ELOC (elongin C)

2016-12-01 Affiliation

Identity

HGNC

ELOC

LOCATION

8q21.11

LOCUSID

6921

ALIAS

SIII,TCEB1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6921
MIM: 600788
HGNC: 11617
Ensembl: ENSG00000154582

Variants:

dbSNP: 6921
ClinVar: 6921
TCGA: ENSG00000154582
COSMIC: ELOC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000154582	ENST00000284811	Q15369
ENSG00000154582	ENST00000284811	A0A024R7Y5
ENSG00000154582	ENST00000518127	Q15369
ENSG00000154582	ENST00000518127	A0A024R7Y5
ENSG00000154582	ENST00000519082	E5RHG8
ENSG00000154582	ENST00000519487	Q15369
ENSG00000154582	ENST00000519487	A0A024R7Y5
ENSG00000154582	ENST00000520210	Q15369
ENSG00000154582	ENST00000520242	Q15369
ENSG00000154582	ENST00000520242	A0A024R7Y5
ENSG00000154582	ENST00000522337	Q15369
ENSG00000154582	ENST00000522337	A0A024R7Y5
ENSG00000154582	ENST00000523815	Q15369
ENSG00000154582	ENST00000523815	A0A024R7Y5
ENSG00000154582	ENST00000602840	R4GMY8
ENSG00000154582	ENST00000622804	Q15369
ENSG00000154582	ENST00000622804	A0A024R7Y5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Renal cell carcinoma	KEGG	ko05211
Ubiquitin mediated proteolysis	KEGG	hsa04120
Pathways in cancer	KEGG	hsa05200
Renal cell carcinoma	KEGG	hsa05211
ECV complex	KEGG	hsa_M00383
ECS complex	KEGG	hsa_M00388
ECS complex	KEGG	M00388
HIF-1 signaling pathway	KEGG	hsa04066
ECV complex	KEGG	M00383
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Elongation	REACTOME	R-HSA-167169
Tat-mediated elongation of the HIV-1 transcript	REACTOME	R-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 Tat	REACTOME	R-HSA-167200
HIV elongation arrest and recovery	REACTOME	R-HSA-167287
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Pausing and recovery of HIV elongation	REACTOME	R-HSA-167290
Tat-mediated HIV elongation arrest and recovery	REACTOME	R-HSA-167243
Pausing and recovery of Tat-mediated HIV elongation	REACTOME	R-HSA-167238
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Vif-mediated degradation of APOBEC3G	REACTOME	R-HSA-180585
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
TP53 Regulates Transcription of DNA Repair Genes	REACTOME	R-HSA-6796648

References

Pubmed ID	Year	Title	Citations
14564014	2003	Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.	579
15781449	2005	Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function.	94
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16675548	2006	Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.	53
24367103	2014	AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.	37
15590664	2005	ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.	36
25661653	2015	Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.	21
23988114	2013	Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.	17
25676555	2015	TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype.	15
23083832	2012	A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression.	14

Citation

Dessen P

ELOC (elongin C)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56669/eloc