ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

2014-11-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
LALP70,LAP70,LYSAL1,NTPDase-4,UDPase
FUSION GENES

Other Information

Locus ID:

NCBI: 9583
MIM: 607577
HGNC: 14573
Ensembl: ENSG00000197217

Variants:

dbSNP: 9583
ClinVar: 9583
TCGA: ENSG00000197217
COSMIC: ENTPD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197217ENST00000356206Q8NE73
ENSG00000197217ENST00000358689Q9Y227
ENSG00000197217ENST00000417069Q9Y227
ENSG00000197217ENST00000518471H0YBY8
ENSG00000197217ENST00000518718E5RIB2
ENSG00000197217ENST00000519839H0YAN2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
LysosomeKEGGko04142
LysosomeKEGGhsa04142
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.4
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.4
246720252014NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.4
152006862004The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70.3

Citation

Dessen P

ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62845/entpd4