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ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6)

Identity

Alias_symbol (synonym)MGC33971
Other aliasNPP6
HGNC (Hugo) ENPP6
LocusID (NCBI) 133121
Atlas_Id 40456
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 185009859 and ends at 185139114 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ENPP6   23409
Cards
Entrez_Gene (NCBI)ENPP6  133121  ectonucleotide pyrophosphatase/phosphodiesterase 6
AliasesNPP6
GeneCards (Weizmann)ENPP6
Ensembl hg19 (Hinxton)ENSG00000164303 [Gene_View]  chr4:185009859-185139114 [Contig_View]  ENPP6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164303 [Gene_View]  chr4:185009859-185139114 [Contig_View]  ENPP6 [Vega]
ICGC DataPortalENSG00000164303
TCGA cBioPortalENPP6
AceView (NCBI)ENPP6
Genatlas (Paris)ENPP6
WikiGenes133121
SOURCE (Princeton)ENPP6
Genetics Home Reference (NIH)ENPP6
Genomic and cartography
GoldenPath hg19 (UCSC)ENPP6  -     chr4:185009859-185139114 -  4q35.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ENPP6  -     4q35.1   [Description]    (hg38-Dec_2013)
EnsemblENPP6 - 4q35.1 [CytoView hg19]  ENPP6 - 4q35.1 [CytoView hg38]
Mapping of homologs : NCBIENPP6 [Mapview hg19]  ENPP6 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK021943 AK057370 AK308585 AY358676 BC035035
RefSeq transcript (Entrez)NM_153343
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ENPP6
Cluster EST : UnigeneHs.297814 [ NCBI ]
CGAP (NCI)Hs.297814
Alternative Splicing GalleryENSG00000164303
Gene ExpressionENPP6 [ NCBI-GEO ]   ENPP6 [ EBI - ARRAY_EXPRESS ]   ENPP6 [ SEEK ]   ENPP6 [ MEM ]
Gene Expression Viewer (FireBrowse)ENPP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)133121
GTEX Portal (Tissue expression)ENPP6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UWR7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UWR7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UWR7
Splice isoforms : SwissVarQ6UWR7
Catalytic activity : Enzyme3.1.4.- [ Enzyme-Expasy ]   3.1.4.-3.1.4.- [ IntEnz-EBI ]   3.1.4.- [ BRENDA ]   3.1.4.- [ KEGG ]   
PhosPhoSitePlusQ6UWR7
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase_core    E-NPP    ENPP6    Phosphodiest/P_Trfase   
Domain families : Pfam (Sanger)Phosphodiest (PF01663)   
Domain families : Pfam (NCBI)pfam01663   
Conserved Domain (NCBI)ENPP6
DMDM Disease mutations133121
Blocks (Seattle)ENPP6
SuperfamilyQ6UWR7
Human Protein AtlasENSG00000164303
Peptide AtlasQ6UWR7
HPRD16863
IPIIPI00157414   IPI00965701   
Protein Interaction databases
DIP (DOE-UCLA)Q6UWR7
IntAct (EBI)Q6UWR7
FunCoupENSG00000164303
BioGRIDENPP6
STRING (EMBL)ENPP6
ZODIACENPP6
Ontologies - Pathways
QuickGOQ6UWR7
Ontology : AmiGOextracellular region  plasma membrane  plasma membrane  lipid metabolic process  phosphoric diester hydrolase activity  glycerophosphodiester phosphodiesterase activity  choline metabolic process  anchored component of membrane  glycerophospholipid catabolic process  glycerophosphocholine cholinephosphodiesterase activity  glycerophosphocholine cholinephosphodiesterase activity  extracellular exosome  
Ontology : EGO-EBIextracellular region  plasma membrane  plasma membrane  lipid metabolic process  phosphoric diester hydrolase activity  glycerophosphodiester phosphodiesterase activity  choline metabolic process  anchored component of membrane  glycerophospholipid catabolic process  glycerophosphocholine cholinephosphodiesterase activity  glycerophosphocholine cholinephosphodiesterase activity  extracellular exosome  
Pathways : KEGGEther lipid metabolism   
NDEx NetworkENPP6
Atlas of Cancer Signalling NetworkENPP6
Wikipedia pathwaysENPP6
Orthology - Evolution
OrthoDB133121
GeneTree (enSembl)ENSG00000164303
Phylogenetic Trees/Animal Genes : TreeFamENPP6
HOVERGENQ6UWR7
HOGENOMQ6UWR7
Homologs : HomoloGeneENPP6
Homology/Alignments : Family Browser (UCSC)ENPP6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENPP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENPP6
dbVarENPP6
ClinVarENPP6
1000_GenomesENPP6 
Exome Variant ServerENPP6
ExAC (Exome Aggregation Consortium)ENPP6 (select the gene name)
Genetic variants : HAPMAP133121
Genomic Variants (DGV)ENPP6 [DGVbeta]
DECIPHER (Syndromes)4:185009859-185139114  ENSG00000164303
CONAN: Copy Number AnalysisENPP6 
Mutations
ICGC Data PortalENPP6 
TCGA Data PortalENPP6 
Broad Tumor PortalENPP6
OASIS PortalENPP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENPP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENPP6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENPP6
DgiDB (Drug Gene Interaction Database)ENPP6
DoCM (Curated mutations)ENPP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ENPP6 (select a term)
intoGenENPP6
Cancer3DENPP6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenENPP6
Genetic Testing Registry ENPP6
NextProtQ6UWR7 [Medical]
TSGene133121
GENETestsENPP6
Huge Navigator ENPP6 [HugePedia]
snp3D : Map Gene to Disease133121
BioCentury BCIQENPP6
ClinGenENPP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD133121
Chemical/Pharm GKB GenePA134945118
Clinical trialENPP6
Miscellaneous
canSAR (ICR)ENPP6 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENPP6
EVEXENPP6
GoPubMedENPP6
iHOPENPP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:00:08 CEST 2017

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