ELL3 (elongation factor for RNA polymerase II 3)

2013-11-01  

Identity

HGNC
LOCATION
15q15.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 80237
MIM: 609885
HGNC: 23113
Ensembl: ENSG00000128886

Variants:

dbSNP: 80237
ClinVar: 80237
TCGA: ENSG00000128886
COSMIC: ELL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128886ENST00000319359Q9HB65
ENSG00000128886ENST00000433927C9JHD8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
238506912013Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway.10
265403442015Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells.8
288586292017Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.4
285147482017A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells.3
306548432019Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.0

Citation

Dessen P

ELL3 (elongation factor for RNA polymerase II 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53595/ell3