Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EOMES (eomesodermin)

Identity

Alias_nameseomesodermin (Xenopus laevis) homolog
Alias_symbol (synonym)TBR2
Other alias
HGNC (Hugo) EOMES
LocusID (NCBI) 8320
Atlas_Id 53445
Location 3p24.1  [Link to chromosome band 3p24]
Location_base_pair Starts at 27715949 and ends at 27722715 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EOMES (3p24.1) / SLC4A7 (3p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)EOMES   3372
Cards
Entrez_Gene (NCBI)EOMES  8320  eomesodermin
AliasesTBR2
GeneCards (Weizmann)EOMES
Ensembl hg19 (Hinxton)ENSG00000163508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163508 [Gene_View]  chr3:27715949-27722715 [Contig_View]  EOMES [Vega]
ICGC DataPortalENSG00000163508
TCGA cBioPortalEOMES
AceView (NCBI)EOMES
Genatlas (Paris)EOMES
WikiGenes8320
SOURCE (Princeton)EOMES
Genetics Home Reference (NIH)EOMES
Genomic and cartography
GoldenPath hg38 (UCSC)EOMES  -     chr3:27715949-27722715 -  3p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EOMES  -     3p24.1   [Description]    (hg19-Feb_2009)
EnsemblEOMES - 3p24.1 [CytoView hg19]  EOMES - 3p24.1 [CytoView hg38]
Mapping of homologs : NCBIEOMES [Mapview hg19]  EOMES [Mapview hg38]
OMIM604615   
Gene and transcription
Genbank (Entrez)AB031038 AK297389 AK297461 AK299499 AK299695
RefSeq transcript (Entrez)NM_001278182 NM_001278183 NM_005442
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EOMES
Cluster EST : UnigeneHs.734211 [ NCBI ]
CGAP (NCI)Hs.734211
Alternative Splicing GalleryENSG00000163508
Gene ExpressionEOMES [ NCBI-GEO ]   EOMES [ EBI - ARRAY_EXPRESS ]   EOMES [ SEEK ]   EOMES [ MEM ]
Gene Expression Viewer (FireBrowse)EOMES [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8320
GTEX Portal (Tissue expression)EOMES
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95936   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95936  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95936
Splice isoforms : SwissVarO95936
PhosPhoSitePlusO95936
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_assoc    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)    T-box_assoc (PF16176)   
Domain families : Pfam (NCBI)pfam00907    pfam16176   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)EOMES
DMDM Disease mutations8320
Blocks (Seattle)EOMES
SuperfamilyO95936
Human Protein AtlasENSG00000163508
Peptide AtlasO95936
HPRD07054
IPIIPI00296036   IPI00922382   IPI01009193   IPI00789239   
Protein Interaction databases
DIP (DOE-UCLA)O95936
IntAct (EBI)O95936
FunCoupENSG00000163508
BioGRIDEOMES
STRING (EMBL)EOMES
ZODIACEOMES
Ontologies - Pathways
QuickGOO95936
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  transcriptional repressor activity, RNA polymerase II transcription factor binding  endoderm formation  mesoderm formation  endodermal cell fate specification  trophectodermal cell differentiation  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  brain development  cardioblast differentiation  stem cell population maintenance  olfactory bulb development  cerebral cortex regionalization  cerebral cortex neuron differentiation  interferon-gamma production  skeletal muscle cell differentiation  sequence-specific DNA binding  positive regulation of cell differentiation  regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  cell differentiation involved in embryonic placenta development  mesodermal to mesenchymal transition involved in gastrulation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  transcriptional repressor activity, RNA polymerase II transcription factor binding  endoderm formation  mesoderm formation  endodermal cell fate specification  trophectodermal cell differentiation  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  nucleus  transcription, DNA-templated  brain development  cardioblast differentiation  stem cell population maintenance  olfactory bulb development  cerebral cortex regionalization  cerebral cortex neuron differentiation  interferon-gamma production  skeletal muscle cell differentiation  sequence-specific DNA binding  positive regulation of cell differentiation  regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  cell differentiation involved in embryonic placenta development  mesodermal to mesenchymal transition involved in gastrulation  
NDEx NetworkEOMES
Atlas of Cancer Signalling NetworkEOMES
Wikipedia pathwaysEOMES
Orthology - Evolution
OrthoDB8320
GeneTree (enSembl)ENSG00000163508
Phylogenetic Trees/Animal Genes : TreeFamEOMES
HOVERGENO95936
HOGENOMO95936
Homologs : HomoloGeneEOMES
Homology/Alignments : Family Browser (UCSC)EOMES
Gene fusions - Rearrangements
Fusion : MitelmanEOMES/SLC4A7 [3p24.1/3p24.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEOMES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EOMES
dbVarEOMES
ClinVarEOMES
1000_GenomesEOMES 
Exome Variant ServerEOMES
ExAC (Exome Aggregation Consortium)EOMES (select the gene name)
Genetic variants : HAPMAP8320
Genomic Variants (DGV)EOMES [DGVbeta]
DECIPHEREOMES [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEOMES 
Mutations
ICGC Data PortalEOMES 
TCGA Data PortalEOMES 
Broad Tumor PortalEOMES
OASIS PortalEOMES [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEOMES  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEOMES
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EOMES
DgiDB (Drug Gene Interaction Database)EOMES
DoCM (Curated mutations)EOMES (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EOMES (select a term)
intoGenEOMES
Cancer3DEOMES(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604615   
Orphanet17930   
MedgenEOMES
Genetic Testing Registry EOMES
NextProtO95936 [Medical]
TSGene8320
GENETestsEOMES
Target ValidationEOMES
Huge Navigator EOMES [HugePedia]
snp3D : Map Gene to Disease8320
BioCentury BCIQEOMES
ClinGenEOMES
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8320
Chemical/Pharm GKB GenePA27806
Clinical trialEOMES
Miscellaneous
canSAR (ICR)EOMES (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEOMES
EVEXEOMES
GoPubMedEOMES
iHOPEOMES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:00:29 CEST 2017

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