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EIF5A (eukaryotic translation initiation factor 5A)

Identity

Alias (NCBI)EIF-5A
EIF5A1
eIF-4D
eIF5AI
HGNC (Hugo) EIF5A
HGNC Alias symbEIF5A1
EIF-5A
MGC99547
MGC104255
LocusID (NCBI) 1984
Atlas_Id 43812
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7307628 and ends at 7312463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF5A (17p13.1) / ADAR (1q21.3)EIF5A (17p13.1) / DNAJC24 (11p13)EIF5A (17p13.1) / HSF1 (8q24.3)
EIF5A (17p13.1) / RALY (20q11.22)EIF5A (17p13.1) / SGSM3 (22q13.1)FKBP4 (12p13.33) / EIF5A (17p13.1)
FTH1 (11q12.3) / EIF5A (17p13.1)SFPQ (16q24.1) / EIF5A (17p13.1)TCOF1 (5q32) / EIF5A (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EIF5A   3300
Cards
Entrez_Gene (NCBI)EIF5A    eukaryotic translation initiation factor 5A
AliasesEIF-5A; EIF5A1; eIF-4D; eIF5AI
GeneCards (Weizmann)EIF5A
Ensembl hg19 (Hinxton)ENSG00000132507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132507 [Gene_View]  ENSG00000132507 [Sequence]  chr17:7307628-7312463 [Contig_View]  EIF5A [Vega]
ICGC DataPortalENSG00000132507
TCGA cBioPortalEIF5A
AceView (NCBI)EIF5A
Genatlas (Paris)EIF5A
SOURCE (Princeton)EIF5A
Genetics Home Reference (NIH)EIF5A
Genomic and cartography
GoldenPath hg38 (UCSC)EIF5A  -     chr17:7307628-7312463 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF5A  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathEIF5A - 17p13.1 [CytoView hg19]  EIF5A - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000132507
Genome Data Viewer NCBIEIF5A [Mapview hg19]  
OMIM600187   
Gene and transcription
Genbank (Entrez)AF087992 AF376057 AK222585 AK292615 AK303306
RefSeq transcript (Entrez)NM_001143760 NM_001143761 NM_001143762 NM_001370420 NM_001370421 NM_001970
Consensus coding sequences : CCDS (NCBI)EIF5A
Gene ExpressionEIF5A [ NCBI-GEO ]   EIF5A [ EBI - ARRAY_EXPRESS ]   EIF5A [ SEEK ]   EIF5A [ MEM ]
Gene Expression Viewer (FireBrowse)EIF5A [ Firebrowse - Broad ]
GenevisibleExpression of EIF5A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1984
GTEX Portal (Tissue expression)EIF5A
Human Protein AtlasENSG00000132507-EIF5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63241
PhosPhoSitePlusP63241
Domaine pattern : Prosite (Expaxy)IF5A_HYPUSINE (PS00302)   
Domains : Interpro (EBI)IF5A-like    NA-bd_OB-fold    Rib_L2_dom2    Trans_elong_IF5A_hypusine_site    Transl_elong_IF5A_C    Translation_prot_SH3-like_sf   
Domain families : Pfam (Sanger)eIF-5a (PF01287)   
Domain families : Pfam (NCBI)pfam01287   
Domain families : Smart (EMBL)eIF-5a (SM01376)  
Conserved Domain (NCBI)EIF5A
PDB (RSDB)1FH4    3CPF    5DLQ   
PDB Europe1FH4    3CPF    5DLQ   
PDB (PDBSum)1FH4    3CPF    5DLQ   
PDB (IMB)1FH4    3CPF    5DLQ   
Structural Biology KnowledgeBase1FH4    3CPF    5DLQ   
SCOP (Structural Classification of Proteins)1FH4    3CPF    5DLQ   
CATH (Classification of proteins structures)1FH4    3CPF    5DLQ   
SuperfamilyP63241
AlphaFold pdb e-kbP63241   
Human Protein Atlas [tissue]ENSG00000132507-EIF5A [tissue]
HPRD02555
Protein Interaction databases
DIP (DOE-UCLA)P63241
IntAct (EBI)P63241
BioGRIDEIF5A
STRING (EMBL)EIF5A
ZODIACEIF5A
Ontologies - Pathways
QuickGOP63241
Ontology : AmiGORNA binding  RNA binding  translation elongation factor activity  translation elongation factor activity  protein binding  nucleus  annulate lamellae  nuclear pore  cytoplasm  endoplasmic reticulum membrane  cytosol  translational elongation  protein transport  membrane  U6 snRNA binding  tumor necrosis factor-mediated signaling pathway  ribosome binding  positive regulation of translational elongation  positive regulation of translational elongation  positive regulation of translational termination  positive regulation of transcription by RNA polymerase II  protein N-terminus binding  mRNA transport  cellular response to virus  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBIRNA binding  RNA binding  translation elongation factor activity  translation elongation factor activity  protein binding  nucleus  annulate lamellae  nuclear pore  cytoplasm  endoplasmic reticulum membrane  cytosol  translational elongation  protein transport  membrane  U6 snRNA binding  tumor necrosis factor-mediated signaling pathway  ribosome binding  positive regulation of translational elongation  positive regulation of translational elongation  positive regulation of translational termination  positive regulation of transcription by RNA polymerase II  protein N-terminus binding  mRNA transport  cellular response to virus  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
NDEx NetworkEIF5A
Atlas of Cancer Signalling NetworkEIF5A
Wikipedia pathwaysEIF5A
Orthology - Evolution
OrthoDB1984
GeneTree (enSembl)ENSG00000132507
Phylogenetic Trees/Animal Genes : TreeFamEIF5A
Homologs : HomoloGeneEIF5A
Homology/Alignments : Family Browser (UCSC)EIF5A
Gene fusions - Rearrangements
Fusion : MitelmanFTH1/EIF5A [11q12.3/17p13.1]  
Fusion : QuiverEIF5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF5A
dbVarEIF5A
ClinVarEIF5A
MonarchEIF5A
1000_GenomesEIF5A 
Exome Variant ServerEIF5A
GNOMAD BrowserENSG00000132507
Varsome BrowserEIF5A
ACMGEIF5A variants
VarityP63241
Genomic Variants (DGV)EIF5A [DGVbeta]
DECIPHEREIF5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF5A 
Mutations
ICGC Data PortalEIF5A 
TCGA Data PortalEIF5A 
Broad Tumor PortalEIF5A
OASIS PortalEIF5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF5A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEIF5A
Mutations and Diseases : HGMDEIF5A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEIF5A
DgiDB (Drug Gene Interaction Database)EIF5A
DoCM (Curated mutations)EIF5A
CIViC (Clinical Interpretations of Variants in Cancer)EIF5A
Cancer3DEIF5A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600187   
Orphanet
DisGeNETEIF5A
MedgenEIF5A
Genetic Testing Registry EIF5A
NextProtP63241 [Medical]
GENETestsEIF5A
Target ValidationEIF5A
Huge Navigator EIF5A [HugePedia]
ClinGenEIF5A
Clinical trials, drugs, therapy
MyCancerGenomeEIF5A
Protein Interactions : CTDEIF5A
Pharm GKB GenePA27726
PharosP63241
Clinical trialEIF5A
Miscellaneous
canSAR (ICR)EIF5A
HarmonizomeEIF5A
DataMed IndexEIF5A
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEIF5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:57 CEST 2021

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