ELK4 (ETS transcription factor ELK4)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
SAP1
FUSION GENES

Other Information

Locus ID:

NCBI: 2005
MIM: 600246
HGNC: 3326
Ensembl: ENSG00000158711

Variants:

dbSNP: 2005
ClinVar: 2005
TCGA: ENSG00000158711
COSMIC: ELK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158711ENST00000289703P28324
ENSG00000158711ENST00000289703A0A024R997
ENSG00000158711ENST00000357992P28324
ENSG00000158711ENST00000357992A0A024R9C2
ENSG00000158711ENST00000468523A0A087X2F7
ENSG00000158711ENST00000616704P28324
ENSG00000158711ENST00000616704A0A024R9C2

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191369432009Transcriptome sequencing to detect gene fusions in cancer.346
227190192012Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.51
118465622001Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.24
184698652008Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells.14
286557582017Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.14
260280362016Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.13
269388742016Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.9

Citation

Dessen P

ELK4 (ETS transcription factor ELK4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40444/elk4