Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ELK1 (ELK1, ETS transcription factor)

Identity

Alias_namesELK1
Other alias-
HGNC (Hugo) ELK1
LocusID (NCBI) 2002
Atlas_Id 40440
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 47635520 and ends at 47650604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELK1 (Xp11.23) / PPOX (1q23.3)WBP2NL (22q13.2) / ELK1 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ELK1   3321
Cards
Entrez_Gene (NCBI)ELK1  2002  ELK1, ETS transcription factor
Aliases
GeneCards (Weizmann)ELK1
Ensembl hg19 (Hinxton)ENSG00000126767 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126767 [Gene_View]  ENSG00000126767 [Sequence]  chrX:47635520-47650604 [Contig_View]  ELK1 [Vega]
ICGC DataPortalENSG00000126767
TCGA cBioPortalELK1
AceView (NCBI)ELK1
Genatlas (Paris)ELK1
WikiGenes2002
SOURCE (Princeton)ELK1
Genetics Home Reference (NIH)ELK1
Genomic and cartography
GoldenPath hg38 (UCSC)ELK1  -     chrX:47635520-47650604 -  Xp11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELK1  -     Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblELK1 - Xp11.23 [CytoView hg19]  ELK1 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBIELK1 [Mapview hg19]  ELK1 [Mapview hg38]
OMIM311040   
Gene and transcription
Genbank (Entrez)AB016193 AB209047 AF000672 AK093966 AK312984
RefSeq transcript (Entrez)NM_001114123 NM_001257168 NM_005229
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ELK1
Cluster EST : UnigeneHs.740673 [ NCBI ]
CGAP (NCI)Hs.740673
Alternative Splicing GalleryENSG00000126767
Gene ExpressionELK1 [ NCBI-GEO ]   ELK1 [ EBI - ARRAY_EXPRESS ]   ELK1 [ SEEK ]   ELK1 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2002
GTEX Portal (Tissue expression)ELK1
Human Protein AtlasENSG00000126767-ELK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19419   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19419  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19419
Splice isoforms : SwissVarP19419
PhosPhoSitePlusP19419
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELK1
DMDM Disease mutations2002
Blocks (Seattle)ELK1
PDB (SRS)1DUX   
PDB (PDBSum)1DUX   
PDB (IMB)1DUX   
PDB (RSDB)1DUX   
Structural Biology KnowledgeBase1DUX   
SCOP (Structural Classification of Proteins)1DUX   
CATH (Classification of proteins structures)1DUX   
SuperfamilyP19419
Human Protein Atlas [tissue]ENSG00000126767-ELK1 [tissue]
Peptide AtlasP19419
HPRD02407
IPIIPI00301527   IPI00220075   IPI01012727   IPI01022186   
Protein Interaction databases
DIP (DOE-UCLA)P19419
IntAct (EBI)P19419
FunCoupENSG00000126767
BioGRIDELK1
STRING (EMBL)ELK1
ZODIACELK1
Ontologies - Pathways
QuickGOP19419
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  chromatin binding  DNA binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  transcription by RNA polymerase II  response to light stimulus  cell differentiation  dendrite  neuronal cell body  axon terminus  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  cellular response to testosterone stimulus  cellular response to gamma radiation  response to fibroblast growth factor  positive regulation of neuron death  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  chromatin binding  DNA binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  transcription by RNA polymerase II  response to light stimulus  cell differentiation  dendrite  neuronal cell body  axon terminus  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  cellular response to testosterone stimulus  cellular response to gamma radiation  response to fibroblast growth factor  positive regulation of neuron death  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    BCR Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Toll-Like Receptor Pathway [Genes]    Signaling Pathway from G-Protein Families [Genes]    Nerve growth factor pathway (NGF) [Genes]    PDGF Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    IGF-1 Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    EGF Signaling Pathway [Genes]    IL 2 signaling pathway [Genes]    IL 6 signaling pathway [Genes]    Insulin Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Ras Signaling Pathway [Genes]   
Pathways : KEGGFocal adhesion    Insulin signaling pathway    MAPK signaling pathway    GnRH signaling pathway   
NDEx NetworkELK1
Atlas of Cancer Signalling NetworkELK1
Wikipedia pathwaysELK1
Orthology - Evolution
OrthoDB2002
GeneTree (enSembl)ENSG00000126767
Phylogenetic Trees/Animal Genes : TreeFamELK1
HOVERGENP19419
HOGENOMP19419
Homologs : HomoloGeneELK1
Homology/Alignments : Family Browser (UCSC)ELK1
Gene fusions - Rearrangements
Fusion : QuiverELK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK1
dbVarELK1
ClinVarELK1
1000_GenomesELK1 
Exome Variant ServerELK1
ExAC (Exome Aggregation Consortium)ENSG00000126767
GNOMAD BrowserENSG00000126767
Genetic variants : HAPMAP2002
Genomic Variants (DGV)ELK1 [DGVbeta]
DECIPHERELK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELK1 
Mutations
ICGC Data PortalELK1 
TCGA Data PortalELK1 
Broad Tumor PortalELK1
OASIS PortalELK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDELK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ELK1
DgiDB (Drug Gene Interaction Database)ELK1
DoCM (Curated mutations)ELK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELK1 (select a term)
intoGenELK1
Cancer3DELK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311040   
Orphanet
DisGeNETELK1
MedgenELK1
Genetic Testing Registry ELK1
NextProtP19419 [Medical]
TSGene2002
GENETestsELK1
Target ValidationELK1
Huge Navigator ELK1 [HugePedia]
snp3D : Map Gene to Disease2002
BioCentury BCIQELK1
ClinGenELK1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2002
Chemical/Pharm GKB GenePA27749
Clinical trialELK1
Miscellaneous
canSAR (ICR)ELK1 (select the gene name)
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELK1
EVEXELK1
GoPubMedELK1
iHOPELK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:24:04 CEST 2018
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