Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EPHA4 (EPH receptor A4)

Identity

Other namesHEK8
SEK
TYRO1
HGNC (Hugo) EPHA4
LocusID (NCBI) 2043
Location 2q36.1
Location_base_pair Starts at 222282747 and ends at 222437010 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHA4   3388
Entrez_Gene (NCBI)EPHA4  2043  EPH receptor A4
Cards
GeneCards (Weizmann)EPHA4
Ensembl (Hinxton)ENSG00000116106 [Gene_View]  chr2:222282747-222437010 [Contig_View]  EPHA4 [Vega]
AceView (NCBI)EPHA4
Genatlas (Paris)EPHA4
SOURCE (Stanford)NM_004438
Genomic and cartography
GoldenPath (UCSC)EPHA4  -  2q36.1   chr2:222282747-222437010 -  2q36.1   [Description]    (hg19-Feb_2009)
EnsemblEPHA4 - 2q36.1 [CytoView]
Mapping of homologs : NCBIEPHA4 [Mapview]
OMIM602188   
Gene and transcription
Genbank (Entrez)AA987900 AF075040 AK225181 AK290306 AK300772
RefSeq transcript (SRS)NM_004438
RefSeq transcript (Entrez)NM_004438
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838865 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838865 NW_004078008
Consensus coding sequences : CCDS (NCBI)EPHA4
Cluster EST : UnigeneHs.371218 [ SRS ] Hs.371218 [ NCBI ]
CGAP (NCI)Hs.371218
Alternative Splicing : Fast-db (Paris)GSHG0018369
Alternative Splicing GalleryENSG00000116106
Gene ExpressionEPHA4 [ NCBI-GEO ]   EPHA4 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54764 (SRS) P54764 (Uniprot)
NextProtP54764
With graphics : InterProP54764
Splice isoforms : SwissVarP54764(Swissvar)
Domaine pattern : Prosite (SRS)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domaine pattern : Prosite (Expaxy)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (SRS)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_2    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domains : Interpro (EBI)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_2    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54764
Domain families : Pfam (SRS)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_2 (PF07647)   
Domain families : Pfam (Sanger)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam01404    pfam00041    pfam07714    pfam07647   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM2043
Blocks (Seattle)P54764
PDB (SRS)2WO1    2WO2    2WO3    3CKH    3GXU   
PDB (PDBSum)2WO1    2WO2    2WO3    3CKH    3GXU   
PDB (IMB)2WO1    2WO2    2WO3    3CKH    3GXU   
PDB (RSDB)2WO1    2WO2    2WO3    3CKH    3GXU   
Human Protein AtlasENSG00000116106
HPRD03719
IPIIPI00008318   IPI00916323   IPI00386267   IPI01010592   IPI00917056   IPI00916754   IPI00916447   IPI00916092   IPI00917445   IPI00916972   
Protein Interaction databases
DIP (DOE-UCLA)P54764
IntAct (EBI)P54764
FunCoupENSG00000116106
REACTOMEEPHA4
Protein Interaction Database2043
BioGRIDEPHA4
InParanoidP54764
Interologous Interaction database P54764
IntegromeDBEPHA4
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EPHA4
SNP (GeneSNP Utah)EPHA4
SNP : HGBaseEPHA4
Genetic variants : HAPMAPEPHA4
Somatic Mutations in Cancer : COSMICEPHA4 
CONAN: Copy Number AnalysisEPHA4 
Mutations and Diseases : HGMDEPHA4
OMIM602188   
GENETests602188   
Disease Genetic AssociationEPHA4
Huge Navigator EPHA4 [HugePedia]  EPHA4 [HugeCancerGEM]
Genomic VariantsEPHA4  EPHA4 [DGVbeta]
snp3D : Map Gene to Disease2043
General knowledge
Homologs : HomoloGeneEPHA4
Homology/Alignments : Family Browser (UCSC)EPHA4
Phylogenetic Trees/Animal Genes : TreeFamEPHA4
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD2043
Chemical/Pharm GKB GenePA27820
Clinical trialEPHA4
Cancer Resource (Charite)ENSG00000116106
Ontology : AmiGOprotein kinase activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  protein binding  ATP binding  cytoplasm  integral to plasma membrane  cell adhesion  adult walking behavior  motor neuron axon guidance  postsynaptic density  peptidyl-tyrosine phosphorylation  corticospinal tract morphogenesis  cell junction  axon  dendrite  neuromuscular junction  early endosome membrane  regulation of Rac GTPase activity  regulation of Rap GTPase activity  PH domain binding  positive regulation of JUN kinase activity  postsynaptic membrane  protein autophosphorylation  ephrin receptor binding  negative regulation of axon regeneration  regulation of astrocyte differentiation  regulation of axonogenesis  regulation of dendritic spine morphogenesis  fasciculation of sensory neuron axon  fasciculation of motor neuron axon  DH domain binding  positive regulation of Rho guanyl-nucleotide exchange factor activity  
Ontology : EGO-EBIprotein kinase activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  protein binding  ATP binding  cytoplasm  integral to plasma membrane  cell adhesion  adult walking behavior  motor neuron axon guidance  postsynaptic density  peptidyl-tyrosine phosphorylation  corticospinal tract morphogenesis  cell junction  axon  dendrite  neuromuscular junction  early endosome membrane  regulation of Rac GTPase activity  regulation of Rap GTPase activity  PH domain binding  positive regulation of JUN kinase activity  postsynaptic membrane  protein autophosphorylation  ephrin receptor binding  negative regulation of axon regeneration  regulation of astrocyte differentiation  regulation of axonogenesis  regulation of dendritic spine morphogenesis  fasciculation of sensory neuron axon  fasciculation of motor neuron axon  DH domain binding  positive regulation of Rho guanyl-nucleotide exchange factor activity  
Pathways : BIOCARTAEph Kinases and ephrins support platelet aggregation [Genes]   
Pathways : KEGGAxon guidance
Other databases
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
PubGeneEPHA4
iHOPEPHA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:18:25 CEST 2013
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