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ENPEP (glutamyl aminopeptidase (aminopeptidase A))

Identity

Other namesAPA
CD249
gp160
HGNC (Hugo) ENPEP
LocusID (NCBI) 2028
Location 4q25
Location_base_pair Starts at 111397229 and ends at 111484493 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ENPEP   3355
Cards
Entrez_Gene (NCBI)ENPEP  2028  glutamyl aminopeptidase (aminopeptidase A)
GeneCards (Weizmann)ENPEP
Ensembl hg19 (Hinxton) [Gene_View]  chr4:111397229-111484493 [Contig_View]  ENPEP [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:111397229-111484493 [Contig_View]  ENPEP [Vega]
cBioPortalENPEP
AceView (NCBI)ENPEP
Genatlas (Paris)ENPEP
WikiGenes2028
SOURCE (Princeton)ENPEP
Genomic and cartography
GoldenPath hg19 (UCSC)ENPEP  -     chr4:111397229-111484493 +  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ENPEP  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblENPEP - 4q25 [CytoView hg19]  ENPEP - 4q25 [CytoView hg38]
Mapping of homologs : NCBIENPEP [Mapview hg19]  ENPEP [Mapview hg38]
OMIM138297   
Gene and transcription
Genbank (Entrez)AI640493 AK313412 AL568777 AM888273 AM888274
RefSeq transcript (Entrez)NM_001977
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838915 NW_004929320
Consensus coding sequences : CCDS (NCBI)ENPEP
Cluster EST : UnigeneHs.435765 [ NCBI ]
CGAP (NCI)Hs.435765
Alternative Splicing : Fast-db (Paris)GSHG0022789
Gene ExpressionENPEP [ NCBI-GEO ]     ENPEP [ SEEK ]   ENPEP [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07075 (Uniprot)
NextProtQ07075  [Medical]
With graphics : InterProQ07075
Splice isoforms : SwissVarQ07075 (Swissvar)
Catalytic activity : Enzyme3.4.11.7 [ Enzyme-Expasy ]   3.4.11.73.4.11.7 [ IntEnz-EBI ]   3.4.11.7 [ BRENDA ]   3.4.11.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    Peptidase_M1    Peptidase_M1_N   
Related proteins : CluSTrQ07075
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
DMDM Disease mutations2028
Blocks (Seattle)Q07075
PDB (SRS)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (PDBSum)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (IMB)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
PDB (RSDB)4KX7    4KX8    4KX9    4KXA    4KXB    4KXC    4KXD   
Peptide AtlasQ07075
HPRD08848
IPIIPI00014375   IPI00967998   
Protein Interaction databases
DIP (DOE-UCLA)Q07075
IntAct (EBI)Q07075
BioGRIDENPEP
IntegromeDBENPEP
STRING (EMBL)ENPEP
Ontologies - Pathways
QuickGOQ07075
Ontology : AmiGOangiogenesis  angiotensin maturation  angiotensin catabolic process in blood  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  aminopeptidase activity  lysosomal membrane  plasma membrane  integral component of plasma membrane  brush border  proteolysis  cell-cell signaling  metallopeptidase activity  zinc ion binding  cell proliferation  cell proliferation  external side of plasma membrane  apical plasma membrane  cell migration  cytoplasmic vesicle  glomerulus development  cellular protein metabolic process  apical part of cell  metalloaminopeptidase activity  metalloaminopeptidase activity  extracellular vesicular exosome  
Ontology : EGO-EBIangiogenesis  angiotensin maturation  angiotensin catabolic process in blood  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  aminopeptidase activity  lysosomal membrane  plasma membrane  integral component of plasma membrane  brush border  proteolysis  cell-cell signaling  metallopeptidase activity  zinc ion binding  cell proliferation  cell proliferation  external side of plasma membrane  apical plasma membrane  cell migration  cytoplasmic vesicle  glomerulus development  cellular protein metabolic process  apical part of cell  metalloaminopeptidase activity  metalloaminopeptidase activity  extracellular vesicular exosome  
Pathways : KEGGRenin-angiotensin system   
Protein Interaction DatabaseENPEP
DoCM (Curated mutations)ENPEP
Wikipedia pathwaysENPEP
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerENPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENPEP
dbVarENPEP
ClinVarENPEP
1000_GenomesENPEP 
Exome Variant ServerENPEP
SNP (GeneSNP Utah)ENPEP
SNP : HGBaseENPEP
Genetic variants : HAPMAPENPEP
Genomic VariantsENPEP  ENPEP [DGVbeta]
Mutations
Somatic Mutations in Cancer : COSMICENPEP 
CONAN: Copy Number AnalysisENPEP 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:111397229-111484493
Mutations and Diseases : HGMDENPEP
OMIM138297   
MedgenENPEP
NextProtQ07075 [Medical]
GENETestsENPEP
Disease Genetic AssociationENPEP
Huge Navigator ENPEP [HugePedia]  ENPEP [HugeCancerGEM]
snp3D : Map Gene to Disease2028
DGIdb (Drug Gene Interaction db)ENPEP
General knowledge
Homologs : HomoloGeneENPEP
Homology/Alignments : Family Browser (UCSC)ENPEP
Phylogenetic Trees/Animal Genes : TreeFamENPEP
Chemical/Protein Interactions : CTD2028
Chemical/Pharm GKB GenePA27790
Clinical trialENPEP
Other databases
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
CoreMineENPEP
GoPubMedENPEP
iHOPENPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:22:35 CET 2014

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