ELA2 (elastase 2, neutrophil)

Identity

Other names	GE
	HLE
	HNE
	NE
	PMN-E
HGNC	ELA2
Location	19p13.3
Location_base_pair	Starts at 803291 and ends at 807246 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ELA2   3309
Entrez_Gene	ELA2  1991  elastase 2, neutrophil
	Cards
GeneCards	ELA2
Ensembl	ELA2 [Search_View]   ENSG00000197561 [Gene_View]
Genatlas	ELA2
GeneLynx	ELA2
eGenome	ELA2
euGene	1991
	Genomic and cartography
GoldenPath	ELA2  -  19p13.3   chr19:803291-807246 +  19p13.3   [Description]    (hg18-March_2006)
Ensembl	ELA2 - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ELA2
	Gene and transcription
Genbank	BC074816 [ ENTREZ ]
Genbank	BC074817 [ ENTREZ ]
Genbank	BI254663 [ ENTREZ ]
Genbank	D00187 [ ENTREZ ]
Genbank	J03545 [ ENTREZ ]
RefSeq	NM_001972 [ SRS ]    NM_001972 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NG_007274 [ SRS ]    NG_007274 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838476 [ SRS ]    NW_001838476 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	ELA2 AceView - NCBI
Unigene	Hs.99863 [ SRS ]    Hs.99863 [ NCBI ]     HS99863 [ spliceNest ]
Fast-db	688 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P08246 [ SRS]    P08246 [ EXPASY ]     P08246 [ INTERPRO ]     P08246 [ UNIPROT ]
Prosite	PS50240 TRYPSIN_DOM [ SRS ]    PS50240 TRYPSIN_DOM [ Expasy ]
Prosite	PS00134 TRYPSIN_HIS [ SRS ]    PS00134 TRYPSIN_HIS [ Expasy ]
Prosite	PS00135 TRYPSIN_SER [ SRS ]    PS00135 TRYPSIN_SER [ Expasy ]
Interpro	IPR001254 Peptidase_S1_S6 [ SRS ]    IPR001254 Peptidase_S1_S6 [ EBI ]
Interpro	IPR001314 Peptidase_S1A [ SRS ]    IPR001314 Peptidase_S1A [ EBI ]
CluSTr	P08246
Pfam	PF00089 Trypsin [ SRS ]    PF00089 Trypsin [ Sanger ]    pfam00089 [ NCBI-CDD ]
Smart	SM00020 Tryp_SPc [EMBL]
Blocks	P08246
PDB	1B0F [ SRS ]    1B0F [ PdbSum ],   1B0F [ IMB ]   1B0F [ RSDB ]
PDB	1H1B [ SRS ]    1H1B [ PdbSum ],   1H1B [ IMB ]   1H1B [ RSDB ]
PDB	1HNE [ SRS ]    1HNE [ PdbSum ],   1HNE [ IMB ]   1HNE [ RSDB ]
PDB	1PPF [ SRS ]    1PPF [ PdbSum ],   1PPF [ IMB ]   1PPF [ RSDB ]
PDB	1PPG [ SRS ]    1PPG [ PdbSum ],   1PPG [ IMB ]   1PPG [ RSDB ]
HPRD	00554
	Protein Interaction databases
DIP	P08246
IntAct	P08246
	Polymorphism : SNP, mutations, diseases
OMIM	130130;162800;202700    [ map ]
GENECLINICS	130130;162800;202700
SNP	ELA2 [dbSNP-NCBI]
SNP	NM_001972 [SNP-NCI]
SNP	ELA2 [GeneSNPs - Utah]  ELA2] [HGBASE - SRS]
HAPMAP	ELA2 [HAPMAP]
HGMD	ELA2
	General knowledge
Family Browser	ELA2 [UCSC Family Browser]
SOURCE	NM_001972
SMD	Hs.99863
SAGE	Hs.99863
Enzyme	3.4.21.37 [ Enzyme-Expasy ]   3.4.21.37 [ Enzyme-SRS ]   3.4.21.37 [ IntEnz-EBI ]   3.4.21.37 [ BRENDA ]   3.4.21.37 [ KEGG ]   3.4.21.37 [ WIT ]
GO	serine-type endopeptidase activity [Amigo]  serine-type endopeptidase activity
GO	extracellular region [Amigo]  extracellular region
GO	proteolysis [Amigo]  proteolysis
GO	cellular calcium ion homeostasis [Amigo]  cellular calcium ion homeostasis
GO	phagocytosis [Amigo]  phagocytosis
GO	peptidase activity [Amigo]  peptidase activity
GO	bacterial binding [Amigo]  bacterial binding
GO	response to UV [Amigo]  response to UV
GO	cell surface [Amigo]  cell surface
GO	cytokine binding [Amigo]  cytokine binding
GO	protein catabolic process [Amigo]  protein catabolic process
GO	elastase activity [Amigo]  elastase activity
GO	positive regulation of MAP kinase activity [Amigo]  positive regulation of MAP kinase activity
GO	negative regulation of chemokine biosynthetic process [Amigo]  negative regulation of chemokine biosynthetic process
GO	negative regulation of interleukin-8 biosynthetic process [Amigo]  negative regulation of interleukin-8 biosynthetic process
GO	positive regulation of interleukin-8 biosynthetic process [Amigo]  positive regulation of interleukin-8 biosynthetic process
GO	positive regulation of smooth muscle cell proliferation [Amigo]  positive regulation of smooth muscle cell proliferation
GO	negative regulation of inflammatory response [Amigo]  negative regulation of inflammatory response
GO	leukocyte migration [Amigo]  leukocyte migration
GO	negative regulation of chemotaxis [Amigo]  negative regulation of chemotaxis
PubGene	ELA2
TreeFam	ELA2
CTD	1991 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ELA2 Related clones (RZPD - Berlin)
	PubMed
PubMed	127 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:39:46 2008