ENDOG (endonuclease G)

2007-02-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 2021
MIM: 600440
HGNC: 3346
Ensembl: ENSG00000167136

Variants:

dbSNP: 2021
ClinVar: 2021
TCGA: ENSG00000167136
COSMIC: ENDOG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167136ENST00000372642Q14249
ENSG00000167136ENST00000372642E5KNL5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243711202014Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans.58
241295132013Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.30
161338722005Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP.28
151828542004Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor.27
124449642002Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane space.22
197818502010EGCG induces apoptosis in human laryngeal epidermoid carcinoma Hep2 cells via mitochondria with the release of apoptosis-inducing factor and endonuclease G.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
237648472013CHIP has a protective role against oxidative stress-induced cell death through specific regulation of endonuclease G.16
191990362009Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.12
170467512006Endonuclease G promotes cell death of non-invasive human breast cancer cells.11

Citation

Dessen P

ENDOG (endonuclease G)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43940/endog