ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2)

2015-08-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
CD39L1,NTPDase-2
FUSION GENES

Other Information

Locus ID:

NCBI: 954
MIM: 602012
HGNC: 3364
Ensembl: ENSG00000054179

Variants:

dbSNP: 954
ClinVar: 954
TCGA: ENSG00000054179
COSMIC: ENTPD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054179ENST00000312665Q9Y5L3
ENSG00000054179ENST00000355097Q9Y5L3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Taste transductionKEGGko04742
Purine metabolismKEGGhsa00230
Taste transductionKEGGhsa04742
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157999772005Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.45
288940872017Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.45
156512652004Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.17
154965022005Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2.14
128885622003Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.13
186569572008Inhibition of human NTPDase 2 by modification of an intramembrane cysteine by p-chloromercuriphenylsulfonate and oxidative cross-linking of the transmembrane domains.5
284722572017Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.4
174895622007Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2).3
292739162018Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity.2

Citation

Dessen P

ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55328/entpd2