ELF5 (E74 like ETS transcription factor 5)

2007-04-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
ESE2
FUSION GENES

Other Information

Locus ID:

NCBI: 2001
MIM: 605169
HGNC: 3320
Ensembl: ENSG00000135374

Variants:

dbSNP: 2001
ClinVar: 2001
TCGA: ENSG00000135374
COSMIC: ELF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135374ENST00000257832Q9UKW6
ENSG00000135374ENST00000257832A8K443
ENSG00000135374ENST00000312319Q9UKW6
ENSG00000135374ENST00000429939Q9UKW6
ENSG00000135374ENST00000532417Q9UKW6
ENSG00000135374ENST00000620316A0A087X1W9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917

References

Pubmed IDYearTitleCitations
230862382012Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.104
203540772010ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.58
267174102015ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.17
257283982015Elf5 inhibits TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation.12
167043742006Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2.11
267387402016ELF5 isoform expression is tissue-specific and significantly altered in cancer.9
256297352015Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.6
123596482002DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma.5
162290112006Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor.5
217871132011The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney.5

Citation

Dessen P

ELF5 (E74 like ETS transcription factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46669/elf5