Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

Identity

Alias (NCBI)LALP70
LAP70
LYSAL1
NTPDase-4
UDPase
HGNC (Hugo) ENTPD4
HGNC Alias symbLALP70
LAP70
KIAA0392
NTPDase-4
UDPase
HGNC Previous nameLYSAL1
HGNC Previous namelysosomal apyrase-like 1
LocusID (NCBI) 9583
Atlas_Id 62845
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 23429162 and ends at 23457647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C14orf37 (14q23.1) / ENTPD4 (8p21.3)C17orf62 (17q25.3) / ENTPD4 (8p21.3)CNOT1 (16q21) / ENTPD4 (8p21.3)
ENTPD4 (8p21.3) / ENTPD4 (8p21.3)ENTPD4 (8p21.3) / LOXL2 (8p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(8;8)(p21;p22) ENTPD4/PSD3
t(8;8)(p21;p22) ENTPD4/PSD3


External links

 

Nomenclature
HGNC (Hugo)ENTPD4   14573
Cards
Entrez_Gene (NCBI)ENTPD4    ectonucleoside triphosphate diphosphohydrolase 4
AliasesLALP70; LAP70; LYSAL1; NTPDase-4; 
UDPase
GeneCards (Weizmann)ENTPD4
Ensembl hg19 (Hinxton)ENSG00000197217 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197217 [Gene_View]  ENSG00000197217 [Sequence]  chr8:23429162-23457647 [Contig_View]  ENTPD4 [Vega]
ICGC DataPortalENSG00000197217
TCGA cBioPortalENTPD4
AceView (NCBI)ENTPD4
Genatlas (Paris)ENTPD4
SOURCE (Princeton)ENTPD4
Genetics Home Reference (NIH)ENTPD4
Genomic and cartography
GoldenPath hg38 (UCSC)ENTPD4  -     chr8:23429162-23457647 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ENTPD4  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathENTPD4 - 8p21.3 [CytoView hg19]  ENTPD4 - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000197217
Genome Data Viewer NCBIENTPD4 [Mapview hg19]  
OMIM607577   
Gene and transcription
Genbank (Entrez)AB002390 AF016032 AJ131358 AK300464 BC034477
RefSeq transcript (Entrez)NM_001128930 NM_004901
Consensus coding sequences : CCDS (NCBI)ENTPD4
Gene ExpressionENTPD4 [ NCBI-GEO ]   ENTPD4 [ EBI - ARRAY_EXPRESS ]   ENTPD4 [ SEEK ]   ENTPD4 [ MEM ]
Gene Expression Viewer (FireBrowse)ENTPD4 [ Firebrowse - Broad ]
GenevisibleExpression of ENTPD4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9583
GTEX Portal (Tissue expression)ENTPD4
Human Protein AtlasENSG00000197217-ENTPD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y227   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y227  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y227
PhosPhoSitePlusQ9Y227
Domaine pattern : Prosite (Expaxy)GDA1_CD39_NTPASE (PS01238)   
Domains : Interpro (EBI)GDA1_CD39_NTPase   
Domain families : Pfam (Sanger)GDA1_CD39 (PF01150)   
Domain families : Pfam (NCBI)pfam01150   
Conserved Domain (NCBI)ENTPD4
PDB (RSDB)6WG5   
PDB Europe6WG5   
PDB (PDBSum)6WG5   
PDB (IMB)6WG5   
Structural Biology KnowledgeBase6WG5   
SCOP (Structural Classification of Proteins)6WG5   
CATH (Classification of proteins structures)6WG5   
SuperfamilyQ9Y227
AlphaFold pdb e-kbQ9Y227   
Human Protein Atlas [tissue]ENSG00000197217-ENTPD4 [tissue]
HPRD09618
Protein Interaction databases
DIP (DOE-UCLA)Q9Y227
IntAct (EBI)Q9Y227
BioGRIDENTPD4
STRING (EMBL)ENTPD4
ZODIACENTPD4
Ontologies - Pathways
QuickGOQ9Y227
Ontology : AmiGOGolgi membrane  GTPase activity  guanosine-diphosphatase activity  guanosine-diphosphatase activity  lysosomal membrane  Golgi apparatus  UDP catabolic process  UDP catabolic process  nucleoside diphosphate catabolic process  membrane  nucleoside-diphosphatase activity  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  integral component of Golgi membrane  cytoplasmic vesicle  nucleobase-containing small molecule catabolic process  nucleobase-containing small molecule catabolic process  cytidine-diphosphatase activity  CTPase activity  uridine-diphosphatase activity  uridine-diphosphatase activity  CTP metabolic process  GDP catabolic process  integral component of autophagosome membrane  
Ontology : EGO-EBIGolgi membrane  GTPase activity  guanosine-diphosphatase activity  guanosine-diphosphatase activity  lysosomal membrane  Golgi apparatus  UDP catabolic process  UDP catabolic process  nucleoside diphosphate catabolic process  membrane  nucleoside-diphosphatase activity  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  integral component of Golgi membrane  cytoplasmic vesicle  nucleobase-containing small molecule catabolic process  nucleobase-containing small molecule catabolic process  cytidine-diphosphatase activity  CTPase activity  uridine-diphosphatase activity  uridine-diphosphatase activity  CTP metabolic process  GDP catabolic process  integral component of autophagosome membrane  
Pathways : KEGGPyrimidine metabolism    Purine metabolism   
NDEx NetworkENTPD4
Atlas of Cancer Signalling NetworkENTPD4
Wikipedia pathwaysENTPD4
Orthology - Evolution
OrthoDB9583
GeneTree (enSembl)ENSG00000197217
Phylogenetic Trees/Animal Genes : TreeFamENTPD4
Homologs : HomoloGeneENTPD4
Homology/Alignments : Family Browser (UCSC)ENTPD4
Gene fusions - Rearrangements
Fusion : QuiverENTPD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENTPD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENTPD4
dbVarENTPD4
ClinVarENTPD4
MonarchENTPD4
1000_GenomesENTPD4 
Exome Variant ServerENTPD4
GNOMAD BrowserENSG00000197217
Varsome BrowserENTPD4
ACMGENTPD4 variants
VarityQ9Y227
Genomic Variants (DGV)ENTPD4 [DGVbeta]
DECIPHERENTPD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisENTPD4 
Mutations
ICGC Data PortalENTPD4 
TCGA Data PortalENTPD4 
Broad Tumor PortalENTPD4
OASIS PortalENTPD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENTPD4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DENTPD4
Mutations and Diseases : HGMDENTPD4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaENTPD4
DgiDB (Drug Gene Interaction Database)ENTPD4
DoCM (Curated mutations)ENTPD4
CIViC (Clinical Interpretations of Variants in Cancer)ENTPD4
Cancer3DENTPD4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607577   
Orphanet
DisGeNETENTPD4
MedgenENTPD4
Genetic Testing Registry ENTPD4
NextProtQ9Y227 [Medical]
GENETestsENTPD4
Target ValidationENTPD4
Huge Navigator ENTPD4 [HugePedia]
ClinGenENTPD4
Clinical trials, drugs, therapy
MyCancerGenomeENTPD4
Protein Interactions : CTDENTPD4
Pharm GKB GenePA30502
PharosQ9Y227
Clinical trialENTPD4
Miscellaneous
canSAR (ICR)ENTPD4
HarmonizomeENTPD4
DataMed IndexENTPD4
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXENTPD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:48:58 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.