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ELK3 (ETS transcription factor ELK3)

Identity

Alias (NCBI)ERP
NET
SAP-2
SAP2
HGNC (Hugo) ELK3
HGNC Alias symbERP
NET
SAP2
HGNC Alias nameSRF accessory protein 2
HGNC Previous nameELK3, ETS-domain protein (SRF accessory protein 2)
LocusID (NCBI) 2004
Atlas_Id 40443
Location 12q23.1  [Link to chromosome band 12q23]
Location_base_pair Starts at 96194375 and ends at 96269824 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AES (19p13.3) / ELK3 (12q23.1)C3 (19p13.3) / ELK3 (12q23.1)COL4A1 (13q34) / ELK3 (12q23.1)
COL4A2 (13q34) / ELK3 (12q23.1)COL6A2 (21q22.3) / ELK3 (12q23.1)COL9A3 (20q13.33) / ELK3 (12q23.1)
ELK3 (12q23.1) / AMDHD1 (12q23.1)LGALS3BP (17q25.3) / ELK3 (12q23.1)SFN (1p36.11) / ELK3 (12q23.1)
AES 19p13.3 / ELK3 12q23.1C3 19p13.3 / ELK3 12q23.1COL4A1 13q34 / ELK3 12q23.1
COL4A2 13q34 / ELK3 12q23.1COL6A2 21q22.3 / ELK3 12q23.1COL9A3 20q13.33 / ELK3 12q23.1
ELK3 12q23.1 / AMDHD1 12q23.1LGALS3BP 17q25.3 / ELK3 12q23.1SFN 1p36.11 / ELK3 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ELK3   3325
Cards
Entrez_Gene (NCBI)ELK3    ETS transcription factor ELK3
AliasesERP; NET; SAP-2; SAP2
GeneCards (Weizmann)ELK3
Ensembl hg19 (Hinxton)ENSG00000111145 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111145 [Gene_View]  ENSG00000111145 [Sequence]  chr12:96194375-96269824 [Contig_View]  ELK3 [Vega]
ICGC DataPortalENSG00000111145
TCGA cBioPortalELK3
AceView (NCBI)ELK3
Genatlas (Paris)ELK3
SOURCE (Princeton)ELK3
Genetics Home Reference (NIH)ELK3
Genomic and cartography
GoldenPath hg38 (UCSC)ELK3  -     chr12:96194375-96269824 +  12q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELK3  -     12q23.1   [Description]    (hg19-Feb_2009)
GoldenPathELK3 - 12q23.1 [CytoView hg19]  ELK3 - 12q23.1 [CytoView hg38]
ImmunoBaseENSG00000111145
Genome Data Viewer NCBIELK3 [Mapview hg19]  
OMIM600247   
Gene and transcription
Genbank (Entrez)AK026078 AK312694 AL705041 AW575797 BC017371
RefSeq transcript (Entrez)NM_001303511 NM_005230
Consensus coding sequences : CCDS (NCBI)ELK3
Gene ExpressionELK3 [ NCBI-GEO ]   ELK3 [ EBI - ARRAY_EXPRESS ]   ELK3 [ SEEK ]   ELK3 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK3 [ Firebrowse - Broad ]
GenevisibleExpression of ELK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2004
GTEX Portal (Tissue expression)ELK3
Human Protein AtlasENSG00000111145-ELK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41970
PhosPhoSitePlusP41970
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELK3
SuperfamilyP41970
AlphaFold pdb e-kbP41970   
Human Protein Atlas [tissue]ENSG00000111145-ELK3 [tissue]
HPRD02593
Protein Interaction databases
DIP (DOE-UCLA)P41970
IntAct (EBI)P41970
BioGRIDELK3
STRING (EMBL)ELK3
ZODIACELK3
Ontologies - Pathways
QuickGOP41970
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  regulation of transcription by RNA polymerase II  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  mitochondrion  regulation of transcription by RNA polymerase II  signal transduction  cell differentiation  purine-rich negative regulatory element binding  wound healing  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
NDEx NetworkELK3
Atlas of Cancer Signalling NetworkELK3
Wikipedia pathwaysELK3
Orthology - Evolution
OrthoDB2004
GeneTree (enSembl)ENSG00000111145
Phylogenetic Trees/Animal Genes : TreeFamELK3
Homologs : HomoloGeneELK3
Homology/Alignments : Family Browser (UCSC)ELK3
Gene fusions - Rearrangements
Fusion : MitelmanAES/ELK3 [19p13.3/12q23.1]  
Fusion : MitelmanC3/ELK3 [19p13.3/12q23.1]  
Fusion : MitelmanCOL4A1/ELK3 [13q34/12q23.1]  
Fusion : MitelmanCOL4A2/ELK3 [13q34/12q23.1]  
Fusion : MitelmanCOL6A2/ELK3 [21q22.3/12q23.1]  
Fusion : MitelmanCOL9A3/ELK3 [20q13.33/12q23.1]  
Fusion : MitelmanELK3/AMDHD1 [12q23.1/12q23.1]  
Fusion : MitelmanLGALS3BP/ELK3 [17q25.3/12q23.1]  
Fusion : MitelmanSFN/ELK3 [1p36.11/12q23.1]  
Fusion : QuiverELK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK3
dbVarELK3
ClinVarELK3
MonarchELK3
1000_GenomesELK3 
Exome Variant ServerELK3
GNOMAD BrowserENSG00000111145
Varsome BrowserELK3
ACMGELK3 variants
VarityP41970
Genomic Variants (DGV)ELK3 [DGVbeta]
DECIPHERELK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELK3 
Mutations
ICGC Data PortalELK3 
TCGA Data PortalELK3 
Broad Tumor PortalELK3
OASIS PortalELK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DELK3
Mutations and Diseases : HGMDELK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaELK3
DgiDB (Drug Gene Interaction Database)ELK3
DoCM (Curated mutations)ELK3
CIViC (Clinical Interpretations of Variants in Cancer)ELK3
Cancer3DELK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600247   
Orphanet
DisGeNETELK3
MedgenELK3
Genetic Testing Registry ELK3
NextProtP41970 [Medical]
GENETestsELK3
Target ValidationELK3
Huge Navigator ELK3 [HugePedia]
ClinGenELK3
Clinical trials, drugs, therapy
MyCancerGenomeELK3
Protein Interactions : CTDELK3
Pharm GKB GenePA27752
PharosP41970
Clinical trialELK3
Miscellaneous
canSAR (ICR)ELK3
HarmonizomeELK3
DataMed IndexELK3
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXELK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:01 CEST 2021

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