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ELK4 (ETS transcription factor ELK4)

Identity

Alias (NCBI)SAP1
HGNC (Hugo) ELK4
HGNC Alias symbSAP1
HGNC Alias nameSRF accessory protein 1
HGNC Previous nameELK4, ETS-domain protein (SRF accessory protein 1)
LocusID (NCBI) 2005
Atlas_Id 40444
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205619268 and ends at 205632872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELK4 (1q32.1) / DNAJC5 (20q13.33)ELK4 (1q32.1) / SLC26A9 (1q32.1)ELK4 (1q32.1) / SLC45A3 (1q32.1)
ERH (14q24.1) / ELK4 (1q32.1)LIPA (10q23.31) / ELK4 (1q32.1)SLC45A3 (1q32.1) / ELK4 (1q32.1)
SLC45A3 1q32.1 / ELK4 1q32.1ELK4 1q32.1 / SLC26A9 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ELK4   3326
Cards
Entrez_Gene (NCBI)ELK4    ETS transcription factor ELK4
AliasesSAP1
GeneCards (Weizmann)ELK4
Ensembl hg19 (Hinxton)ENSG00000158711 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158711 [Gene_View]  ENSG00000158711 [Sequence]  chr1:205619268-205632872 [Contig_View]  ELK4 [Vega]
ICGC DataPortalENSG00000158711
TCGA cBioPortalELK4
AceView (NCBI)ELK4
Genatlas (Paris)ELK4
SOURCE (Princeton)ELK4
Genetics Home Reference (NIH)ELK4
Genomic and cartography
GoldenPath hg38 (UCSC)ELK4  -     chr1:205619268-205632872 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELK4  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathELK4 - 1q32.1 [CytoView hg19]  ELK4 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000158711
Genome Data Viewer NCBIELK4 [Mapview hg19]  
OMIM600246   
Gene and transcription
Genbank (Entrez)AF075044 AI002107 AI005122 AK024944 AL117645
RefSeq transcript (Entrez)NM_001973 NM_021795
Consensus coding sequences : CCDS (NCBI)ELK4
Gene ExpressionELK4 [ NCBI-GEO ]   ELK4 [ EBI - ARRAY_EXPRESS ]   ELK4 [ SEEK ]   ELK4 [ MEM ]
Gene Expression Viewer (FireBrowse)ELK4 [ Firebrowse - Broad ]
GenevisibleExpression of ELK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2005
GTEX Portal (Tissue expression)ELK4
Human Protein AtlasENSG00000158711-ELK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28324
PhosPhoSitePlusP28324
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ELK4
PDB (RSDB)1BC7    1BC8    1HBX    1K6O   
PDB Europe1BC7    1BC8    1HBX    1K6O   
PDB (PDBSum)1BC7    1BC8    1HBX    1K6O   
PDB (IMB)1BC7    1BC8    1HBX    1K6O   
Structural Biology KnowledgeBase1BC7    1BC8    1HBX    1K6O   
SCOP (Structural Classification of Proteins)1BC7    1BC8    1HBX    1K6O   
CATH (Classification of proteins structures)1BC7    1BC8    1HBX    1K6O   
SuperfamilyP28324
AlphaFold pdb e-kbP28324   
Human Protein Atlas [tissue]ENSG00000158711-ELK4 [tissue]
HPRD02592
Protein Interaction databases
DIP (DOE-UCLA)P28324
IntAct (EBI)P28324
BioGRIDELK4
STRING (EMBL)ELK4
ZODIACELK4
Ontologies - Pathways
QuickGOP28324
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  cell differentiation  positive regulation of transcription by RNA polymerase II  histone H3 deacetylation  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytosol  regulation of transcription by RNA polymerase II  cell differentiation  positive regulation of transcription by RNA polymerase II  histone H3 deacetylation  sequence-specific double-stranded DNA binding  
Pathways : KEGGMAPK signaling pathway    HTLV-I infection    Transcriptional misregulation in cancer   
NDEx NetworkELK4
Atlas of Cancer Signalling NetworkELK4
Wikipedia pathwaysELK4
Orthology - Evolution
OrthoDB2005
GeneTree (enSembl)ENSG00000158711
Phylogenetic Trees/Animal Genes : TreeFamELK4
Homologs : HomoloGeneELK4
Homology/Alignments : Family Browser (UCSC)ELK4
Gene fusions - Rearrangements
Fusion : MitelmanELK4/SLC26A9 [1q32.1/1q32.1]  
Fusion : MitelmanSLC45A3/ELK4 [1q32.1/1q32.1]  
Fusion : QuiverELK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELK4
dbVarELK4
ClinVarELK4
MonarchELK4
1000_GenomesELK4 
Exome Variant ServerELK4
GNOMAD BrowserENSG00000158711
Varsome BrowserELK4
ACMGELK4 variants
VarityP28324
Genomic Variants (DGV)ELK4 [DGVbeta]
DECIPHERELK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELK4 
Mutations
ICGC Data PortalELK4 
TCGA Data PortalELK4 
Broad Tumor PortalELK4
OASIS PortalELK4 [ Somatic mutations - Copy number]
Cancer Gene: CensusELK4 
Somatic Mutations in Cancer : COSMICELK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DELK4
Mutations and Diseases : HGMDELK4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaELK4
DgiDB (Drug Gene Interaction Database)ELK4
DoCM (Curated mutations)ELK4
CIViC (Clinical Interpretations of Variants in Cancer)ELK4
Cancer3DELK4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600246   
Orphanet
DisGeNETELK4
MedgenELK4
Genetic Testing Registry ELK4
NextProtP28324 [Medical]
GENETestsELK4
Target ValidationELK4
Huge Navigator ELK4 [HugePedia]
ClinGenELK4
Clinical trials, drugs, therapy
MyCancerGenomeELK4
Protein Interactions : CTDELK4
Pharm GKB GenePA27753
PharosP28324
Clinical trialELK4
Miscellaneous
canSAR (ICR)ELK4
HarmonizomeELK4
DataMed IndexELK4
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXELK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:01 CEST 2021

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