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EMX2 (empty spiracles homeobox 2)

Identity

Alias (NCBI)-
HGNC (Hugo) EMX2
HGNC Previous nameempty spiracles homolog 2 (Drosophila)
LocusID (NCBI) 2018
Atlas_Id 40449
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 117542746 and ends at 117549546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)EMX2   3341
Cards
Entrez_Gene (NCBI)EMX2    empty spiracles homeobox 2
Aliases
GeneCards (Weizmann)EMX2
Ensembl hg19 (Hinxton)ENSG00000170370 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170370 [Gene_View]  ENSG00000170370 [Sequence]  chr10:117542746-117549546 [Contig_View]  EMX2 [Vega]
ICGC DataPortalENSG00000170370
TCGA cBioPortalEMX2
AceView (NCBI)EMX2
Genatlas (Paris)EMX2
SOURCE (Princeton)EMX2
Genetics Home Reference (NIH)EMX2
Genomic and cartography
GoldenPath hg38 (UCSC)EMX2  -     chr10:117542746-117549546 +  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EMX2  -     10q26.11   [Description]    (hg19-Feb_2009)
GoldenPathEMX2 - 10q26.11 [CytoView hg19]  EMX2 - 10q26.11 [CytoView hg38]
ImmunoBaseENSG00000170370
Genome Data Viewer NCBIEMX2 [Mapview hg19]  
OMIM269160   600035   
Gene and transcription
Genbank (Entrez)AF301598 AI701984 AK055041 AK311352 AL161811
RefSeq transcript (Entrez)NM_001165924 NM_004098
Consensus coding sequences : CCDS (NCBI)EMX2
Gene ExpressionEMX2 [ NCBI-GEO ]   EMX2 [ EBI - ARRAY_EXPRESS ]   EMX2 [ SEEK ]   EMX2 [ MEM ]
Gene Expression Viewer (FireBrowse)EMX2 [ Firebrowse - Broad ]
GenevisibleExpression of EMX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2018
GTEX Portal (Tissue expression)EMX2
Human Protein AtlasENSG00000170370-EMX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04743   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04743  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04743
PhosPhoSitePlusQ04743
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_metazoa    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)EMX2
SuperfamilyQ04743
AlphaFold pdb e-kbQ04743   
Human Protein Atlas [tissue]ENSG00000170370-EMX2 [tissue]
HPRD02495
Protein Interaction databases
DIP (DOE-UCLA)Q04743
IntAct (EBI)Q04743
BioGRIDEMX2
STRING (EMBL)EMX2
ZODIACEMX2
Ontologies - Pathways
QuickGOQ04743
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  central nervous system development  brain development  anterior/posterior pattern specification  dentate gyrus development  cerebral cortex regionalization  cell proliferation in forebrain  forebrain cell migration  neuron differentiation  response to drug  ureter morphogenesis  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  central nervous system development  brain development  anterior/posterior pattern specification  dentate gyrus development  cerebral cortex regionalization  cell proliferation in forebrain  forebrain cell migration  neuron differentiation  response to drug  ureter morphogenesis  sequence-specific double-stranded DNA binding  
NDEx NetworkEMX2
Atlas of Cancer Signalling NetworkEMX2
Wikipedia pathwaysEMX2
Orthology - Evolution
OrthoDB2018
GeneTree (enSembl)ENSG00000170370
Phylogenetic Trees/Animal Genes : TreeFamEMX2
Homologs : HomoloGeneEMX2
Homology/Alignments : Family Browser (UCSC)EMX2
Gene fusions - Rearrangements
Fusion : QuiverEMX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEMX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EMX2
dbVarEMX2
ClinVarEMX2
MonarchEMX2
1000_GenomesEMX2 
Exome Variant ServerEMX2
GNOMAD BrowserENSG00000170370
Varsome BrowserEMX2
ACMGEMX2 variants
VarityQ04743
Genomic Variants (DGV)EMX2 [DGVbeta]
DECIPHEREMX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEMX2 
Mutations
ICGC Data PortalEMX2 
TCGA Data PortalEMX2 
Broad Tumor PortalEMX2
OASIS PortalEMX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEMX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEMX2
Mutations and Diseases : HGMDEMX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEMX2
DgiDB (Drug Gene Interaction Database)EMX2
DoCM (Curated mutations)EMX2
CIViC (Clinical Interpretations of Variants in Cancer)EMX2
Cancer3DEMX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM269160    600035   
Orphanet580   
DisGeNETEMX2
MedgenEMX2
Genetic Testing Registry EMX2
NextProtQ04743 [Medical]
GENETestsEMX2
Target ValidationEMX2
Huge Navigator EMX2 [HugePedia]
ClinGenEMX2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeEMX2
Protein Interactions : CTDEMX2
Pharm GKB GenePA27778
PharosQ04743
Clinical trialEMX2
Miscellaneous
canSAR (ICR)EMX2
HarmonizomeEMX2
DataMed IndexEMX2
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEMX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:09 CEST 2021
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