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EPHA4 (EPH receptor A4)

Identity

Alias_namesTYRO1
EphA4
Alias_symbol (synonym)Hek8
Other aliasHEK8
SEK
HGNC (Hugo) EPHA4
LocusID (NCBI) 2043
Atlas_Id 40464
Location 2q36.1  [Link to chromosome band 2q36]
Location_base_pair Starts at 222282747 and ends at 222438922 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EPHA4 (2q36.1) / COL4A3 (2q36.3)THOC3 (5q35.2) / EPHA4 (2q36.1)EPHA4 2q36.1 / COL4A3 2q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPHA4   3388
Cards
Entrez_Gene (NCBI)EPHA4  2043  EPH receptor A4
AliasesHEK8; SEK; TYRO1
GeneCards (Weizmann)EPHA4
Ensembl hg19 (Hinxton)ENSG00000116106 [Gene_View]  chr2:222282747-222438922 [Contig_View]  EPHA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116106 [Gene_View]  chr2:222282747-222438922 [Contig_View]  EPHA4 [Vega]
ICGC DataPortalENSG00000116106
TCGA cBioPortalEPHA4
AceView (NCBI)EPHA4
Genatlas (Paris)EPHA4
WikiGenes2043
SOURCE (Princeton)EPHA4
Genetics Home Reference (NIH)EPHA4
Genomic and cartography
GoldenPath hg19 (UCSC)EPHA4  -     chr2:222282747-222438922 -  2q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EPHA4  -     2q36.1   [Description]    (hg38-Dec_2013)
EnsemblEPHA4 - 2q36.1 [CytoView hg19]  EPHA4 - 2q36.1 [CytoView hg38]
Mapping of homologs : NCBIEPHA4 [Mapview hg19]  EPHA4 [Mapview hg38]
OMIM602188   
Gene and transcription
Genbank (Entrez)AA987900 AF075040 AK225181 AK290306 AK300772
RefSeq transcript (Entrez)NM_001304536 NM_001304537 NM_004438
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)EPHA4
Cluster EST : UnigeneHs.371218 [ NCBI ]
CGAP (NCI)Hs.371218
Alternative Splicing GalleryENSG00000116106
Gene ExpressionEPHA4 [ NCBI-GEO ]   EPHA4 [ EBI - ARRAY_EXPRESS ]   EPHA4 [ SEEK ]   EPHA4 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2043
GTEX Portal (Tissue expression)EPHA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54764   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54764  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54764
Splice isoforms : SwissVarP54764
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP54764
Domaine pattern : Prosite (Expaxy)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    Ephrin_rcpt_lig-bd_dom    FN3_dom    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07714    pfam07647   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
Conserved Domain (NCBI)EPHA4
DMDM Disease mutations2043
Blocks (Seattle)EPHA4
PDB (SRS)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
PDB (PDBSum)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
PDB (IMB)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
PDB (RSDB)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
Structural Biology KnowledgeBase2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
SCOP (Structural Classification of Proteins)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
CATH (Classification of proteins structures)2LW8    2WO1    2WO2    2WO3    3CKH    3GXU    4BK4    4BK5    4BKA    4BKF    4M4P    4M4R    4W4Z    4W50   
SuperfamilyP54764
Human Protein AtlasENSG00000116106
Peptide AtlasP54764
HPRD03719
IPIIPI00008318   IPI00916323   IPI00386267   IPI01010592   IPI00917056   IPI00916754   IPI00916447   IPI00916092   IPI00917445   IPI00916972   
Protein Interaction databases
DIP (DOE-UCLA)P54764
IntAct (EBI)P54764
FunCoupENSG00000116106
BioGRIDEPHA4
STRING (EMBL)EPHA4
ZODIACEPHA4
Ontologies - Pathways
QuickGOP54764
Ontology : AmiGOprotein kinase activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  protein binding  ATP binding  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell adhesion  adult walking behavior  motor neuron axon guidance  glial cell migration  cell surface  postsynaptic density  peptidyl-tyrosine phosphorylation  corticospinal tract morphogenesis  cell junction  filopodium  axon  dendrite  neuromuscular junction  early endosome membrane  PH domain binding  identical protein binding  regulation of GTPase activity  dendritic spine  perikaryon  positive regulation of JUN kinase activity  axon terminus  axonal growth cone  postsynaptic membrane  protein autophosphorylation  ephrin receptor binding  ephrin receptor signaling pathway  negative regulation of axon regeneration  regulation of astrocyte differentiation  regulation of axonogenesis  positive regulation of dendrite morphogenesis  regulation of dendritic spine morphogenesis  nephric duct morphogenesis  fasciculation of sensory neuron axon  fasciculation of motor neuron axon  DH domain binding  positive regulation of Rho guanyl-nucleotide exchange factor activity  
Ontology : EGO-EBIprotein kinase activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  protein binding  ATP binding  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell adhesion  adult walking behavior  motor neuron axon guidance  glial cell migration  cell surface  postsynaptic density  peptidyl-tyrosine phosphorylation  corticospinal tract morphogenesis  cell junction  filopodium  axon  dendrite  neuromuscular junction  early endosome membrane  PH domain binding  identical protein binding  regulation of GTPase activity  dendritic spine  perikaryon  positive regulation of JUN kinase activity  axon terminus  axonal growth cone  postsynaptic membrane  protein autophosphorylation  ephrin receptor binding  ephrin receptor signaling pathway  negative regulation of axon regeneration  regulation of astrocyte differentiation  regulation of axonogenesis  positive regulation of dendrite morphogenesis  regulation of dendritic spine morphogenesis  nephric duct morphogenesis  fasciculation of sensory neuron axon  fasciculation of motor neuron axon  DH domain binding  positive regulation of Rho guanyl-nucleotide exchange factor activity  
Pathways : BIOCARTAEph Kinases and ephrins support platelet aggregation [Genes]   
Pathways : KEGGAxon guidance   
NDEx NetworkEPHA4
Atlas of Cancer Signalling NetworkEPHA4
Wikipedia pathwaysEPHA4
Orthology - Evolution
OrthoDB2043
GeneTree (enSembl)ENSG00000116106
Phylogenetic Trees/Animal Genes : TreeFamEPHA4
HOVERGENP54764
HOGENOMP54764
Homologs : HomoloGeneEPHA4
Homology/Alignments : Family Browser (UCSC)EPHA4
Gene fusions - Rearrangements
Fusion : MitelmanEPHA4/COL4A3 [2q36.1/2q36.3]  
Fusion: TCGAEPHA4 2q36.1 COL4A3 2q36.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHA4
dbVarEPHA4
ClinVarEPHA4
1000_GenomesEPHA4 
Exome Variant ServerEPHA4
ExAC (Exome Aggregation Consortium)EPHA4 (select the gene name)
Genetic variants : HAPMAP2043
Genomic Variants (DGV)EPHA4 [DGVbeta]
DECIPHER (Syndromes)2:222282747-222438922  ENSG00000116106
CONAN: Copy Number AnalysisEPHA4 
Mutations
ICGC Data PortalEPHA4 
TCGA Data PortalEPHA4 
Broad Tumor PortalEPHA4
OASIS PortalEPHA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPHA4
intOGen PortalEPHA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHA4
DgiDB (Drug Gene Interaction Database)EPHA4
DoCM (Curated mutations)EPHA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHA4 (select a term)
intoGenEPHA4
Cancer3DEPHA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602188   
Orphanet106   
MedgenEPHA4
Genetic Testing Registry EPHA4
NextProtP54764 [Medical]
TSGene2043
GENETestsEPHA4
Huge Navigator EPHA4 [HugePedia]
snp3D : Map Gene to Disease2043
BioCentury BCIQEPHA4
ClinGenEPHA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2043
Chemical/Pharm GKB GenePA27820
Clinical trialEPHA4
Miscellaneous
canSAR (ICR)EPHA4 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHA4
EVEXEPHA4
GoPubMedEPHA4
iHOPEPHA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:00:11 CEST 2017

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