ELP3 (elongator acetyltransferase complex subunit 3)

2014-08-01  

Identity

HGNC
LOCATION
8p21.1
LOCUSID
ALIAS
KAT9
FUSION GENES

Other Information

Locus ID:

NCBI: 55140
MIM: 612722
HGNC: 20696
Ensembl: ENSG00000134014

Variants:

dbSNP: 55140
ClinVar: 55140
TCGA: ENSG00000134014
COSMIC: ELP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134014ENST00000256398Q9H9T3
ENSG00000134014ENST00000380353Q9H9T3
ENSG00000134014ENST00000517975H0YC54
ENSG00000134014ENST00000518112E5RG26
ENSG00000134014ENST00000519261E5RIU1
ENSG00000134014ENST00000520270E5RIC0
ENSG00000134014ENST00000520288E5RIZ7
ENSG00000134014ENST00000521015Q9H9T3
ENSG00000134014ENST00000521099E5RHY2
ENSG00000134014ENST00000521570E5RHR2
ENSG00000134014ENST00000523357H0YAP7
ENSG00000134014ENST00000523687E5RG26
ENSG00000134014ENST00000524103B4DKA4
ENSG00000134014ENST00000537665Q9H9T3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189969182009Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.84
189969182009Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.84
247693942014Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.61
278110572016Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.33
200361972010Elongator - an emerging role in neurological disorders.26
208773002012Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.26
206265652010The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila.16
251488702014Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.12
175584512007hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells.5
194291072009ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.4

Citation

Dessen P

ELP3 (elongator acetyltransferase complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54282/elp3