ELF2 (E74 like ETS transcription factor 2)

2007-04-01 Affiliation

Identity

HGNC

ELF2

LOCATION

4q31.1

LOCUSID

1998

ALIAS

EU32,NERF,NERF-1A,NERF-1B,NERF-1a

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1998
HGNC: 3317
Ensembl: ENSG00000109381

Variants:

dbSNP: 1998
ClinVar: 1998
TCGA: ENSG00000109381
COSMIC: ELF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109381	ENST00000358635	Q15723
ENSG00000109381	ENST00000379549	Q15723
ENSG00000109381	ENST00000379550	Q15723
ENSG00000109381	ENST00000394235	Q15723
ENSG00000109381	ENST00000510408	Q15723
ENSG00000109381	ENST00000510408	B7Z720
ENSG00000109381	ENST00000511184	D6RGD9
ENSG00000109381	ENST00000512627	D6RHI1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA316	SLC9A3	Gene	Pathway	associated
PA35928	SLC9A1	Gene	Pathway	associated
PA35929	SLC9A2	Gene	Pathway	associated
PA35930	SLC9A3P1	Gene	Pathway	associated
PA35931	SLC9A3R1	Gene	Pathway	associated
PA35932	SLC9A3R2	Gene	Pathway	associated
PA35933	SLC9A4	Gene	Pathway	associated
PA35934	SLC9A5	Gene	Pathway	associated
PA35935	SLC9A6	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
18754678	2008	The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.	55
28728844	2017	Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.	18
12447867	2002	Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.	12
11967990	2002	NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia.	9
14970218	2004	Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.	8
26968954	2016	ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance.	7
17368566	2007	E74-like factor 2 regulates valosin-containing protein expression.	6
29632131	2018	EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.	6
18544453	2008	E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth.	3

Citation

Dessen P

ELF2 (E74 like ETS transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46993/elf2