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ENO2 (enolase 2)

Identity

Alias_namesenolase 2 (gamma
Other aliasHEL-S-279
NSE
HGNC (Hugo) ENO2
LocusID (NCBI) 2026
Atlas_Id 46227
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6914450 and ends at 6923696 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLASRP (19q13.32) / ENO2 (12p13.31)ENO2 (12p13.31) / ACRBP (12p13.31)ENO2 (12p13.31) / TNRC18 (7p22.1)
LOC100507412 (-) / ENO2 (12p13.31)NAE1 (16q22.1) / ENO2 (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ENO2   3353
Cards
Entrez_Gene (NCBI)ENO2  2026  enolase 2
AliasesHEL-S-279; NSE
GeneCards (Weizmann)ENO2
Ensembl hg19 (Hinxton)ENSG00000111674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111674 [Gene_View]  chr12:6914450-6923696 [Contig_View]  ENO2 [Vega]
IGGc DataPortalENSG00000111674
TCGA cBioPortalENO2
AceView (NCBI)ENO2
Genatlas (Paris)ENO2
WikiGenes2026
SOURCE (Princeton)ENO2
Genetics Home Reference (NIH)ENO2
Genomic and cartography
GoldenPath hg38 (UCSC)ENO2  -     chr12:6914450-6923696 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ENO2  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblENO2 - 12p13.31 [CytoView hg19]  ENO2 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIENO2 [Mapview hg19]  ENO2 [Mapview hg38]
OMIM131360   
Gene and transcription
Genbank (Entrez)AK124656 AK290525 AK295220 AK312402 BC002745
RefSeq transcript (Entrez)NM_001975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ENO2
Cluster EST : UnigeneHs.511915 [ NCBI ]
CGAP (NCI)Hs.511915
Alternative Splicing GalleryENSG00000111674
Gene ExpressionENO2 [ NCBI-GEO ]   ENO2 [ EBI - ARRAY_EXPRESS ]   ENO2 [ SEEK ]   ENO2 [ MEM ]
Gene Expression Viewer (FireBrowse)ENO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2026
GTEX Portal (Tissue expression)ENO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09104   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09104  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09104
Splice isoforms : SwissVarP09104
Catalytic activity : Enzyme4.2.1.11 [ Enzyme-Expasy ]   4.2.1.114.2.1.11 [ IntEnz-EBI ]   4.2.1.11 [ BRENDA ]   4.2.1.11 [ KEGG ]   
PhosPhoSitePlusP09104
Domaine pattern : Prosite (Expaxy)ENOLASE (PS00164)   
Domains : Interpro (EBI)Enolase    Enolase_C    Enolase_C-like    Enolase_CS    Enolase_N    Enolase_N-like   
Domain families : Pfam (Sanger)Enolase_C (PF00113)    Enolase_N (PF03952)¦nbsp{&n`sp; 
Domain families : Pfam (NCBI)pfam00113    pfam03952   
Domain families : Smart (EMBL)Enolase_C (SM01192)  Enolase_N (SM01193)  
Conserved Domain (NCBI)ENO2
DMDM Disease mutations2026
Blocks (Seattle)ENO2
PDB (SRS)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
PDB (PDBSum)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
PDB (IMB)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
PDB (RSDB)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
Structural Biology KnowledgeBase1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
SCOP (Structural Classification of Proteins)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
CATH (Classification of proteins structures)1TE6    2AKM    2AKZ    3UCC    3UCD    3UJE    3UJF    3UJR    3UJS    4ZA0    4ZCW    5EU9   
SuperfamilyP09104
Human Protein AtlasENSG00000111674
Peptide AtlasP09104
HPRD00573
IPIIPI00216171   IPI01013948   IPI01014290   IPI00791564   IPI01011858   IPI01011037   IPI01011411   
Protein Interaction databases
DIP (DOE-UCLA)P09104
IntAct (EBI)P09104
FunCoupENSG00000111674
BioGRIDENO2
STRING (EMBL)ENO2
ZODIACENO2
Ontologies - Pathways
QuickGOP09104
Ontology : AmiGOphosphopyruvate hydratase complex  magnesium ion binding  photoreceptor inner segment  phosphopyruvate hydratase activity  phosphopyruvate hydratase activity  protein binding  extracellular space  cytosol  plasma membrane  gluconeogenesis  glycolytic process  membrane  perikaryon  myelin sheath  canonical glycolysis  extracellular exosome  
Ontology : EGO-EBIphosphopyruvate hydratase complex  magnesium ion binding  photoreceptor inner segment  phosphopyruvate hydratase activity  phosphopyruvate hydratase activity  protein binding  extracellular space  cytosol  plasma membrane  gluconeogenesis  glycolytic process  membrane  perikaryon  myelin sheath  canonical glycolysis  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    RNA degradation    HIF-1 signaling pathway   
NDEx NetworkENO2
Atlas of Cancer Signalling NetworkENO2
Wikipedia pathwaysENO2
Orthology - Evolution
OrthoDB2026
GeneTree (enSembl)ENSG00000111674
Phylogenetic Trees/Animal Genes : TreeFamENO2
HOVERGENP09104
HOGENOMP09104
Homologs : HomoloGeneENO2
Homology/Alignments : Family Browser (UCSC)ENO2
Gene fusions - Rearrangements
Fusion : MitelmanENO2/ACRBP [12p13.31/12p13.31]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENO2
dbVarENO2
ClinVarENO2
1000_GenomesENO2 
Exome Variant ServerENO2
ExAC (Exome Aggregation Consortium)ENO2 (select the gene name)
Genetic variants : HAPMAP2026
Genomic Variants (DGV)ENO2 [DGVbeta]
DECIPHERENO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisENO2 
Mutations
ICGC Data PortalENO2 
TCGA Data PortalENO2 
Broad Tumor PortalENO2
OASIS PortalENO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENO2
DgiDB (Drug Gene Interaction Database)ENO2
DoCM (Curated mutations)ENO2 (select the gene name)
CIViC (Clinic`l Iītevpretations of Variants in Cancer)ENO2 (select a term)
intoGenENO2
Cancer3DENO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131360   
Orphanet
MedgenENO2
Genetic Testing Registry ENO2
NextProtP09104 [Medical]
TSGene2026
GENETestsENO2
Target ValidationENO2
Huge Navigator ENO2 [HugePedia]
snp3D : Map Gene to Disease2026
BioCentury BCIQENO2
ClinGenENO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2026
Chemical/Pharm GKB GenePA27788
Clinical trialENO2
Miscellaneous
canSAR (ICR)ENO2 (select the gene name)
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENO2
EVEXENO2
GoPubMedENO2
iHOPENO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:52:36 CEST 2017

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