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ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)

Identity

Alias_namesCD39
Alias_symbol (synonym)NTPDase-1
ATPDase
SPG64
Other alias
HGNC (Hugo) ENTPD1
LocusID (NCBI) 953
Atlas_Id 52440
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 95755916 and ends at 95877266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / ENTPD1 (10q24.1)BMPR1A (10q23.2) / ENTPD1 (10q24.1)ENTPD1 (10q24.1) / DGKH (13q14.11)
ENTPD1 (10q24.1) / ENTPD1 (10q24.1)ENTPD1 (10q24.1) / IKZF1 (7p12.2)ENTPD1 (10q24.1) / RPL13 (16q24.3)
PRKACA (19p13.12) / ENTPD1 (10q24.1)RTN4 (2p16.1) / ENTPD1 (10q24.1)BMPR1A 10q23.2 / ENTPD1 10q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q23;q24) BMPR1A/ENTPD1

External links

Nomenclature
HGNC (Hugo)ENTPD1   3363
Cards
Entrez_Gene (NCBI)ENTPD1  953  ectonucleoside triphosphate diphosphohydrolase 1
AliasesATPDase; CD39; NTPDase-1; SPG64
GeneCards (Weizmann)ENTPD1
Ensembl hg19 (Hinxton)ENSG00000138185 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138185 [Gene_View]  chr10:95755916-95877266 [Contig_View]  ENTPD1 [Vega]
ICGC DataPortalENSG00000138185
TCGA cBioPortalENTPD1
AceView (NCBI)ENTPD1
Genatlas (Paris)ENTPD1
WikiGenes953
SOURCE (Princeton)ENTPD1
Genetics Home Reference (NIH)ENTPD1
Genomic and cartography
GoldenPath hg38 (UCSC)ENTPD1  -     chr10:95755916-95877266 +  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ENTPD1  -     10q24.1   [Description]    (hg19-Feb_2009)
EnsemblENTPD1 - 10q24.1 [CytoView hg19]  ENTPD1 - 10q24.1 [CytoView hg38]
Mapping of homologs : NCBIENTPD1 [Mapview hg19]  ENTPD1 [Mapview hg38]
OMIM601752   615683   
Gene and transcription
Genbank (Entrez)AA748419 AJ133133 AJ133134 AK098240 AK098278
RefSeq transcript (Entrez)NM_001098175 NM_001164178 NM_001164179 NM_001164181 NM_001164182 NM_001164183 NM_001312654 NM_001320916 NM_001776
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ENTPD1
Cluster EST : UnigeneHs.722260 [ NCBI ]
CGAP (NCI)Hs.722260
Alternative Splicing GalleryENSG00000138185
Gene ExpressionENTPD1 [ NCBI-GEO ]   ENTPD1 [ EBI - ARRAY_EXPRESS ]   ENTPD1 [ SEEK ]   ENTPD1 [ MEM ]
Gene Expression Viewer (FireBrowse)ENTPD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)953
GTEX Portal (Tissue expression)ENTPD1
Human Protein AtlasENSG00000138185-ENTPD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49961   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49961  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49961
Splice isoforms : SwissVarP49961
Catalytic activity : Enzyme3.6.1.5 [ Enzyme-Expasy ]   3.6.1.53.6.1.5 [ IntEnz-EBI ]   3.6.1.5 [ BRENDA ]   3.6.1.5 [ KEGG ]   
PhosPhoSitePlusP49961
Domaine pattern : Prosite (Expaxy)GDA1_CD39_NTPASE (PS01238)   
Domains : Interpro (EBI)GDA1_CD39_NTPase   
Domain families : Pfam (Sanger)GDA1_CD39 (PF01150)   
Domain families : Pfam (NCBI)pfam01150   
Conserved Domain (NCBI)ENTPD1
DMDM Disease mutations953
Blocks (Seattle)ENTPD1
SuperfamilyP49961
Human Protein Atlas [tissue]ENSG00000138185-ENTPD1 [tissue]
Peptide AtlasP49961
HPRD09047
IPIIPI00382672   IPI00220852   IPI00220853   IPI00943652   IPI01012589   IPI00942421   IPI00943965   
Protein Interaction databases
DIP (DOE-UCLA)P49961
IntAct (EBI)P49961
FunCoupENSG00000138185
BioGRIDENTPD1
STRING (EMBL)ENTPD1
ZODIACENTPD1
Ontologies - Pathways
QuickGOP49961
Ontology : AmiGOprotein binding  ATP binding  plasma membrane  integral component of plasma membrane  cell adhesion  blood coagulation  membrane  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  nucleobase-containing small molecule catabolic process  extracellular exosome  dATP phosphohydrolase activity  dCTP phosphohydrolase activity  dUTP phosphohydrolase activity  dTTP phosphohydrolase activity  GTP phosphohydrolase activity  8-oxo-dGTP phosphohydrolase activity  dGTP phosphohydrolase activity  
Ontology : EGO-EBIprotein binding  ATP binding  plasma membrane  integral component of plasma membrane  cell adhesion  blood coagulation  membrane  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  nucleobase-containing small molecule catabolic process  extracellular exosome  dATP phosphohydrolase activity  dCTP phosphohydrolase activity  dUTP phosphohydrolase activity  dTTP phosphohydrolase activity  GTP phosphohydrolase activity  8-oxo-dGTP phosphohydrolase activity  dGTP phosphohydrolase activity  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism   
NDEx NetworkENTPD1
Atlas of Cancer Signalling NetworkENTPD1
Wikipedia pathwaysENTPD1
Orthology - Evolution
OrthoDB953
GeneTree (enSembl)ENSG00000138185
Phylogenetic Trees/Animal Genes : TreeFamENTPD1
HOVERGENP49961
HOGENOMP49961
Homologs : HomoloGeneENTPD1
Homology/Alignments : Family Browser (UCSC)ENTPD1
Gene fusions - Rearrangements
Fusion : MitelmanBMPR1A/ENTPD1 [10q23.2/10q24.1]  [t(10;10)(q23;q24)]  
Fusion: TCGA_MDACCBMPR1A 10q23.2 ENTPD1 10q24.1 PRAD
Fusion PortalBMPR1A 10q23.2 ENTPD1 10q24.1 PRAD
Fusion Cancer (Beijing)AD_1 [ENTPD1]  -  10q24.1 [FUSC002705]
Fusion : QuiverENTPD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENTPD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENTPD1
dbVarENTPD1
ClinVarENTPD1
1000_GenomesENTPD1 
Exome Variant ServerENTPD1
ExAC (Exome Aggregation Consortium)ENSG00000138185
GNOMAD BrowserENSG00000138185
Genetic variants : HAPMAP953
Genomic Variants (DGV)ENTPD1 [DGVbeta]
DECIPHERENTPD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisENTPD1 
Mutations
ICGC Data PortalENTPD1 
TCGA Data PortalENTPD1 
Broad Tumor PortalENTPD1
OASIS PortalENTPD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENTPD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENTPD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENTPD1
DgiDB (Drug Gene Interaction Database)ENTPD1
DoCM (Curated mutations)ENTPD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ENTPD1 (select a term)
intoGenENTPD1
Cancer3DENTPD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601752    615683   
Orphanet22833   
DisGeNETENTPD1
MedgenENTPD1
Genetic Testing Registry ENTPD1
NextProtP49961 [Medical]
TSGene953
GENETestsENTPD1
Target ValidationENTPD1
Huge Navigator ENTPD1 [HugePedia]
snp3D : Map Gene to Disease953
BioCentury BCIQENTPD1
ClinGenENTPD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD953
Chemical/Pharm GKB GenePA27798
Clinical trialENTPD1
Miscellaneous
canSAR (ICR)ENTPD1 (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENTPD1
EVEXENTPD1
GoPubMedENTPD1
iHOPENTPD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:11:20 CET 2018
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