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EMC4 (ER membrane protein complex subunit 4)

Identity

Alias (NCBI)PIG17
TMEM85
HGNC (Hugo) EMC4
HGNC Alias symbFLJ90746
MGC24415
PIG17
HGNC Previous nameTMEM85
HGNC Previous nametransmembrane protein 85
LocusID (NCBI) 51234
Atlas_Id 62813
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 34225016 and ends at 34230151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EMC4   28032
Cards
Entrez_Gene (NCBI)EMC4    ER membrane protein complex subunit 4
AliasesPIG17; TMEM85
GeneCards (Weizmann)EMC4
Ensembl hg19 (Hinxton)ENSG00000128463 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128463 [Gene_View]  ENSG00000128463 [Sequence]  chr15:34225016-34230151 [Contig_View]  EMC4 [Vega]
ICGC DataPortalENSG00000128463
TCGA cBioPortalEMC4
AceView (NCBI)EMC4
Genatlas (Paris)EMC4
SOURCE (Princeton)EMC4
Genetics Home Reference (NIH)EMC4
Genomic and cartography
GoldenPath hg38 (UCSC)EMC4  -     chr15:34225016-34230151 +  15q14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EMC4  -     15q14   [Description]    (hg19-Feb_2009)
GoldenPathEMC4 - 15q14 [CytoView hg19]  EMC4 - 15q14 [CytoView hg38]
ImmunoBaseENSG00000128463
Genome Data Viewer NCBIEMC4 [Mapview hg19]  
OMIM616245   
Gene and transcription
Genbank (Entrez)AF151018 AK075227 AK290524 AK296184 AY336092
RefSeq transcript (Entrez)NM_001286420 NM_001351373 NM_016454
Consensus coding sequences : CCDS (NCBI)EMC4
Gene ExpressionEMC4 [ NCBI-GEO ]   EMC4 [ EBI - ARRAY_EXPRESS ]   EMC4 [ SEEK ]   EMC4 [ MEM ]
Gene Expression Viewer (FireBrowse)EMC4 [ Firebrowse - Broad ]
GenevisibleExpression of EMC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51234
GTEX Portal (Tissue expression)EMC4
Human Protein AtlasENSG00000128463-EMC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5J8M3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5J8M3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5J8M3
PhosPhoSitePlusQ5J8M3
Domains : Interpro (EBI)TMEM85/Emc4   
Domain families : Pfam (Sanger)DUF1077 (PF06417)   
Domain families : Pfam (NCBI)pfam06417   
Conserved Domain (NCBI)EMC4
PDB (RSDB)6Z3W   
PDB Europe6Z3W   
PDB (PDBSum)6Z3W   
PDB (IMB)6Z3W   
Structural Biology KnowledgeBase6Z3W   
SCOP (Structural Classification of Proteins)6Z3W   
CATH (Classification of proteins structures)6Z3W   
SuperfamilyQ5J8M3
AlphaFold pdb e-kbQ5J8M3   
Human Protein Atlas [tissue]ENSG00000128463-EMC4 [tissue]
HPRD14233
Protein Interaction databases
DIP (DOE-UCLA)Q5J8M3
IntAct (EBI)Q5J8M3
BioGRIDEMC4
STRING (EMBL)EMC4
ZODIACEMC4
Ontologies - Pathways
QuickGOQ5J8M3
Ontology : AmiGOprotein binding  apoptotic process  integral component of membrane  integral component of endoplasmic reticulum membrane  membrane insertase activity  protein insertion into ER membrane by stop-transfer membrane-anchor sequence  tail-anchored membrane protein insertion into ER membrane  EMC complex  EMC complex  
Ontology : EGO-EBIprotein binding  apoptotic process  integral component of membrane  integral component of endoplasmic reticulum membrane  membrane insertase activity  protein insertion into ER membrane by stop-transfer membrane-anchor sequence  tail-anchored membrane protein insertion into ER membrane  EMC complex  EMC complex  
NDEx NetworkEMC4
Atlas of Cancer Signalling NetworkEMC4
Wikipedia pathwaysEMC4
Orthology - Evolution
OrthoDB51234
GeneTree (enSembl)ENSG00000128463
Phylogenetic Trees/Animal Genes : TreeFamEMC4
Homologs : HomoloGeneEMC4
Homology/Alignments : Family Browser (UCSC)EMC4
Gene fusions - Rearrangements
Fusion : QuiverEMC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEMC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EMC4
dbVarEMC4
ClinVarEMC4
MonarchEMC4
1000_GenomesEMC4 
Exome Variant ServerEMC4
GNOMAD BrowserENSG00000128463
Varsome BrowserEMC4
ACMGEMC4 variants
VarityQ5J8M3
Genomic Variants (DGV)EMC4 [DGVbeta]
DECIPHEREMC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEMC4 
Mutations
ICGC Data PortalEMC4 
TCGA Data PortalEMC4 
Broad Tumor PortalEMC4
OASIS PortalEMC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEMC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEMC4
Mutations and Diseases : HGMDEMC4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEMC4
DgiDB (Drug Gene Interaction Database)EMC4
DoCM (Curated mutations)EMC4
CIViC (Clinical Interpretations of Variants in Cancer)EMC4
Cancer3DEMC4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616245   
Orphanet
DisGeNETEMC4
MedgenEMC4
Genetic Testing Registry EMC4
NextProtQ5J8M3 [Medical]
GENETestsEMC4
Target ValidationEMC4
Huge Navigator EMC4 [HugePedia]
ClinGenEMC4
Clinical trials, drugs, therapy
MyCancerGenomeEMC4
Protein Interactions : CTDEMC4
Pharm GKB GenePA143485634
PharosQ5J8M3
Clinical trialEMC4
Miscellaneous
canSAR (ICR)EMC4
HarmonizomeEMC4
DataMed IndexEMC4
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEMC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:48:53 CEST 2021

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