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EOMES (eomesodermin)

Identity

Alias (NCBI)TBR2
HGNC (Hugo) EOMES
HGNC Alias symbTBR2
HGNC Alias nameT-box brain2
HGNC Previous nameeomesodermin (Xenopus laevis) homolog
LocusID (NCBI) 8320
Atlas_Id 53445
Location 3p24.1  [Link to chromosome band 3p24]
Location_base_pair Starts at 27715953 and ends at 27722323 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EOMES (3p24.1) / SLC4A7 (3p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EOMES   3372
Cards
Entrez_Gene (NCBI)EOMES    eomesodermin
AliasesTBR2
GeneCards (Weizmann)EOMES
Ensembl hg19 (Hinxton)ENSG00000163508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163508 [Gene_View]  ENSG00000163508 [Sequence]  chr3:27715953-27722323 [Contig_View]  EOMES [Vega]
ICGC DataPortalENSG00000163508
TCGA cBioPortalEOMES
AceView (NCBI)EOMES
Genatlas (Paris)EOMES
SOURCE (Princeton)EOMES
Genetics Home Reference (NIH)EOMES
Genomic and cartography
GoldenPath hg38 (UCSC)EOMES  -     chr3:27715953-27722323 -  3p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EOMES  -     3p24.1   [Description]    (hg19-Feb_2009)
GoldenPathEOMES - 3p24.1 [CytoView hg19]  EOMES - 3p24.1 [CytoView hg38]
ImmunoBaseENSG00000163508
Genome Data Viewer NCBIEOMES [Mapview hg19]  
OMIM604615   
Gene and transcription
Genbank (Entrez)AB031038 AK297389 AK297461 AK299499 AK299695
RefSeq transcript (Entrez)NM_001278182 NM_001278183 NM_005442
Consensus coding sequences : CCDS (NCBI)EOMES
Gene ExpressionEOMES [ NCBI-GEO ]   EOMES [ EBI - ARRAY_EXPRESS ]   EOMES [ SEEK ]   EOMES [ MEM ]
Gene Expression Viewer (FireBrowse)EOMES [ Firebrowse - Broad ]
GenevisibleExpression of EOMES in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8320
GTEX Portal (Tissue expression)EOMES
Human Protein AtlasENSG00000163508-EOMES [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95936   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95936  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95936
PhosPhoSitePlusO95936
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_assoc    T-box_sf    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)    T-box_assoc (PF16176)   
Domain families : Pfam (NCBI)pfam00907    pfam16176   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)EOMES
SuperfamilyO95936
AlphaFold pdb e-kbO95936   
Human Protein Atlas [tissue]ENSG00000163508-EOMES [tissue]
HPRD07054
Protein Interaction databases
DIP (DOE-UCLA)O95936
IntAct (EBI)O95936
BioGRIDEOMES
STRING (EMBL)EOMES
ZODIACEOMES
Ontologies - Pathways
QuickGOO95936
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  endoderm formation  mesoderm formation  mesoderm formation  cell fate specification  endodermal cell fate specification  heart looping  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  DNA binding  nucleus  regulation of transcription by RNA polymerase II  brain development  negative regulation of DNA-binding transcription factor activity  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  cell differentiation involved in embryonic placenta development  mesodermal to mesenchymal transition involved in gastrulation  RNA polymerase II-specific DNA-binding transcription factor binding  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  endoderm formation  mesoderm formation  mesoderm formation  cell fate specification  endodermal cell fate specification  heart looping  adaptive immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  CD8-positive, alpha-beta T cell differentiation involved in immune response  DNA binding  nucleus  regulation of transcription by RNA polymerase II  brain development  negative regulation of DNA-binding transcription factor activity  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  cell differentiation involved in embryonic placenta development  mesodermal to mesenchymal transition involved in gastrulation  RNA polymerase II-specific DNA-binding transcription factor binding  sequence-specific double-stranded DNA binding  
NDEx NetworkEOMES
Atlas of Cancer Signalling NetworkEOMES
Wikipedia pathwaysEOMES
Orthology - Evolution
OrthoDB8320
GeneTree (enSembl)ENSG00000163508
Phylogenetic Trees/Animal Genes : TreeFamEOMES
Homologs : HomoloGeneEOMES
Homology/Alignments : Family Browser (UCSC)EOMES
Gene fusions - Rearrangements
Fusion : MitelmanEOMES/SLC4A7 [3p24.1/3p24.1]  
Fusion : QuiverEOMES
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEOMES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EOMES
dbVarEOMES
ClinVarEOMES
MonarchEOMES
1000_GenomesEOMES 
Exome Variant ServerEOMES
GNOMAD BrowserENSG00000163508
Varsome BrowserEOMES
ACMGEOMES variants
VarityO95936
Genomic Variants (DGV)EOMES [DGVbeta]
DECIPHEREOMES [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEOMES 
Mutations
ICGC Data PortalEOMES 
TCGA Data PortalEOMES 
Broad Tumor PortalEOMES
OASIS PortalEOMES [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEOMES  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEOMES
Mutations and Diseases : HGMDEOMES
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEOMES
DgiDB (Drug Gene Interaction Database)EOMES
DoCM (Curated mutations)EOMES
CIViC (Clinical Interpretations of Variants in Cancer)EOMES
Cancer3DEOMES
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604615   
Orphanet17930   
DisGeNETEOMES
MedgenEOMES
Genetic Testing Registry EOMES
NextProtO95936 [Medical]
GENETestsEOMES
Target ValidationEOMES
Huge Navigator EOMES [HugePedia]
ClinGenEOMES
Clinical trials, drugs, therapy
MyCancerGenomeEOMES
Protein Interactions : CTDEOMES
Pharm GKB GenePA27806
PharosO95936
Clinical trialEOMES
Miscellaneous
canSAR (ICR)EOMES
HarmonizomeEOMES
DataMed IndexEOMES
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEOMES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:15 CEST 2021

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