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ELK3 (ELK3, ETS transcription factor)

Identity

Other namesERP
NET
SAP-2
SAP2
HGNC (Hugo) ELK3
LocusID (NCBI) 2004
Atlas_Id 40443
Location 12q23.1
Location_base_pair Starts at 96649238 and ends at 96663613 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AES (19p13.3) / ELK3 (12q23.1)C3 (19p13.3) / ELK3 (12q23.1)COL4A1 (13q34) / ELK3 (12q23.1)
COL4A2 (13q34) / ELK3 (12q23.1)COL6A2 (21q22.3) / ELK3 (12q23.1)COL9A3 (20q13.33) / ELK3 (12q23.1)
ELK3 (12q23.1) / AMDHD1 (12q23.1)LGALS3BP (17q25.3) / ELK3 (12q23.1)SFN (1p36.11) / ELK3 (12q23.1)
AES 19p13.3 / ELK3 12q23.1C3 19p13.3 / ELK3 12q23.1COL4A1 13q34 / ELK3 12q23.1
COL4A2 13q34 / ELK3 12q23.1COL6A2 21q22.3 / ELK3 12q23.1COL9A3 20q13.33 / ELK3 12q23.1
ELK3 12q23.1 / AMDHD1 12q23.1LGALS3BP 17q25.3 / ELK3 12q23.1SFN 1p36.11 / ELK3 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ELK3   3325
Cards
Entrez_Gene (NCBI)ELK3  2004  ELK3, ETS transcription factor
AliasesERP; NET; SAP-2; SAP2
GeneCards (Weizmann)ELK3
Ensembl hg19 (Hinxton)ENSG00000111145 [Gene_View]  chr12:96649238-96663613 [Contig_View]  ELK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111145 [Gene_View]  chr12:96649238-96663613 [Contig_View]  ELK3 [Vega]
ICGC DataPortalENSG00000111145
TCGA cBioPortalELK3
AceView (NCBI)ELK3
Genatlas (Paris)ELK3
WikiGenes2004
SOURCE (Princeton)ELK3
Genomic and cartography
GoldenPath hg19 (UCSC)ELK3  -     chr12:96649238-96663613 +  12q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ELK3  -     12q23.1   [Description]    (hg38-Dec_2013)
EnsemblELK3 - 12q23.1 [CytoView hg19]  ELK3 - 12q23.1 [CytoView hg38]
Mapping of homologs : NCBIELK3 [Mapview hg19]  ELK3 [Mapview hg38]
OMIM600247   
Gene and transcription
Genbank (Entrez)AK026078 AK312694 AL705041 AW575797 BC017371
RefSeq transcript (Entrez)NM_001303511 NM_005230
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)ELK3
Cluster EST : UnigeneHs.718709 [ NCBI ]
CGAP (NCI)Hs.718709
Alternative Splicing GalleryENSG00000111145
Gene ExpressionELK3 [ NCBI-GEO ]   ELK3 [ EBI - ARRAY_EXPRESS ]   ELK3 [ SEEK ]   ELK3 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2004
GTEX Portal (Tissue expression)ELK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41970 (Uniprot)
NextProtP41970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41970
Splice isoforms : SwissVarP41970 (Swissvar)
PhosPhoSitePlusP41970
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
DMDM Disease mutations2004
Blocks (Seattle)ELK3
SuperfamilyP41970
Human Protein AtlasENSG00000111145
Peptide AtlasP41970
HPRD02593
IPIIPI00018266   IPI01021365   IPI01021116   IPI01022259   IPI01022077   
Protein Interaction databases
DIP (DOE-UCLA)P41970
IntAct (EBI)P41970
FunCoupENSG00000111145
BioGRIDELK3
STRING (EMBL)ELK3
ZODIACELK3
Ontologies - Pathways
QuickGOP41970
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  transcription from RNA polymerase II promoter  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  angiogenesis  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  transcription from RNA polymerase II promoter  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  
NDEx Network
Atlas of Cancer Signalling NetworkELK3
Wikipedia pathwaysELK3
Orthology - Evolution
OrthoDB2004
GeneTree (enSembl)ENSG00000111145
Phylogenetic Trees/Animal Genes : TreeFamELK3
Homologs : HomoloGeneELK3
Homology/Alignments : Family Browser (UCSC)ELK3
Gene fusions - Rearrangements
Fusion: TCGAAES 19p13.3 ELK3 12q23.1 HNSC
Fusion: TCGAC3 19p13.3 ELK3 12q23.1 THCA
Fusion: TCGACOL4A1 13q34 ELK3 12q23.1 HNSC
Fusion: TCGACOL4A2 13q34 ELK3 12q23.1 BLCA
Fusion: TCGACOL6A2 21q22.3 ELK3 12q23.1 HNSC
Fusion: TCGACOL9A3 20q13.33 ELK3 12q23.1 THCA
Fusion: TCGAELK3 12q23.1 AMDHD1 12q23.1 BRCA
Fusion: TCGALGALS3BP 17q25.3 ELK3 12q23.1 LUAD
Fusion: TCGASFN 1p36.11 ELK3 12q23.1 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerELK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK3
dbVarELK3
ClinVarELK3
1000_GenomesELK3 
Exome Variant ServerELK3
ExAC (Exome Aggregation Consortium)ELK3 (select the gene name)
Genetic variants : HAPMAP2004
Genomic Variants (DGV)ELK3 [DGVbeta]
Mutations
ICGC Data PortalELK3 
TCGA Data PortalELK3 
Broad Tumor PortalELK3
OASIS PortalELK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELK3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ELK3
DgiDB (Drug Gene Interaction Database)ELK3
DoCM (Curated mutations)ELK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELK3 (select a term)
intoGenELK3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:96649238-96663613  ENSG00000111145
CONAN: Copy Number AnalysisELK3 
Mutations and Diseases : HGMDELK3
OMIM600247   
MedgenELK3
Genetic Testing Registry ELK3
NextProtP41970 [Medical]
TSGene2004
GENETestsELK3
Huge Navigator ELK3 [HugePedia]
snp3D : Map Gene to Disease2004
BioCentury BCIQELK3
ClinGenELK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2004
Chemical/Pharm GKB GenePA27752
Clinical trialELK3
Miscellaneous
canSAR (ICR)ELK3 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELK3
EVEXELK3
GoPubMedELK3
iHOPELK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:01:30 CEST 2016

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