EIF5A2 (eukaryotic translation initiation factor 5A2)

2003-02-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
EIF-5A2,eIF5AII
FUSION GENES

Other Information

Locus ID:

NCBI: 56648
MIM: 605782
HGNC: 3301
Ensembl: ENSG00000163577

Variants:

dbSNP: 56648
ClinVar: 56648
TCGA: ENSG00000163577
COSMIC: EIF5A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163577ENST00000295822Q9GZV4
ENSG00000163577ENST00000474096F8WCJ1
ENSG00000163577ENST00000474417C9J4W5
ENSG00000163577ENST00000487522C9J7B5

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Hypusine synthesis from eIF5A-lysineREACTOMER-HSA-204626

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218134702012Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition.65
201124252010Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma.58
152053312004Oncogenic role of eIF-5A2 in the development of ovarian cancer.41
111618022001Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.40
146222902003Identification and characterization of eukaryotic initiation factor 5A-2.37
190545482009Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma.33
245612312014Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.33
179497762008Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma.28
257937132015Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer.27
273769582016MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2.27

Citation

Dessen P

EIF5A2 (eukaryotic translation initiation factor 5A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40435/eif5a2