Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ELK1 (ETS transcription factor ELK1)

Identity

Alias (NCBI)-
HGNC (Hugo) ELK1
HGNC Previous nameELK1, member of ETS oncogene family
LocusID (NCBI) 2002
Atlas_Id 40440
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 47635520 and ends at 47650604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELK1 (Xp11.23)::PPOX (1q23.3)WBP2NL (22q13.2)::ELK1 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ELK1   3321
Cards
Entrez_Gene (NCBI)ELK1    ETS transcription factor ELK1
Aliases
GeneCards (Weizmann)ELK1
Ensembl hg19 (Hinxton)ENSG00000126767 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126767 [Gene_View]  ENSG00000126767 [Sequence]  chrX:47635520-47650604 [Contig_View]  ELK1 [Vega]
ICGC DataPortalENSG00000126767
TCGA cBioPortalELK1
AceView (NCBI)ELK1
Genatlas (Paris)ELK1
SOURCE (Princeton)ELK1
Genetics Home Reference (NIH)ELK1
Genomic and cartography
GoldenPath hg38 (UCSC)ELK1  -     chrX:47635520-47650604 -  Xp11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELK1  -     Xp11.23   [Description]    (hg19-Feb_2009)
GoldenPathELK1 - Xp11.23 [CytoView hg19]  ELK1 - Xp11.23 [CytoView hg38]
ImmunoBaseENSG00000126767
Genome Data Viewer NCBIELK1 [Mapview hg19]  
OMIM311040   
Gene and transcription
Genbank (Entrez)AB016193 AB209047 AF000672 AK093966 AK312984
RefSeq transcript (Entrez)NM_001114123 NM_001257168 NM_005229
Consensus coding sequences : CCDS (NCBI)ELK1
Gene ExpressionELK1 [ NCBI-GEO ]   ELK1 [ EBI - ARRAY_EXPRESS ]   ELK1 [ SEEK ]   ELK1 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK1 [ Firebrowse - Broad ]
GenevisibleExpression of ELK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2002
GTEX Portal (Tissue expression)ELK1
Human Protein AtlasENSG00000126767-ELK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19419   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19419  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19419
PhosPhoSitePlusP19419
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELK1
PDB (RSDB)1DUX    5VVT   
PDB Europe1DUX    5VVT   
PDB (PDBSum)1DUX    5VVT   
PDB (IMB)1DUX    5VVT   
Structural Biology KnowledgeBase1DUX    5VVT   
SCOP (Structural Classification of Proteins)1DUX    5VVT   
CATH (Classification of proteins structures)1DUX    5VVT   
SuperfamilyP19419
AlphaFold pdb e-kbP19419   
Human Protein Atlas [tissue]ENSG00000126767-ELK1 [tissue]
HPRD02407
Protein Interaction databases
DIP (DOE-UCLA)P19419
IntAct (EBI)P19419
BioGRIDELK1
STRING (EMBL)ELK1
ZODIACELK1
Ontologies - Pathways
QuickGOP19419
Ontology : AmiGOchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  regulation of transcription by RNA polymerase II  response to light stimulus  gene expression  cell differentiation  lung development  nuclear receptor coactivator activity  dendrite  neuronal cell body  axon terminus  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  RNA polymerase II-specific DNA-binding transcription factor binding  cellular response to testosterone stimulus  cellular response to gamma radiation  response to fibroblast growth factor  positive regulation of neuron death  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  liver development  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  regulation of transcription by RNA polymerase II  response to light stimulus  gene expression  cell differentiation  lung development  nuclear receptor coactivator activity  dendrite  neuronal cell body  axon terminus  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  RNA polymerase II-specific DNA-binding transcription factor binding  cellular response to testosterone stimulus  cellular response to gamma radiation  response to fibroblast growth factor  positive regulation of neuron death  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTABIOCARTA_AT1RPATHWAY    BIOCARTA_BCRPATHWAY    BIOCARTA_EGFPATHWAY    BIOCARTA_EPOPATHWAY    BIOCARTA_ERKPATHWAY    BIOCARTA_FCER1PATHWAY    BIOCARTA_FMLPPATHWAY    BIOCARTA_IGF1PATHWAY    BIOCARTA_IL2PATHWAY    BIOCARTA_IL6PATHWAY    BIOCARTA_INSULINPATHWAY    BIOCARTA_MAPKPATHWAY    BIOCARTA_NGFPATHWAY    BIOCARTA_P38MAPKPATHWAY    BIOCARTA_PDGFPATHWAY    BIOCARTA_RASPATHWAY    BIOCARTA_METPATHWAY    BIOCARTA_GPCRPATHWAY    BIOCARTA_TCRPATHWAY    BIOCARTA_TOLLPATHWAY   
Pathways : KEGGKEGG_MAPK_SIGNALING    KEGG_ERBB_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_INSULIN_SIGNALING    KEGG_GNRH_SIGNALING    KEGG_PRION_DISEASES    KEGG_LEISHMANIA_INFECTION    KEGG_ENDOMETRIAL_CANCER   
NDEx NetworkELK1
Atlas of Cancer Signalling NetworkELK1
Wikipedia pathwaysELK1
Orthology - Evolution
OrthoDB2002
GeneTree (enSembl)ENSG00000126767
Phylogenetic Trees/Animal Genes : TreeFamELK1
Homologs : HomoloGeneELK1
Homology/Alignments : Family Browser (UCSC)ELK1
Gene fusions - Rearrangements
Fusion : QuiverELK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK1
dbVarELK1
ClinVarELK1
MonarchELK1
1000_GenomesELK1 
Exome Variant ServerELK1
GNOMAD BrowserENSG00000126767
Varsome BrowserELK1
ACMGELK1 variants
VarityP19419
Genomic Variants (DGV)ELK1 [DGVbeta]
DECIPHERELK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELK1 
Mutations
ICGC Data PortalELK1 
TCGA Data PortalELK1 
Broad Tumor PortalELK1
OASIS PortalELK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DELK1
Mutations and Diseases : HGMDELK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaELK1
DgiDB (Drug Gene Interaction Database)ELK1
DoCM (Curated mutations)ELK1
CIViC (Clinical Interpretations of Variants in Cancer)ELK1
Cancer3DELK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311040   
Orphanet
DisGeNETELK1
MedgenELK1
Genetic Testing Registry ELK1
NextProtP19419 [Medical]
GENETestsELK1
Target ValidationELK1
Huge Navigator ELK1 [HugePedia]
ClinGenELK1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeELK1
Protein Interactions : CTDELK1
Pharm GKB GenePA27749
Pharm GKB PathwaysPA162356267   
PharosP19419
Clinical trialELK1
Miscellaneous
canSAR (ICR)ELK1
HarmonizomeELK1
ARCHS4ELK1
DataMed IndexELK1
Probes
Litterature
PubMed225 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXELK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:31:58 CET 2022

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