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ELOVL1 (ELOVL fatty acid elongase 1)

Identity

Alias_nameselongation of very long chain fatty acids (FEN1/Elo2
Alias_symbol (synonym)Ssc1
Other aliasCGI-88
HGNC (Hugo) ELOVL1
LocusID (NCBI) 64834
Atlas_Id 54281
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43363397 and ends at 43367738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELOVL1 (1p34.2) / ELOVL1 (1p34.2)ELOVL1 (1p34.2) / NFASC (1q32.1)LOC100507412 (-) / ELOVL1 (1p34.2)
MED8 (1p34.2) / ELOVL1 (1p34.2)SMYD3 (1q44) / ELOVL1 (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ELOVL1   14418
Cards
Entrez_Gene (NCBI)ELOVL1  64834  ELOVL fatty acid elongase 1
AliasesCGI-88; Ssc1
GeneCards (Weizmann)ELOVL1
Ensembl hg19 (Hinxton)ENSG00000066322 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066322 [Gene_View]  chr1:43363397-43367738 [Contig_View]  ELOVL1 [Vega]
ICGC DataPortalENSG00000066322
TCGA cBioPortalELOVL1
AceView (NCBI)ELOVL1
Genatlas (Paris)ELOVL1
WikiGenes64834
SOURCE (Princeton)ELOVL1
Genetics Home Reference (NIH)ELOVL1
Genomic and cartography
GoldenPath hg38 (UCSC)ELOVL1  -     chr1:43363397-43367738 -  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ELOVL1  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblELOVL1 - 1p34.2 [CytoView hg19]  ELOVL1 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIELOVL1 [Mapview hg19]  ELOVL1 [Mapview hg38]
OMIM611813   
Gene and transcription
Genbank (Entrez)AA635780 AF151846 AF336793 AK001653 AK130174
RefSeq transcript (Entrez)NM_001256399 NM_001256401 NM_001256402 NM_022821
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ELOVL1
Cluster EST : UnigeneHs.25597 [ NCBI ]
CGAP (NCI)Hs.25597
Alternative Splicing GalleryENSG00000066322
Gene ExpressionELOVL1 [ NCBI-GEO ]   ELOVL1 [ EBI - ARRAY_EXPRESS ]   ELOVL1 [ SEEK ]   ELOVL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ELOVL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64834
GTEX Portal (Tissue expression)ELOVL1
Human Protein AtlasENSG00000066322-ELOVL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BW60   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BW60  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BW60
Splice isoforms : SwissVarQ9BW60
PhosPhoSitePlusQ9BW60
Domaine pattern : Prosite (Expaxy)ELO (PS01188)   
Domains : Interpro (EBI)ELO_CS    ELO_fam    ELOVL1   
Domain families : Pfam (Sanger)ELO (PF01151)   
Domain families : Pfam (NCBI)pfam01151   
Conserved Domain (NCBI)ELOVL1
DMDM Disease mutations64834
Blocks (Seattle)ELOVL1
SuperfamilyQ9BW60
Human Protein Atlas [tissue]ENSG00000066322-ELOVL1 [tissue]
Peptide AtlasQ9BW60
HPRD10935
IPIIPI00010187   IPI00910626   
Protein Interaction databases
DIP (DOE-UCLA)Q9BW60
IntAct (EBI)Q9BW60
FunCoupENSG00000066322
BioGRIDELOVL1
STRING (EMBL)ELOVL1
ZODIACELOVL1
Ontologies - Pathways
QuickGOQ9BW60
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid elongase activity  fatty acid elongase activity  membrane  fatty acid elongation, saturated fatty acid  sphingolipid biosynthetic process  integral component of endoplasmic reticulum membrane  fatty acid elongation, monounsaturated fatty acid  long-chain fatty-acyl-CoA biosynthetic process  alpha-linolenic acid metabolic process  very long-chain fatty acid biosynthetic process  linoleic acid metabolic process  3-oxo-arachidoyl-CoA synthase activity  3-oxo-cerotoyl-CoA synthase activity  3-oxo-lignoceronyl-CoA synthase activity  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid elongase activity  fatty acid elongase activity  membrane  fatty acid elongation, saturated fatty acid  sphingolipid biosynthetic process  integral component of endoplasmic reticulum membrane  fatty acid elongation, monounsaturated fatty acid  long-chain fatty-acyl-CoA biosynthetic process  alpha-linolenic acid metabolic process  very long-chain fatty acid biosynthetic process  linoleic acid metabolic process  3-oxo-arachidoyl-CoA synthase activity  3-oxo-cerotoyl-CoA synthase activity  3-oxo-lignoceronyl-CoA synthase activity  
Pathways : KEGGFatty acid elongation   
NDEx NetworkELOVL1
Atlas of Cancer Signalling NetworkELOVL1
Wikipedia pathwaysELOVL1
Orthology - Evolution
OrthoDB64834
GeneTree (enSembl)ENSG00000066322
Phylogenetic Trees/Animal Genes : TreeFamELOVL1
HOVERGENQ9BW60
HOGENOMQ9BW60
Homologs : HomoloGeneELOVL1
Homology/Alignments : Family Browser (UCSC)ELOVL1
Gene fusions - Rearrangements
Fusion : MitelmanSMYD3/ELOVL1 [1q44/1p34.2]  [t(1;1)(p34;q44)]  
Fusion: Tumor Portal ELOVL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerELOVL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ELOVL1
dbVarELOVL1
ClinVarELOVL1
1000_GenomesELOVL1 
Exome Variant ServerELOVL1
ExAC (Exome Aggregation Consortium)ENSG00000066322
GNOMAD BrowserENSG00000066322
Genetic variants : HAPMAP64834
Genomic Variants (DGV)ELOVL1 [DGVbeta]
DECIPHERELOVL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisELOVL1 
Mutations
ICGC Data PortalELOVL1 
TCGA Data PortalELOVL1 
Broad Tumor PortalELOVL1
OASIS PortalELOVL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICELOVL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDELOVL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ELOVL1
DgiDB (Drug Gene Interaction Database)ELOVL1
DoCM (Curated mutations)ELOVL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ELOVL1 (select a term)
intoGenELOVL1
Cancer3DELOVL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611813   
Orphanet
MedgenELOVL1
Genetic Testing Registry ELOVL1
NextProtQ9BW60 [Medical]
TSGene64834
GENETestsELOVL1
Target ValidationELOVL1
Huge Navigator ELOVL1 [HugePedia]
snp3D : Map Gene to Disease64834
BioCentury BCIQELOVL1
ClinGenELOVL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64834
Chemical/Pharm GKB GenePA27760
Clinical trialELOVL1
Miscellaneous
canSAR (ICR)ELOVL1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineELOVL1
EVEXELOVL1
GoPubMedELOVL1
iHOPELOVL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:48:42 CET 2017

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