ELP5 (elongator acetyltransferase complex subunit 5)

2012-12-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
C17orf81,DERP6,HSPC002,MST071,MSTP071

Other Information

Locus ID:

NCBI: 23587
MIM: 615019
HGNC: 30617
Ensembl: ENSG00000170291

Variants:

dbSNP: 23587
ClinVar: 23587
TCGA: ENSG00000170291
COSMIC: ELP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170291ENST00000354429Q8TE02
ENSG00000170291ENST00000356683Q8TE02
ENSG00000170291ENST00000396627Q8TE02
ENSG00000170291ENST00000396628Q8TE02
ENSG00000170291ENST00000570322I3L437
ENSG00000170291ENST00000570500I3L1A8
ENSG00000170291ENST00000571146I3L2A9
ENSG00000170291ENST00000572104I3L200
ENSG00000170291ENST00000573513I3L3N8
ENSG00000170291ENST00000573657Q8TE02
ENSG00000170291ENST00000573699I3L2T0
ENSG00000170291ENST00000574255Q8TE02
ENSG00000170291ENST00000574841I3NI50
ENSG00000170291ENST00000574993Q8TE02
ENSG00000170291ENST00000576496I3L1Q3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
228549662012DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.17
168501832006Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53.4
317922102019Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.2

Citation

Dessen P

ELP5 (elongator acetyltransferase complex subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53111/elp5