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ELF2 (E74 like ETS transcription factor 2)

Identity

Alias_namesE74-like factor 2 (ets domain transcription factor)
Alias_symbol (synonym)EU32
NERF
NERF-2
NERF-1A
NERF-1B
Other aliasNERF-1a,b
HGNC (Hugo) ELF2
LocusID (NCBI) 1998
Atlas_Id 46993
Location 4q31.1  [Link to chromosome band 4q31]
Location_base_pair Starts at 139057717 and ends at 139084414 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF1 (4q21.3) / ELF2 (4q31.1)ELF2 (4q31.1) / KMT2A (11q23.3)ELF2 (4q31.1) / PSMD8 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ELF2   3317
Cards
Entrez_Gene (NCBI)ELF2  1998  E74 like ETS transcription factor 2
AliasesEU32; NERF; NERF-1A; NERF-1B; 
NERF-1a,b; NERF-2
GeneCards (Weizmann)ELF2
Ensembl hg19 (Hinxton)ENSG00000109381 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109381 [Gene_View]  chr4:139057717-139084414 [Contig_View]  ELF2 [Vega]
ICGC DataPortalENSG00000109381
TCGA cBioPortalELF2
AceView (NCBI)ELF2
Genatlas (Paris)ELF2
WikiGenes1998
SOURCE (Princeton)ELF2
Genetics Home Reference (NIH)ELF2
Genomic and cartography
GoldenPath hg38 (UCSC)ELF2  -     chr4:139057717-139084414 -  4q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELF2  -     4q31.1   [Description]    (hg19-Feb_2009)
EnsemblELF2 - 4q31.1 [CytoView hg19]  ELF2 - 4q31.1 [CytoView hg38]
Mapping of homologs : NCBIELF2 [Mapview hg19]  ELF2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF256222 AF256223 AK301307 AK303782 AK311505
RefSeq transcript (Entrez)NM_001276457 NM_001276458 NM_001276459 NM_001331036 NM_006874 NM_201999
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ELF2
Cluster EST : UnigeneHs.634040 [ NCBI ]
CGAP (NCI)Hs.634040
Alternative Splicing GalleryENSG00000109381
Gene ExpressionELF2 [ NCBI-GEO ]   ELF2 [ EBI - ARRAY_EXPRESS ]   ELF2 [ SEEK ]   ELF2 [ MEM ]
Gene Expression Viewer (FireBrowse)ELF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1998
GTEX Portal (Tissue expression)ELF2
Human Protein AtlasENSG00000109381-ELF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15723   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15723  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15723
Splice isoforms : SwissVarQ15723
PhosPhoSitePlusQ15723
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    TF_Elf_N    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Elf-1_N (PF12310)    Ets (PF00178)   
Domain families : Pfam (NCBI)pfam12310    pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELF2
DMDM Disease mutations1998
Blocks (Seattle)ELF2
SuperfamilyQ15723
Human Protein Atlas [tissue]ENSG00000109381-ELF2 [tissue]
Peptide AtlasQ15723
HPRD16856
IPIIPI00009995   IPI00607896   IPI00396265   IPI00607557   IPI00887863   IPI00439925   IPI00966545   IPI00967762   
Protein Interaction databases
DIP (DOE-UCLA)Q15723
IntAct (EBI)Q15723
FunCoupENSG00000109381
BioGRIDELF2
STRING (EMBL)ELF2
ZODIACELF2
Ontologies - Pathways
QuickGOQ15723
Ontology : AmiGORNA polymerase II transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  nuclear body  cell differentiation  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBIRNA polymerase II transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  nuclear body  cell differentiation  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
NDEx NetworkELF2
Atlas of Cancer Signalling NetworkELF2
Wikipedia pathwaysELF2
Orthology - Evolution
OrthoDB1998
GeneTree (enSembl)ENSG00000109381
Phylogenetic Trees/Animal Genes : TreeFamELF2
HOVERGENQ15723
HOGENOMQ15723
Homologs : HomoloGeneELF2
Homology/Alignments : Family Browser (UCSC)ELF2
Gene fusions - Rearrangements
Fusion : MitelmanAFF1/ELF2 [4q21.3/4q31.1]  [ins(11;4)(q23;q21q31)]  
Tumor Fusion PortalELF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELF2
dbVarELF2
ClinVarELF2
1000_GenomesELF2 
Exome Variant ServerELF2
ExAC (Exome Aggregation Consortium)ENSG00000109381
GNOMAD BrowserENSG00000109381
Genetic variants : HAPMAP1998
Genomic Variants (DGV)ELF2 [DGVbeta]
DECIPHERELF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELF2 
Mutations
ICGC Data PortalELF2 
TCGA Data PortalELF2 
Broad Tumor PortalELF2
OASIS PortalELF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDELF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ELF2
DgiDB (Drug Gene Interaction Database)ELF2
DoCM (Curated mutations)ELF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELF2 (select a term)
intoGenELF2
Cancer3DELF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETELF2
MedgenELF2
Genetic Testing Registry ELF2
NextProtQ15723 [Medical]
TSGene1998
GENETestsELF2
Target ValidationELF2
Huge Navigator ELF2 [HugePedia]
snp3D : Map Gene to Disease1998
BioCentury BCIQELF2
ClinGenELF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1998
Chemical/Pharm GKB GenePA27745
Clinical trialELF2
Miscellaneous
canSAR (ICR)ELF2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELF2
EVEXELF2
GoPubMedELF2
iHOPELF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:11:52 CET 2017

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