EPC1 (enhancer of polycomb homolog 1)

2006-08-01  

Identity

HGNC
LOCATION
10p11.22
LOCUSID
ALIAS
Epl1
FUSION GENES

Other Information

Locus ID:

NCBI: 80314
MIM: 610999
HGNC: 19876
Ensembl: ENSG00000120616

Variants:

dbSNP: 80314
ClinVar: 80314
TCGA: ENSG00000120616
COSMIC: EPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120616ENST00000263062Q9H2F5
ENSG00000120616ENST00000319778Q9H2F5
ENSG00000120616ENST00000375110Q9H2F5
ENSG00000120616ENST00000469059A0A590UJ87
ENSG00000120616ENST00000480402A0A590UJ89
ENSG00000120616ENST00000667706A0A590UJN0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
171922672007Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.24
194847612009Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.14
241662972014Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.12
189846742009KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.8
263502152016Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.8
257557232015RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.1

Citation

Dessen P

EPC1 (enhancer of polycomb homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-08-01

Online version: http://atlasgeneticsoncology.org/gene/42977/epc1