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ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative))

Identity

Alias_symbol (synonym)NPP4
KIAA0879
Other alias
HGNC (Hugo) ENPP4
LocusID (NCBI) 22875
Atlas_Id 62837
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 46097701 and ends at 46114436 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARID1B (6q25.3) / ENPP4 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ENPP4   3359
Cards
Entrez_Gene (NCBI)ENPP4  22875  ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
AliasesNPP4
GeneCards (Weizmann)ENPP4
Ensembl hg19 (Hinxton)ENSG00000001561 [Gene_View]  chr6:46097701-46114436 [Contig_View]  ENPP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000001561 [Gene_View]  chr6:46097701-46114436 [Contig_View]  ENPP4 [Vega]
ICGC DataPortalENSG00000001561
TCGA cBioPortalENPP4
AceView (NCBI)ENPP4
Genatlas (Paris)ENPP4
WikiGenes22875
SOURCE (Princeton)ENPP4
Genetics Home Reference (NIH)ENPP4
Genomic and cartography
GoldenPath hg19 (UCSC)ENPP4  -     chr6:46097701-46114436 +  6p21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ENPP4  -     6p21.1   [Description]    (hg38-Dec_2013)
EnsemblENPP4 - 6p21.1 [CytoView hg19]  ENPP4 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIENPP4 [Mapview hg19]  ENPP4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB020686 AJ420515 AK291276 BC018054 BI548305
RefSeq transcript (Entrez)NM_014936
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)ENPP4
Cluster EST : UnigeneHs.643497 [ NCBI ]
CGAP (NCI)Hs.643497
Alternative Splicing GalleryENSG00000001561
Gene ExpressionENPP4 [ NCBI-GEO ]   ENPP4 [ EBI - ARRAY_EXPRESS ]   ENPP4 [ SEEK ]   ENPP4 [ MEM ]
Gene Expression Viewer (FireBrowse)ENPP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22875
GTEX Portal (Tissue expression)ENPP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6X5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6X5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6X5
Splice isoforms : SwissVarQ9Y6X5
Catalytic activity : Enzyme3.6.1.29 [ Enzyme-Expasy ]   3.6.1.293.6.1.29 [ IntEnz-EBI ]   3.6.1.29 [ BRENDA ]   3.6.1.29 [ KEGG ]   
PhosPhoSitePlusQ9Y6X5
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase_core    E-NPP    ENPP4    Phosphodiest/P_Trfase   
Domain families : Pfam (Sanger)Phosphodiest (PF01663)   
Domain families : Pfam (NCBI)pfam01663   
Conserved Domain (NCBI)ENPP4
DMDM Disease mutations22875
Blocks (Seattle)ENPP4
PDB (SRS)4LQY    4LR2   
PDB (PDBSum)4LQY    4LR2   
PDB (IMB)4LQY    4LR2   
PDB (RSDB)4LQY    4LR2   
Structural Biology KnowledgeBase4LQY    4LR2   
SCOP (Structural Classification of Proteins)4LQY    4LR2   
CATH (Classification of proteins structures)4LQY    4LR2   
SuperfamilyQ9Y6X5
Human Protein AtlasENSG00000001561
Peptide AtlasQ9Y6X5
HPRD16862
IPIIPI00007249   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6X5
IntAct (EBI)Q9Y6X5
FunCoupENSG00000001561
BioGRIDENPP4
STRING (EMBL)ENPP4
ZODIACENPP4
Ontologies - Pathways
QuickGOQ9Y6X5
Ontology : AmiGOplasma membrane  blood coagulation  membrane  integral component of membrane  positive regulation of blood coagulation  purine ribonucleoside catabolic process  metal ion binding  bis(5'-adenosyl)-triphosphatase activity  extracellular exosome  
Ontology : EGO-EBIplasma membrane  blood coagulation  membrane  integral component of membrane  positive regulation of blood coagulation  purine ribonucleoside catabolic process  metal ion binding  bis(5'-adenosyl)-triphosphatase activity  extracellular exosome  
NDEx NetworkENPP4
Atlas of Cancer Signalling NetworkENPP4
Wikipedia pathwaysENPP4
Orthology - Evolution
OrthoDB22875
GeneTree (enSembl)ENSG00000001561
Phylogenetic Trees/Animal Genes : TreeFamENPP4
HOVERGENQ9Y6X5
HOGENOMQ9Y6X5
Homologs : HomoloGeneENPP4
Homology/Alignments : Family Browser (UCSC)ENPP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENPP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENPP4
dbVarENPP4
ClinVarENPP4
1000_GenomesENPP4 
Exome Variant ServerENPP4
ExAC (Exome Aggregation Consortium)ENPP4 (select the gene name)
Genetic variants : HAPMAP22875
Genomic Variants (DGV)ENPP4 [DGVbeta]
DECIPHER (Syndromes)6:46097701-46114436  ENSG00000001561
CONAN: Copy Number AnalysisENPP4 
Mutations
ICGC Data PortalENPP4 
TCGA Data PortalENPP4 
Broad Tumor PortalENPP4
OASIS PortalENPP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENPP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENPP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENPP4
DgiDB (Drug Gene Interaction Database)ENPP4
DoCM (Curated mutations)ENPP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ENPP4 (select a term)
intoGenENPP4
Cancer3DENPP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenENPP4
Genetic Testing Registry ENPP4
NextProtQ9Y6X5 [Medical]
TSGene22875
GENETestsENPP4
Huge Navigator ENPP4 [HugePedia]
snp3D : Map Gene to Disease22875
BioCentury BCIQENPP4
ClinGenENPP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22875
Chemical/Pharm GKB GenePA27794
Clinical trialENPP4
Miscellaneous
canSAR (ICR)ENPP4 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENPP4
EVEXENPP4
GoPubMedENPP4
iHOPENPP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:02:54 CET 2017

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