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ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

Identity

Alias_namesLYSAL1
lysosomal apyrase-like 1
Alias_symbol (synonym)LALP70
LAP70
KIAA0392
NTPDase-4
UDPase
Other alias
HGNC (Hugo) ENTPD4
LocusID (NCBI) 9583
Atlas_Id 62845
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 23429152 and ends at 23457731 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C14orf37 (14q23.1) / ENTPD4 (8p21.3)C17orf62 (17q25.3) / ENTPD4 (8p21.3)CNOT1 (16q21) / ENTPD4 (8p21.3)
ENTPD4 (8p21.3) / ENTPD4 (8p21.3)ENTPD4 (8p21.3) / LOXL2 (8p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ENTPD4   14573
Cards
Entrez_Gene (NCBI)ENTPD4  9583  ectonucleoside triphosphate diphosphohydrolase 4
AliasesLALP70; LAP70; LYSAL1; NTPDase-4; 
UDPase
GeneCards (Weizmann)ENTPD4
Ensembl hg19 (Hinxton)ENSG00000197217 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197217 [Gene_View]  chr8:23429152-23457731 [Contig_View]  ENTPD4 [Vega]
ICGC DataPortalENSG00000197217
TCGA cBioPortalENTPD4
AceView (NCBI)ENTPD4
Genatlas (Paris)ENTPD4
WikiGenes9583
SOURCE (Princeton)ENTPD4
Genetics Home Reference (NIH)ENTPD4
Genomic and cartography
GoldenPath hg38 (UCSC)ENTPD4  -     chr8:23429152-23457731 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ENTPD4  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblENTPD4 - 8p21.3 [CytoView hg19]  ENTPD4 - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBIENTPD4 [Mapview hg19]  ENTPD4 [Mapview hg38]
OMIM607577   
Gene and transcription
Genbank (Entrez)AB002390 AF016032 AJ131358 AK300464 BC034477
RefSeq transcript (Entrez)NM_001128930 NM_004901
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ENTPD4
Cluster EST : UnigeneHs.444389 [ NCBI ]
CGAP (NCI)Hs.444389
Alternative Splicing GalleryENSG00000197217
Gene ExpressionENTPD4 [ NCBI-GEO ]   ENTPD4 [ EBI - ARRAY_EXPRESS ]   ENTPD4 [ SEEK ]   ENTPD4 [ MEM ]
Gene Expression Viewer (FireBrowse)ENTPD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9583
GTEX Portal (Tissue expression)ENTPD4
Human Protein AtlasENSG00000197217-ENTPD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y227   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y227  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y227
Splice isoforms : SwissVarQ9Y227
Catalytic activity : Enzyme3.6.1.6 [ Enzyme-Expasy ]   3.6.1.63.6.1.6 [ IntEnz-EBI ]   3.6.1.6 [ BRENDA ]   3.6.1.6 [ KEGG ]   
PhosPhoSitePlusQ9Y227
Domaine pattern : Prosite (Expaxy)GDA1_CD39_NTPASE (PS01238)   
Domains : Interpro (EBI)GDA1_CD39_NTPase   
Domain families : Pfam (Sanger)GDA1_CD39 (PF01150)   
Domain families : Pfam (NCBI)pfam01150   
Conserved Domain (NCBI)ENTPD4
DMDM Disease mutations9583
Blocks (Seattle)ENTPD4
SuperfamilyQ9Y227
Human Protein Atlas [tissue]ENSG00000197217-ENTPD4 [tissue]
Peptide AtlasQ9Y227
HPRD09618
IPIIPI00031718   IPI00219085   IPI00981245   IPI00168612   IPI00984986   IPI00980670   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y227
IntAct (EBI)Q9Y227
FunCoupENSG00000197217
BioGRIDENTPD4
STRING (EMBL)ENTPD4
ZODIACENTPD4
Ontologies - Pathways
QuickGOQ9Y227
Ontology : AmiGOGolgi membrane  UDP catabolic process  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  integral component of Golgi membrane  cytoplasmic vesicle  uridine-diphosphatase activity  nucleobase-containing small molecule metabolic process  integral component of autophagosome membrane  
Ontology : EGO-EBIGolgi membrane  UDP catabolic process  nucleoside-diphosphatase activity  nucleoside-triphosphatase activity  integral component of Golgi membrane  cytoplasmic vesicle  uridine-diphosphatase activity  nucleobase-containing small molecule metabolic process  integral component of autophagosome membrane  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    Lysosome   
NDEx NetworkENTPD4
Atlas of Cancer Signalling NetworkENTPD4
Wikipedia pathwaysENTPD4
Orthology - Evolution
OrthoDB9583
GeneTree (enSembl)ENSG00000197217
Phylogenetic Trees/Animal Genes : TreeFamENTPD4
HOVERGENQ9Y227
HOGENOMQ9Y227
Homologs : HomoloGeneENTPD4
Homology/Alignments : Family Browser (UCSC)ENTPD4
Gene fusions - Rearrangements
Tumor Fusion PortalENTPD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerENTPD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ENTPD4
dbVarENTPD4
ClinVarENTPD4
1000_GenomesENTPD4 
Exome Variant ServerENTPD4
ExAC (Exome Aggregation Consortium)ENSG00000197217
GNOMAD BrowserENSG00000197217
Genetic variants : HAPMAP9583
Genomic Variants (DGV)ENTPD4 [DGVbeta]
DECIPHERENTPD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisENTPD4 
Mutations
ICGC Data PortalENTPD4 
TCGA Data PortalENTPD4 
Broad Tumor PortalENTPD4
OASIS PortalENTPD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICENTPD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDENTPD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ENTPD4
DgiDB (Drug Gene Interaction Database)ENTPD4
DoCM (Curated mutations)ENTPD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ENTPD4 (select a term)
intoGenENTPD4
Cancer3DENTPD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607577   
Orphanet
DisGeNETENTPD4
MedgenENTPD4
Genetic Testing Registry ENTPD4
NextProtQ9Y227 [Medical]
TSGene9583
GENETestsENTPD4
Target ValidationENTPD4
Huge Navigator ENTPD4 [HugePedia]
snp3D : Map Gene to Disease9583
BioCentury BCIQENTPD4
ClinGenENTPD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9583
Chemical/Pharm GKB GenePA30502
Clinical trialENTPD4
Miscellaneous
canSAR (ICR)ENTPD4 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineENTPD4
EVEXENTPD4
GoPubMedENTPD4
iHOPENTPD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:18:06 CET 2017

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