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ELK4 (ELK4, ETS transcription factor)

Identity

Alias_namesELK4
Alias_symbol (synonym)SAP1
Other alias
HGNC (Hugo) ELK4
LocusID (NCBI) 2005
Atlas_Id 40444
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205607943 and ends at 205632872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELK4 (1q32.1) / DNAJC5 (20q13.33)ELK4 (1q32.1) / SLC26A9 (1q32.1)ELK4 (1q32.1) / SLC45A3 (1q32.1)
ERH (14q24.1) / ELK4 (1q32.1)LIPA (10q23.31) / ELK4 (1q32.1)SLC45A3 (1q32.1) / ELK4 (1q32.1)
SLC45A3 1q32.1 / ELK4 1q32.1ELK4 1q32.1 / SLC26A9 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)ELK4   3326
Cards
Entrez_Gene (NCBI)ELK4  2005  ELK4, ETS transcription factor
AliasesSAP1
GeneCards (Weizmann)ELK4
Ensembl hg19 (Hinxton)ENSG00000158711 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158711 [Gene_View]  chr1:205607943-205632872 [Contig_View]  ELK4 [Vega]
ICGC DataPortalENSG00000158711
TCGA cBioPortalELK4
AceView (NCBI)ELK4
Genatlas (Paris)ELK4
WikiGenes2005
SOURCE (Princeton)ELK4
Genetics Home Reference (NIH)ELK4
Genomic and cartography
GoldenPath hg38 (UCSC)ELK4  -     chr1:205607943-205632872 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELK4  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblELK4 - 1q32.1 [CytoView hg19]  ELK4 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIELK4 [Mapview hg19]  ELK4 [Mapview hg38]
OMIM600246   
Gene and transcription
Genbank (Entrez)AF075044 AI002107 AI005122 AK024944 AL117645
RefSeq transcript (Entrez)NM_001973 NM_021795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ELK4
Cluster EST : UnigeneHs.602654 [ NCBI ]
CGAP (NCI)Hs.602654
Alternative Splicing GalleryENSG00000158711
Gene ExpressionELK4 [ NCBI-GEO ]   ELK4 [ EBI - ARRAY_EXPRESS ]   ELK4 [ SEEK ]   ELK4 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2005
GTEX Portal (Tissue expression)ELK4
Human Protein AtlasENSG00000158711-ELK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28324
Splice isoforms : SwissVarP28324
PhosPhoSitePlusP28324
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELK4
DMDM Disease mutations2005
Blocks (Seattle)ELK4
PDB (SRS)1BC7    1BC8    1HBX    1K6O   
PDB (PDBSum)1BC7    1BC8    1HBX    1K6O   
PDB (IMB)1BC7    1BC8    1HBX    1K6O   
PDB (RSDB)1BC7    1BC8    1HBX    1K6O   
Structural Biology KnowledgeBase1BC7    1BC8    1HBX    1K6O   
SCOP (Structural Classification of Proteins)1BC7    1BC8    1HBX    1K6O   
CATH (Classification of proteins structures)1BC7    1BC8    1HBX    1K6O   
SuperfamilyP28324
Human Protein Atlas [tissue]ENSG00000158711-ELK4 [tissue]
Peptide AtlasP28324
HPRD02592
IPIIPI00002849   IPI00220318   IPI01011423   
Protein Interaction databases
DIP (DOE-UCLA)P28324
IntAct (EBI)P28324
FunCoupENSG00000158711
BioGRIDELK4
STRING (EMBL)ELK4
ZODIACELK4
Ontologies - Pathways
QuickGOP28324
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  protein binding  nucleus  nucleoplasm  cytosol  transcription from RNA polymerase II promoter  cell differentiation  positive regulation of transcription from RNA polymerase II promoter  histone H3 deacetylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  protein binding  nucleus  nucleoplasm  cytosol  transcription from RNA polymerase II promoter  cell differentiation  positive regulation of transcription from RNA polymerase II promoter  histone H3 deacetylation  
Pathways : KEGGMAPK signaling pathway    HTLV-I infection    Transcriptional misregulation in cancer   
NDEx NetworkELK4
Atlas of Cancer Signalling NetworkELK4
Wikipedia pathwaysELK4
Orthology - Evolution
OrthoDB2005
GeneTree (enSembl)ENSG00000158711
Phylogenetic Trees/Animal Genes : TreeFamELK4
HOVERGENP28324
HOGENOMP28324
Homologs : HomoloGeneELK4
Homology/Alignments : Family Browser (UCSC)ELK4
Gene fusions - Rearrangements
Fusion : MitelmanELK4/SLC26A9 [1q32.1/1q32.1]  
Fusion : MitelmanSLC45A3/ELK4 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion: TCGAELK4 1q32.1 SLC26A9 1q32.1 PRAD
Fusion: Tumor Portal ELK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK4
dbVarELK4
ClinVarELK4
1000_GenomesELK4 
Exome Variant ServerELK4
ExAC (Exome Aggregation Consortium)ENSG00000158711
GNOMAD BrowserENSG00000158711
Genetic variants : HAPMAP2005
Genomic Variants (DGV)ELK4 [DGVbeta]
DECIPHERELK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELK4 
Mutations
ICGC Data PortalELK4 
TCGA Data PortalELK4 
Broad Tumor PortalELK4
OASIS PortalELK4 [ Somatic mutations - Copy number]
Cancer Gene: CensusELK4 
Somatic Mutations in Cancer : COSMICELK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDELK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ELK4
DgiDB (Drug Gene Interaction Database)ELK4
DoCM (Curated mutations)ELK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELK4 (select a term)
intoGenELK4
Cancer3DELK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600246   
Orphanet
MedgenELK4
Genetic Testing Registry ELK4
NextProtP28324 [Medical]
TSGene2005
GENETestsELK4
Target ValidationELK4
Huge Navigator ELK4 [HugePedia]
snp3D : Map Gene to Disease2005
BioCentury BCIQELK4
ClinGenELK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2005
Chemical/Pharm GKB GenePA27753
Clinical trialELK4
Miscellaneous
canSAR (ICR)ELK4 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELK4
EVEXELK4
GoPubMedELK4
iHOPELK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:48:39 CET 2017

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