ENGASE (endo-beta-N-acetylglucosaminidase)

2014-11-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 64772
MIM: 611898
HGNC: 24622
Ensembl: ENSG00000167280

Variants:

dbSNP: 64772
ClinVar: 64772
TCGA: ENSG00000167280
COSMIC: ENGASE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167280ENST00000300682J9JID0
ENSG00000167280ENST00000311595F8W925
ENSG00000167280ENST00000578419J3QLG5
ENSG00000167280ENST00000579016Q8NFI3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Other glycan degradationKEGGhsa00511
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185866802008Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis.46
121145442002Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol.30
204135122010Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes.28
200260472010Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.11
206685202010Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells.10
129054692003Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion.8
218735612011Telomere dysfunction-related serological markers are associated with type 2 diabetes.6
269234192016Relationship of urinary endothelin-1 with estimated glomerular filtration rate in autosomal dominant polycystic kidney disease: a pilot cross-sectional analysis.1

Citation

Dessen P

ENGASE (endo-beta-N-acetylglucosaminidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62830/engase