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ENPEP (glutamyl aminopeptidase)

Identity

Alias_namesglutamyl aminopeptidase (aminopeptidase A)
Alias_symbol (synonym)gp160
CD249
HGNC (Hugo) ENPEP
LocusID (NCBI) 2028
Atlas_Id 40454
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 111397229 and ends at 111484493 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ELOVL6 (4q25) / ENPEP (4q25)ENPEP (4q25) / CEP250 (20q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ENPEP   3355
Cards
Entrez_Gene (NCBI)ENPEP  2028  glutamyl aminopeptidase
AliasesAPA; CD249; gp160
GeneCards (Weizmann)ENPEP
Ensembl hg19 (Hinxton)ENSG00000138792 [Gene_View]  chr4:111397229-111484493 [Contig_View]  ENPEP [Vega]
Ensembl hg38 (Hinxton)ENSG00000138792 [Gene_View]  chr4:111397229-111484493 [Contig_View]  ENPEP [Vega]
ICGC DataPortalENSG00000138792
TCGA cBioPortalENPEP
AceView (NCBI)ENPEP
Genatlas (Paris)ENPEP
WikiGenes2028
SOURCE (Princeton)ENPEP
Genetics Home Reference (NIH)ENPEP
Genomic and cartography
GoldenPath hg19 (UCSC)ENPEP  -     chr4:111397229-111484493 +  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ENPEP  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblENPEP - 4q25 [CytoView hg19]  ENPEP - 4q25 [CytoView hg38]
Mapping of homologs : NCBIENPEP [Mapview hg19]  ENPEP [Mapview hg38]
OMIM138297   
Gene and transcription
Genbank (Entrez)AI640493 AK313412 AL568777 AM888273 AM888274
RefSeq transcript (Entrez)NM_001977
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ENPEP
Cluster EST : UnigeneHs.435765 [ NCBI ]
CGAP (NCI)Hs.435765
Alternative Splicing GalleryENSG00000138792
Gene ExpressionENPEP [ NCBI-GEO ]   ENPEP [ EBI - ARRAY_EXPRESS ]   ENPEP [ SEEK ]   ENPEP [ MEM ]
Gene Expression Viewer (FireBrowse)ENPEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2028
GTEX Portal (Tissue expression)ENPEP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07075
Splice isoforms : SwissVarQ07075
Catalytic activity : Enzyme3.4.11.7 [ Enzyme-Expasy ]   3.4.11.73.4.11.7 [ IntEnz-EBI ]   3.4.11.7 [ BRENDA ]   3.4.11.7 [ KEGG ]   
PhosPhoSitePlusQ07075
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    Peptidase_M1    Peptidase_M1_N   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)ENPEP
DMDM Disease mutations2028
Blocks (Seattle)ENPEP
PDB (SRS)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (PDBSum)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (IMB)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (RSDB)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
Structural Biology KnowledgeBase4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
SCOP (Structural Classification of Proteins)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
CATH (Classification of proteins structures)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
SuperfamilyQ07075
Human Protein AtlasENSG00000138792
Peptide AtlasQ07075
HPRD08848
IPIIPI00014375   IPI00967998   
Protein Interaction databases
DIP (DOE-UCLA)Q07075
IntAct (EBI)Q07075
FunCoupENSG00000138792
BioGRIDENPEP
STRING (EMBL)ENPEP
ZODIACENPEP
Ontologies - Pathways
QuickGOQ07075
Ontology : AmiGOangiogenesis  angiotensin maturation  angiotensin catabolic process in blood  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  aminopeptidase activity  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  brush border  cell-cell signaling  metallopeptidase activity  zinc ion binding  cell proliferation  cell proliferation  external side of plasma membrane  apical plasma membrane  cell migration  cytoplasmic vesicle  glomerulus development  peptide binding  peptide catabolic process  apical part of cell  metalloaminopeptidase activity  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIangiogenesis  angiotensin maturation  angiotensin catabolic process in blood  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  aminopeptidase activity  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  brush border  cell-cell signaling  metallopeptidase activity  zinc ion binding  cell proliferation  cell proliferation  external side of plasma membrane  apical plasma membrane  cell migration  cytoplasmic vesicle  glomerulus development  peptide binding  peptide catabolic process  apical part of cell  metalloaminopeptidase activity  metalloaminopeptidase activity  extracellular exosome  
Pathways : KEGGRenin-angiotensin system   
NDEx NetworkENPEP
Atlas of Cancer Signalling NetworkENPEP
Wikipedia pathwaysENPEP
Orthology - Evolution
OrthoDB2028
GeneTree (enSembl)ENSG00000138792
Phylogenetic Trees/Animal Genes : TreeFamENPEP
HOVERGENQ07075
HOGENOMQ07075
Homologs : HomoloGeneENPEP
Homology/Alignments : Family Browser (UCSC)ENPEP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENPEP
dbVarENPEP
ClinVarENPEP
1000_GenomesENPEP 
Exome Variant ServerENPEP
ExAC (Exome Aggregation Consortium)ENPEP (select the gene name)
Genetic variants : HAPMAP2028
Genomic Variants (DGV)ENPEP [DGVbeta]
DECIPHER (Syndromes)4:111397229-111484493  ENSG00000138792
CONAN: Copy Number AnalysisENPEP 
Mutations
ICGC Data PortalENPEP 
TCGA Data PortalENPEP 
Broad Tumor PortalENPEP
OASIS PortalENPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENPEP
DgiDB (Drug Gene Interaction Database)ENPEP
DoCM (Curated mutations)ENPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ENPEP (select a term)
intoGenENPEP
Cancer3DENPEP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138297   
Orphanet
MedgenENPEP
Genetic Testing Registry ENPEP
NextProtQ07075 [Medical]
TSGene2028
GENETestsENPEP
Huge Navigator ENPEP [HugePedia]
snp3D : Map Gene to Disease2028
BioCentury BCIQENPEP
ClinGenENPEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2028
Chemical/Pharm GKB GenePA27790
Clinical trialENPEP
Miscellaneous
canSAR (ICR)ENPEP (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENPEP
EVEXENPEP
GoPubMedENPEP
iHOPENPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:36:40 CET 2016

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