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ELK3 (ELK3, ETS-domain protein (SRF accessory protein 2))

Identity

Other namesERP
NET
SAP-2
SAP2
HGNC (Hugo) ELK3
LocusID (NCBI) 2004
Atlas_Id 40443
Location 12q23.1
Location_base_pair Starts at 96649238 and ends at 96663613 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ELK3   3325
Cards
Entrez_Gene (NCBI)ELK3  2004  ELK3, ETS-domain protein (SRF accessory protein 2)
GeneCards (Weizmann)ELK3
Ensembl hg19 (Hinxton)ENSG00000111145 [Gene_View]  chr12:96649238-96663613 [Contig_View]  ELK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111145 [Gene_View]  chr12:96649238-96663613 [Contig_View]  ELK3 [Vega]
ICGC DataPortalENSG00000111145
TCGA cBioPortalELK3
AceView (NCBI)ELK3
Genatlas (Paris)ELK3
WikiGenes2004
SOURCE (Princeton)ELK3
Genomic and cartography
GoldenPath hg19 (UCSC)ELK3  -     chr12:96649238-96663613 +  12q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ELK3  -     12q23.1   [Description]    (hg38-Dec_2013)
EnsemblELK3 - 12q23.1 [CytoView hg19]  ELK3 - 12q23.1 [CytoView hg38]
Mapping of homologs : NCBIELK3 [Mapview hg19]  ELK3 [Mapview hg38]
OMIM600247   
Gene and transcription
Genbank (Entrez)AK026078 AK312694 AL705041 AW575797 BC017371
RefSeq transcript (Entrez)NM_001303511 NM_005230
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)ELK3
Cluster EST : UnigeneHs.718709 [ NCBI ]
CGAP (NCI)Hs.718709
Alternative Splicing : Fast-db (Paris)GSHG0006917
Alternative Splicing GalleryENSG00000111145
Gene ExpressionELK3 [ NCBI-GEO ]     ELK3 [ SEEK ]   ELK3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41970 (Uniprot)
NextProtP41970  [Medical]
With graphics : InterProP41970
Splice isoforms : SwissVarP41970 (Swissvar)
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WHTH_DNA-bd_dom   
Related proteins : CluSTrP41970
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
DMDM Disease mutations2004
Blocks (Seattle)P41970
Human Protein AtlasENSG00000111145
Peptide AtlasP41970
HPRD02593
IPIIPI00018266   IPI01021365   IPI01021116   IPI01022259   IPI01022077   
Protein Interaction databases
DIP (DOE-UCLA)P41970
IntAct (EBI)P41970
FunCoupENSG00000111145
BioGRIDELK3
IntegromeDBELK3
STRING (EMBL)ELK3
Ontologies - Pathways
QuickGOP41970
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  sequence-specific DNA binding RNA polymerase II transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  angiogenesis  sequence-specific DNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  mitochondrion  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  sequence-specific DNA binding RNA polymerase II transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  angiogenesis  sequence-specific DNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  mitochondrion  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
Protein Interaction DatabaseELK3
DoCM (Curated mutations)ELK3
Wikipedia pathwaysELK3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerELK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK3
dbVarELK3
ClinVarELK3
1000_GenomesELK3 
Exome Variant ServerELK3
SNP (GeneSNP Utah)ELK3
SNP : HGBaseELK3
Genetic variants : HAPMAPELK3
Genomic Variants (DGV)ELK3 [DGVbeta]
Mutations
ICGC Data PortalELK3 
TCGA Data PortalELK3 
Tumor PortalELK3
Somatic Mutations in Cancer : COSMICELK3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:96649238-96663613
CONAN: Copy Number AnalysisELK3 
Mutations and Diseases : HGMDELK3
OMIM600247   
MedgenELK3
NextProtP41970 [Medical]
GENETestsELK3
Disease Genetic AssociationELK3
Huge Navigator ELK3 [HugePedia]  ELK3 [HugeCancerGEM]
snp3D : Map Gene to Disease2004
DGIdb (Drug Gene Interaction db)ELK3
General knowledge
Homologs : HomoloGeneELK3
Homology/Alignments : Family Browser (UCSC)ELK3
Phylogenetic Trees/Animal Genes : TreeFamELK3
Chemical/Protein Interactions : CTD2004
Chemical/Pharm GKB GenePA27752
Clinical trialELK3
Cancer Resource (Charite)ENSG00000111145
Other databases
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
CoreMineELK3
GoPubMedELK3
iHOPELK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:22:34 CEST 2015

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