ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)

2011-10-01 Affiliation

Identity

HGNC

ENTPD1

LOCATION

10q24.1

LOCUSID

953

ALIAS

ATPDase,CD39,NTPDase-1,SPG64

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 953
MIM: 601752
HGNC: 3363
Ensembl: ENSG00000138185

Variants:

dbSNP: 953
ClinVar: 953
TCGA: ENSG00000138185
COSMIC: ENTPD1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138185	ENST00000371205	P49961
ENSG00000138185	ENST00000371207	P49961
ENSG00000138185	ENST00000453258	P49961
ENSG00000138185	ENST00000483213	A0A0U1RR44
ENSG00000138185	ENST00000543964	P49961
ENSG00000138185	ENST00000635076	A0A0U1RQZ5
ENSG00000138185	ENST00000639992	A0A1W2PQK8

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Phosphate bond hydrolysis by NTPDase proteins	REACTOME	R-HSA-8850843

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17449799	2007	Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.	385
21677139	2011	Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.	139
18812468	2009	Central role of Sp1-regulated CD39 in hypoxia/ischemia protection.	90
20977632	2010	Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.	77
15146241	2004	Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.	73
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19450601	2009	Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression.	58
30006565	2018	Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.	58
18713747	2008	Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine.	53

Citation

Dessen P

ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52440/entpd1