mapview hg19]  EIF5A [Mapview hg38]
OMIM600187   
Gene and transcription
Genbank (Entrez)AF087992 AF376057 AK222585 AK292615 AK303306
RefSeq transcript (Entrez)NM_001143760 NM_001143761 NM_001143762 NM_001970
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF5A
Cluster EST : UnigeneHs.534314 [ NCBI ]
CGAP (NCI)Hs.534314
Alternative Splicing GalleryENSG00000132507
Gene ExpressionEIF5A [ NCBI-GEO ]   EIF5A [ EBI - ARRAY_EXPRESS ]   EIF5A [ SEEK ]   EIF5A [ MEM ]
Gene Expression Viewer (FireBrowse)EIF5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1984
GTEX Portal (Tissue expression)EIF5A
Human Protein AtlasENSG00000132507-EIF5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63241
Splice isoforms : SwissVarP63241
PhosPhoSitePlusP63241
Domaine pattern : Prosite (Expaxy)IF5A_HYPUSINE (PS00302)   
Domains : Interpro (EBI)NA-bd_OB-fold    Rib_L2_dom2    Trans_elong_IF5A_hypusine_site    Transl_elong_IF5A    Transl_elong_IF5A_C    Translation_prot_SH3-like   
Domain families : Pfam (Sanger)eIF-5a (PF01287)   
Domain families : Pfam (NCBI)pfam01287   
Domain families : Smart (EMBL)eIF-5a (SM01376)  
Conserved Domain (NCBI)EIF5A
DMDM Disease mutations1984
Blocks (Seattle)EIF5A
PDB (SRS)1FH4    3CPF    5DLQ   
PDB (PDBSum)1FH4    3CPF    5DLQ   
PDB (IMB)1FH4    3CPF    5DLQ   
PDB (RSDB)1FH4    3CPF    5DLQ   
Structural Biology KnowledgeBase1FH4    3CPF    5DLQ   
SCOP (Structural Classification of Proteins)1FH4    3CPF    5DLQ   
CATH (Classification of proteins structures)1FH4    3CPF    5DLQ   
SuperfamilyP63241
Human Protein Atlas [tissue]ENSG00000132507-EIF5A [tissue]
Peptide AtlasP63241
HPRD02555
IPIIPI00411704   IPI00376005   IPI00921874   IPI00103587   
Protein Interaction databases
DIP (DOE-UCLA)P63241
IntAct (EBI)P63241
FunCoupENSG00000132507
BioGRIDEIF5A
STRING (EMBL)EIF5A
ZODIACEIF5A
Ontologies - Pathways
QuickGOP63241
Ontology : AmiGORNA binding  translation elongation factor activity  protein binding  nucleus  annulate lamellae  nuclear pore  cytoplasm  endoplasmic reticulum membrane  cytosol  mRNA export from nucleus  translational frameshifting  protein export from nucleus  nucleocytoplasmic transport  nucleocytoplasmic transport  apoptotic process  positive regulation of cell proliferation  peptidyl-lysine modification to peptidyl-hypusine  membrane  U6 snRNA binding  ribosome binding  positive regulation of translational elongation  positive regulation of translational termination  protein N-terminus binding  extracellular exosome  
Ontology : EGO-EBIRNA binding  translation elongation factor activity  protein binding  nucleus  annulate lamellae  nuclear pore  cytoplasm  endoplasmic reticulum membrane  cytosol  mRNA export from nucleus  translational frameshifting  protein export from nucleus  nucleocytoplasmic transport  nucleocytoplasmic transport  apoptotic process  positive regulation of cell proliferation  peptidyl-lysine modification to peptidyl-hypusine  membrane  U6 snRNA binding  ribosome binding  positive regulation of translational elongation  positive regulation of translational termination  protein N-terminus binding  extracellular exosome  
NDEx NetworkEIF5A
Atlas of Cancer Signalling NetworkEIF5A
Wikipedia pathwaysEIF5A
Orthology - Evolution
OrthoDB1984
GeneTree (enSembl)ENSG00000132507
Phylogenetic Trees/Animal Genes : TreeFamEIF5A
HOVERGENP63241
HOGENOMP63241
Homologs : HomoloGeneEIF5A
Homology/Alignments : Family Browser (UCSC)EIF5A
Gene fusions - Rearrangements
Fusion : MitelmanFTH1/EIF5A [11q12.3/17p13.1]  [t(11;17)(q12;p13)]  
Fusion: Tumor Portal EIF5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF5A
dbVarEIF5A
ClinVarEIF5A
1000_GenomesEIF5A 
Exome Variant ServerEIF5A
ExAC (Exome Aggregation Consortium)ENSG00000132507
GNOMAD BrowserENSG00000132507
Genetic variants : HAPMAP1984
Genomic Variants (DGV)EIF5A [DGVbeta]
DECIPHEREIF5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF5A 
Mutations
ICGC Data PortalEIF5A 
TCGA Data PortalEIF5A 
Broad Tumor PortalEIF5A
OASIS PortalEIF5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF5A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF5A
DgiDB (Drug Gene Interaction Database)EIF5A
DoCM (Curated mutations)EIF5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF5A (select a term)
intoGenEIF5A
Cancer3DEIF5A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600187   
Orphanet
MedgenEIF5A
Genetic Testing Registry EIF5A
NextProtP63241 [Medical]
TSGene1984
GENETestsEIF5A
Target ValidationEIF5A
Huge Navigator EIF5A [HugePedia]
snp3D : Map Gene to Disease1984
BioCentury BCIQEIF5A
ClinGenEIF5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1984
Chemical/Pharm GKB GenePA27726
Clinical trialEIF5A
Miscellaneous
canSAR (ICR)EIF5A (select the gene name)
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF5A
EVEXEIF5A
GoPubMedEIF5A
iHOPEIF5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:48:36 CET 2017

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